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  1. Book ; Online ; E-Book: The Renin Angiotensin System in Cardiovascular Disease

    Bhullar, Sukhwinder K. / Shah, Anureet K. / Dhalla, Naranjan S.

    (Advances in Biochemistry in Health and Disease, ; 24)

    2023  

    Abstract: ... of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical ... This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are ... of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book ...

    Author's details edited by Naranjan S. Dhalla, Sukhwinder K. Bhullar, Anureet K. Shah
    Series title Advances in Biochemistry in Health and Disease, ; 24
    Advances in biochemistry in health and disease
    Collection Advances in biochemistry in health and disease
    Abstract This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.
    Keywords Medicine/Research ; Biology/Research ; Cardiovascular system ; Physiology ; Cardiology ; Clinical biochemistry ; Biomedical Research ; Cardiovascular Physiology ; Medical Biochemistry
    Subject code 616.980214
    Language English
    Size 1 online resource (453 pages)
    Edition 1st ed. 2023.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-031-14952-1 ; 9783031149511 ; 978-3-031-14952-8 ; 3031149513
    DOI 10.1007/978-3-031-14952-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Prevention and management of cardiovascular and metabolic disease

    Katsagoni, Christina N. / Kokkinos, Peter / Sidossis, Labros S.

    physical activity, fitness and healthy aging

    2023  

    Author's details Christina N. Katsagoni, Peter Kokkinos, and Labros S. Sidossis
    Keywords Exercise ; Metabolic disorders in children
    Subject code 613.71
    Language English
    Size 1 online resource (413 pages)
    Publisher John Wiley & Sons Ltd
    Publishing place Chichester, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-119-83347-7 ; 1-119-83345-0 ; 9781119833444 ; 978-1-119-83347-5 ; 978-1-119-83345-1 ; 1119833442
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Nutrition and Cardiovascular Health

    Tappia, Paramjit S. / Blewett, Heather

    2020  

    Keywords Research & information: general ; Biology, life sciences ; Food & society ; magnesium deficiency ; arterial hypertension ; vascular tone ; arterial stiffness ; vascular remodeling ; insulin resistance ; magnesium supplementation ; dietary magnesium intake ; Zeb2 ; cardiac fibroblast ; activated myofibroblast ; cardiac fibrosis ; fibroblast contractility ; fish oil ; omega-3 fatty acids ; eicosapentaenoic acid (EPA) ; docosahexaenoic acid (DHA) ; cardiovascular disease ; irisin ; pediatric ; children ; nutrition ; diet ; body composition ; metabolic syndrome ; obesity, neonates ; Mediterranean diet ; inflammation ; nutrients ; polyphenols ; MUFA ; PUFA ; bioactive compounds ; phytosterols ; dietary pattern ; Aronia melanocarpa ; standardized extract ; dietary strategies ; supplementation ; cocaine ; cardiovascular health ; heart disease ; acute effects ; chronic effects ; marinobufagenin ; ouabain ; salt ; hypertension ; fibrosis ; Panax quinquefolius ; ginseng berry ; myocardial infarction ; phenolic compounds ; vascular aging ; vascular calcification ; arteriosclerosis ; Klotho ; chronic kidney disease (CKD), cancer ; diabetes ; heart failure ; micronutrients ; iron ; vitamins ; trace elements ; vitamin D ; seasonal variation ; lifestyle ; cytokines ; lipids ; mechanisms ; immunoregulatory ; eicosapentaenoic acid ; docosahexaenoic acid ; omega-3 polyunsaturated fatty acids ; coronary heart disease ; stretching ; TGF-β1 ; n/a
    Size 1 electronic resource (278 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044325
    ISBN 9783039288885 ; 3039288881
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: suPAR in cardiovascular disease.

    Montecillo, Jaya / Pirker, Thomas / Pemberton, Christopher / Chew-Harris, Janice

    Advances in clinical chemistry

    2024  Volume 121, Page(s) 89–131

    Abstract: ... It is postulated that suPAR may serve as an indicator of inflammatory activation and burden during CVD ... and migration. Studies have assessed the correlation between suPAR in cardiovascular disease (CVD ... mechanistic involvement in cardiovascular disease. In this review, we provide a background into suPAR and ...

