Article ; Online: Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19): relationship with mortality.
Internal and emergency medicine
2021 Volume 16, Issue 5, Page(s) 1231–1237
Abstract: Background: Patients with coronavirus disease 2019 (Covid-19) may experience venous thrombosis ... predicted morality.: Conclusions: Covid-19 patients experience an equipollent rate of venous and arterial ... and 75 (20%) died. Thrombotic events included 41 venous thromboembolism and 34 arterial thrombosis ...
| Abstract | Background: Patients with coronavirus disease 2019 (Covid-19) may experience venous thrombosis while data regarding arterial thrombosis are sparse. Methods: Prospective multicenter study in 5 hospitals including 373 patients with Covid-19-related pneumonia. Demographic data, laboratory findings including coagulation tests and comorbidities were reported. During the follow-up any arterial or venous thrombotic events and death were registered. Results: Among 373 patients, 75 (20%) had a thrombotic event and 75 (20%) died. Thrombotic events included 41 venous thromboembolism and 34 arterial thrombosis. Age, cardiovascular disease, intensive care unit treatment, white blood cells, D-dimer, albumin and troponin blood levels were associated with thrombotic events. In a multivariable regression logistic model, intensive care unit treatment (Odds Ratio [OR]: 6.0; 95% Confidence Interval [CI] 2.8-12.6; p < 0.001); coronary artery disease (OR: 2.4; 95% CI 1.4-5.0; p = 0.022); and albumin levels (OR: 0.49; 95% CI 0.28-0.87; p = 0.014) were associated with ischemic events. Age, sex, chronic obstructive pulmonary disease, diabetes, heart failure, coronary heart disease, intensive care unit treatment, in-hospital thrombotic events, D-dimer, C-reactive protein, troponin, and albumin levels were associated with mortality. A multivariable Cox regression analysis showed that in-hospital thrombotic events (hazard ratio [HR]: 2.72; 95% CI 1.59-4.65; p < 0.001), age (HR: 1.035; 95% CI 1.014-1.057; p = 0.001), and albumin (HR: 0.447; 95% CI 0.277-0.723; p = 0.001) predicted morality. Conclusions: Covid-19 patients experience an equipollent rate of venous and arterial thrombotic events, that are associated with poor survival. Early identification and appropriate treatment of Covid-19 patients at risk of thrombosis may improve prognosis. |
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| MeSH term(s) | Aged ; Aged, 80 and over ; C-Reactive Protein/analysis ; COVID-19/complications ; COVID-19/epidemiology ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/etiology ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Intensive Care Units/organization & administration ; Intensive Care Units/statistics & numerical data ; Kaplan-Meier Estimate ; Logistic Models ; Male ; Middle Aged ; Mortality/trends ; Odds Ratio ; Proportional Hazards Models ; Prospective Studies ; Thromboembolism/epidemiology ; Thromboembolism/etiology |
| Chemical Substances | Fibrin Fibrinogen Degradation Products ; fibrin fragment D ; C-Reactive Protein (9007-41-4) |
| Language | English |
| Publishing date | 2021-07-04 |
| Publishing country | Italy |
| Document type | Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2454173-4 |
| ISSN | 1970-9366 ; 1828-0447 |
| ISSN (online) | 1970-9366 |
| ISSN | 1828-0447 |
| DOI | 10.1007/s11739-020-02621-8 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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