Article ; Online: T-ALL and thymocytes: a message of noncoding RNAs.
Journal of hematology & oncology
2017 Volume 10, Issue 1, Page(s) 66
Abstract: ... with microRNAs and later expanded towards long noncoding RNAs. This was also the case for T cell ... it became apparent that several of these oncogenes function via microRNAs and long noncoding RNAs ... In the last decade, the role for noncoding RNAs in disease was clearly established, starting ...
| Abstract | In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs. This was also the case for T cell acute lymphoblastic leukemia, which is a malignant blood disorder arising from oncogenic events during normal T cell development in the thymus. By studying the transcriptomic profile of protein-coding genes, several oncogenic events leading to T cell acute lymphoblastic leukemia (T-ALL) could be identified. In recent years, it became apparent that several of these oncogenes function via microRNAs and long noncoding RNAs. In this review, we give a detailed overview of the studies that describe the noncoding RNAome in T-ALL oncogenesis and normal T cell development. |
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| MeSH term(s) | Animals ; Carcinogenesis/genetics ; Humans ; Lymphopoiesis/genetics ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; RNA, Untranslated/analysis ; RNA, Untranslated/physiology ; Thymocytes |
| Chemical Substances | RNA, Untranslated |
| Language | English |
| Publishing date | 2017-03-07 |
| Publishing country | England |
| Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2429631-4 |
| ISSN | 1756-8722 ; 1756-8722 |
| ISSN (online) | 1756-8722 |
| ISSN | 1756-8722 |
| DOI | 10.1186/s13045-017-0432-0 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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