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  1. Article ; Online: Short QT: when does it matter?

    Viswanathan, Mohan N / Page, Richard L

    Circulation

    2007  Volume 116, Issue 7, Page(s) 686–688

    MeSH term(s) Adult ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/mortality ; Electrocardiography ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Prognosis ; Syndrome
    Language English
    Publishing date 2007-08-14
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.107.720896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Short and long QT syndromes: does QT length really matter?

    Couderc, Jean-Philippe / Lopes, Coeli M

    Journal of electrocardiology

    2010  Volume 43, Issue 5, Page(s) 396–399

    Abstract: The short and long QT syndromes are inherited diseases associated with an increased risk for life ... ventricular fibrillation in individuals from a family with a history of sudden cardiac death exhibited very short QT ... interval and labeled the disease: short QT syndrome (SQTS). Over this decade, the SQTS was found to be ...

    Abstract The short and long QT syndromes are inherited diseases associated with an increased risk for life-threatening arrhythmias. The first case of long QT syndrome (LQTS) was reported more than 150 years ago, and the study of this disease led to crucial advancement of our understanding of channelopathies and associated ventricular arrhythmias. Ten years ago, Gussak et al. reported four cases of idiopathic ventricular fibrillation in individuals from a family with a history of sudden cardiac death exhibited very short QT interval and labeled the disease: short QT syndrome (SQTS). Over this decade, the SQTS was found to be a rare inherited syndrome with the potential to provide novel insights into the main mechanisms of cardiac arrhythmogenicity. In this review, we discuss these mechanisms and provocatively question the role of the QT interval duration as a surrogate marker of increased risk for arrhythmia in both the LQTS and the SQTS.
    MeSH term(s) Arrhythmias, Cardiac/complications ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/physiopathology ; Channelopathies/complications ; Channelopathies/genetics ; Channelopathies/physiopathology ; Death, Sudden, Cardiac/etiology ; Electrocardiography ; Humans ; Long QT Syndrome/complications ; Long QT Syndrome/genetics ; Long QT Syndrome/physiopathology ; Mutation ; Potassium Channels/genetics ; Risk Factors
    Chemical Substances Potassium Channels
    Language English
    Publishing date 2010-01-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 410286-1
    ISSN 1532-8430 ; 0022-0736
    ISSN (online) 1532-8430
    ISSN 0022-0736
    DOI 10.1016/j.jelectrocard.2010.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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