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Article ; Online: Behaviors, symptoms, and outcomes of North American patients with autoimmune hepatitis during the COVID-19 pandemic.

Vuppalanchi, Vahin / Gelow, Kayla / Green, Kelsey / Vuppalanchi, Raj / Lammert, Craig

Journal of investigative medicine : the official publication of the American Federation for Clinical Research

2021  Volume 69, Issue 8, Page(s) 1426–1433

Abstract: ... of living through the SARS-CoV-2 pandemic on the extrahepatic symptoms and behaviors of patients with AIH ... The management of patients with autoimmune hepatitis (AIH) in the era of SARS-CoV-2 is challenging ... symptoms consistent with COVID-19 illness versus those who did not. Additionally, we explored the effect ...

Abstract The management of patients with autoimmune hepatitis (AIH) in the era of SARS-CoV-2 is challenging given minimal published clinical data. We used a large cohort of patients with AIH across the USA to investigate the differences in known risk factors for severe SARS-CoV-2 and AIH characteristics among patients who experienced symptoms consistent with COVID-19 illness versus those who did not. Additionally, we explored the effect of living through the SARS-CoV-2 pandemic on the extrahepatic symptoms and behaviors of patients with AIH. An invitation to complete a COVID-19-specific questionnaire was publicized in well-established social media cohorts of patients with AIH. Eligibility criteria were age ≥18 years, US residency, and an AIH diagnosis by a physician. A total of 420 individuals were eligible for the study. Symptoms consistent with COVID-19 were reported in 11% (n=48) with 3 patients requiring hospitalizations. Body mass index (BMI) >40 kg/m
MeSH term(s) Anxiety ; COVID-19/epidemiology ; Fatigue ; Hepatitis, Autoimmune/epidemiology ; Humans ; Immunosuppression Therapy ; Liver Cirrhosis ; Pandemics ; Pruritus ; United States/epidemiology
Language English
Publishing date 2021-07-27
Publishing country England
Document type Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID 1217870-6
ISSN 1708-8267 ; 0009-9279 ; 1081-5589
ISSN (online) 1708-8267
ISSN 0009-9279 ; 1081-5589
DOI 10.1136/jim-2021-001871
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