    Abstract Soluble urokinase plasminogen activator receptor (suPAR), the soluble counterpart of urokinase plasminogen activator receptor, is found in the circulation at various levels. suPAR and its parent molecule, cell surface uPAR, exhibit similar structure and extracellular functional roles facilitating fibrinolysis, cellular adhesion, and migration. Studies have assessed the correlation between suPAR in cardiovascular disease (CVD). It is postulated that suPAR may serve as an indicator of inflammatory activation and burden during CVD progression. Increased suPAR independently predicts poorer outcomes in acute coronary syndromes, in heart failure, as well as in coronary artery disease and atherosclerosis. To guide translation into clinical utization, suPAR has been assessed in numerous CVD settings for improved risk discrimination independently or in association with established traditional risk factors. Whilst the involvement of suPAR has been explored in other diseases such as kidney diseases and cancer, there is only emerging evidence of suPAR's mechanistic involvement in cardiovascular disease. In this review, we provide a background into suPAR and its potential role as a biomarker in CVD.
    MeSH term(s) Humans ; Receptors, Urokinase Plasminogen Activator/blood ; Receptors, Urokinase Plasminogen Activator/metabolism ; Cardiovascular Diseases/metabolism ; Biomarkers/blood
    Chemical Substances Receptors, Urokinase Plasminogen Activator ; Biomarkers
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 210505-6
    ISSN 2162-9471 ; 0065-2423
    ISSN (online) 2162-9471
    ISSN 0065-2423
    DOI 10.1016/bs.acc.2024.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Canthaxanthin Mitigates Cardiovascular Senescence

    Wang, Zhefeng / Liu, Wenxing / Zhang, Min / Yan, Jianlong / Fei, Jia / Zhang, Keda / Dong, Shaohong

    Frontiers in bioscience (Landmark edition)

    2024  Volume 29, Issue 2, Page(s) 70

    Abstract: ... that more than 90% of cardiovascular disease occurs in the older people population, indicating that aging is ... one of the major risks involved in the development of cardiovascular disease. Therefore, retarding ... the development of cardiac aging is an important strategy to prevent aging-related cardiovascular ...

    Abstract Background: The number of older people in the world is increasing year by year; studies have shown that more than 90% of cardiovascular disease occurs in the older people population, indicating that aging is one of the major risks involved in the development of cardiovascular disease. Therefore, retarding the development of cardiac aging is an important strategy to prevent aging-related cardiovascular diseases.
    Methods: In the current study, we examined the anti-cardiovascular aging potential of canthaxanthin
    Results: We found that canthaxanthin obviously mitigated the cardiomyocyte senescence
    Conclusions: To sum up, the current work showed that canthaxanthin could obviously alleviate cardiac premature aging, indicating that canthaxanthin could be used as a biologically active molecule for the treatment of cardiac aging and fibrosis.
    MeSH term(s) Humans ; Animals ; Mice ; Aged ; Canthaxanthin/pharmacology ; Aging, Premature/pathology ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/pathology ; Aging ; Myocytes, Cardiac ; Fibrosis ; Cellular Senescence
    Chemical Substances Canthaxanthin (4C3C6403MU)
    Language English
    Publishing date 2024-02-29
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2902070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Nutraceutical Approaches to Cardiovascular and Metabolic Diseases: Evidence and Opportunities

    Magni, Paolo / Baragetti, Andrea / Poli, Andrea

    2023  

    Keywords Research & information: general ; Biology, life sciences ; Food & society ; Atherosclerotic Cardiovascular Diseases ; Gut Microbiota ; next generation sequencing ; oxysterols ; 24-OHC ; 25-OHC ; 27-OHC ; cholesterol metabolism ; probiotic ; cardiovascular risk ; hypercholesterolemia ; monacolin K ; nutraceutical ; very-low calorie ketogenic diet ; obesity ; insulin resistance ; diabetic retinopathy ; macular xanthophylls ; carotenoids ; macular pigment ; macular pigment optical density ; MPOD ; lutein ; zeaxanthin ; meso-zeaxanthin ; diabetes ; retinal neurodegeneration ; neuroprotection ; phytosterols ; plant sterols ; cholesterol ; cardiovascular disease ; supplements ; functional foods ; PREDIMED ; Mediterranean diet ; lipid profile ; polyphenols ; menopause ; body fat ; biomarkers ; tartaric acid ; nutraceuticals ; dyslipidaemia ; atherosclerosis ; tree nuts ; peanuts ; fatty acids ; prospective studies ; randomized clinical trials ; type-2 diabetes ; cancer ; hypertension ; cognitive function ; mortality ; body weight ; blood lipids ; inflammation ; dietary lipids ; immune-inflammation ; microbiota ; Cameroonian spice extracts ; SW 872 adipocytes ; triglyceride accumulation ; glucose uptake ; oxidative stress ; pro-inflammatory cytokines ; Prunus domestica L. ; chemical characterization ; digestive enzyme inhibition ; HMG-CoA reductase inhibition ; anti-inflammatory activity ; guidelines ; nutraceutical product ; metabolic disease ; type 2 diabetes mellitus ; n/a
    Language English
    Size 1 electronic resource (214 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030376406
    ISBN 9783036571317 ; 3036571310
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Book ; Online ; E-Book: Integrating lifestyle medicine in cardiovascular health and disease prevention

    Rippe, James M.

    (Lifestyle Medicine)

    2022  

    Abstract: ... on both the prevention and treatment of CVD through lifestyle measures such as regular physical activity, sound nutrition ... Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States ... Rippe, Integrating Lifestyle Medicine in Cardiovascular Health and Disease Prevention introduces ...

    Author's details James M. Rippe
    Series title Lifestyle Medicine
    Abstract "Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States and around the world. Major risk factors for CVD result from poor lifestyle habits and practices, but the area of lifestyle medicine has emerged to help clinicians and their patients understand the power of positive lifestyle habits and actions. Written by cardiologist and lifestyle medicine pioneer, Dr. James Rippe, Integrating Lifestyle Medicine in Cardiovascular Health and Disease Prevention introduces the principles of lifestyle medicine with the practice of cardiology to help lower the risk of heart disease and, if already present, assist in its treatment. This book provides evidence-based information on both the prevention and treatment of CVD through lifestyle measures such as regular physical activity, sound nutrition, weight management and avoidance of tobacco products. This information aids physicians and patients to better understand multiple linkages between poor habits and practices, employing them with associated behavioral techniques to lessen the likelihood of developing CVD"-- |c Provided by publisher.
    MeSH term(s) Preventive Medicine. ; Health Behavior.
    Keywords Cardiovascular system/Diseases/Prevention ; Cardiovascular system/Diseases/Treatment
    Subject code 616.105
    Language English
    Size 1 online resource (297 pages)
    Publisher CRC Press, Taylor & Francis Group
    Publishing place Boca Raton, FL
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-326814-5 ; 1-003-26814-5 ; 1-000-81382-7 ; 9781032213866 ; 978-1-00-326814-7 ; 978-1-003-26814-7 ; 978-1-000-81382-1 ; 1032213868
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Book ; Online: Nutrition, Exercise, and End-of-Life Discussion in the Cardiovascular Field

    Fukumoto, Yoshihiro

    2022  

    Keywords Medicine ; Pharmacology ; milk intake ; mortality ; stroke ; Bayesian survival anlysis ; time-to-event data ; JACC study ; unhealthy eating habits ; accumulation ; obesity ; central obesity ; general Japanese population ; atherosclerotic cardiovascular disease ; polyunsaturated fatty acids ; eicosapentaenoic acid ; docosahexaenoic acid ; arachidonic acid ; descriptive study ; heart failure ; vitamin D ; big data ; heart failure with preserved ejection fraction ; geriatric nutritional risk index ; behavioral modification stages ; nutrition counseling ; patient education ; acute coronary syndrome ; healthy behaviors ; diet ; legumes ; fish ; red/processed meat ; physical activity ; anxiety ; depression ; season ; calorie intake ; hospitalization ; malnutrition ; D-dimer ; intervention ; elderly ; cardiovascular mortality ; selenium ; coenzyme Q10 ; acylcarnitine ; brain natriuretic peptide ; cardiac function ; cardiomyopathy ; carnitine deficiency ; CPT2 ; end-stage kidney disease ; free fatty acid ; hemodialysis ; continuous glucose monitoring ; glucose fluctuation ; intracranial artery stenosis ; mean amplitude of glycemic excursions ; standard deviation ; palliative care ; end-of-life care discussion ; advance care planning ; food intake ; artificial nutrition ; onco-cardiology ; nutrition status ; cancer ; acute myocardial infarction ; plant-based dietary patterns ; grains ; nuts ; fruits ; vegetables ; cardiovascular disease ; n/a
    Language 0|e
    Size 1 electronic resource (194 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021610730
    ISBN 9783036538921 ; 3036538925
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Article: Cardiovascular Remodeling in Chronic Mineralocorticoid Excess.

    Bhattad, Pradnya Brijmohan / Roumia, Mazen

    Cureus

    2023  Volume 15, Issue 6, Page(s) e40753

    Abstract: ... aldosterone activity and an adrenal adenoma suggesting primary aldosteronism-induced diastolic heart failure ... The biochemical evaluation revealed elevated plasma aldosterone concentrations with low plasma renin activity ...

    Abstract Primary hyperaldosteronism typically leads to resistant hypertension, hypokalemia, and metabolic alkalosis. Excess aldosterone secretion by the adrenal glands may lead to heart failure with preserved ejection fraction. Potassium-sparing diuretics and aldosterone antagonists directed to lower excess aldosterone levels may help treat the associated heart failure and lead to control of blood pressure, resulting in improved outcomes. We report a case of a 55-year-old male with poorly controlled hypertension and newly symptomatic heart failure with preserved ejection fraction in the setting of excess aldosterone activity and an adrenal adenoma suggesting primary aldosteronism-induced diastolic heart failure. The biochemical evaluation revealed elevated plasma aldosterone concentrations with low plasma renin activity, diuretic-induced hypokalemia, and metabolic alkalosis. A progressively enlarging left adrenal adenoma was found on abdominal imaging along with resistant hypertension despite the use of multiple antihypertensive medications. Medical management targeted to lower excess aldosterone levels with the use of aldosterone antagonists helped us achieve better blood pressure control and resolution of symptoms of diastolic dysfunction. Treating the underlying pathology helped us improve overt heart failure and may suggest that goal-directed therapy towards the inciting factors may potentially lead to a path to reverse the heart failure symptoms clinically.
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.40753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cardiovascular Manifestations in Inflammatory Bowel Disease.

    Meda, Anish / Fredrick, Fremita / Rathod, Urvashi / Shah, Priyanshi / Jain, Rohit

    Current cardiology reviews

    2023  

    Abstract: ... to a hypercoagulable state caused by thrombocytosis and coagulation system activation. To reduce the risk of developing ... physical activity alongside management with appropriate medication, should be considered. This research paper ... of developing extraintestinal manifestations, including cardiovascular disease, thereby decreasing the quality ...

    Abstract Inflammatory bowel disease is a group of long-term systemic inflammatory disorders affecting the gastrointestinal tract, including Crohn's disease and ulcerative colitis, which may be associated with an increased risk of developing extraintestinal manifestations, including cardiovascular disease, thereby decreasing the quality of life. Pathophysiological changes associated with inflammatory bowel disease include alterations of the microbiome, endotoxemia, and changes to glucose and lipid metabolism. Inflammatory bowel disease patients have higher carotid intima-media thickness, lower flow-mediated dilatation, and increased carotid-femoral pulse wave velocity, which are markers of elevated cardiovascular risk. In addition, inflammatory bowel disease patients are at an increased risk for developing venous and arterial thrombotic events due to a hypercoagulable state caused by thrombocytosis and coagulation system activation. To reduce the risk of developing cardiovascular disease, lifestyle modifications, such as smoking cessation, dietary changes, and increased physical activity alongside management with appropriate medication, should be considered. This research paper examines how inflammatory bowel disease can influence the risk of cardiovascular complications and the involvement of drug therapy. Methods: PubMed was searched using keywords, such as inflammatory bowel disease, Crohn's disease, ulcerative colitis, cardiovascular disease, pericarditis, thromboembolism, and many more. Relevant literature up to March 2023 has been examined and summarized, which consisted of data from various clinical trials, meta-analyses, retrospective/prospective cohort studies, and current guidelines.
    Language English
    Publishing date 2023-11-24
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6557
    ISSN (online) 1875-6557
    DOI 10.2174/011573403X256094231031074753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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