Artikel ; Online: 1918 pandemic influenza virus and Streptococcus pneumoniae co-infection results in activation of coagulation and widespread pulmonary thrombosis in mice and humans.
2015 Band 238, Heft 1, Seite(n) 85–97
Abstract: ... with the 1918 influenza virus, followed by Streptococcus pneumoniae (SP) 72 h later. Co-infected mice exhibited ... influenza virus and SP co-infection in mice and humans is extensive expression of tissue factor and activation ... To study bacterial co-infection following 1918 H1N1 influenza virus infection, mice were inoculated ...
| Abstract | To study bacterial co-infection following 1918 H1N1 influenza virus infection, mice were inoculated with the 1918 influenza virus, followed by Streptococcus pneumoniae (SP) 72 h later. Co-infected mice exhibited markedly more severe disease, shortened survival time and more severe lung pathology, including widespread thrombi. Transcriptional profiling revealed activation of coagulation only in co-infected mice, consistent with the extensive thrombogenesis observed. Immunohistochemistry showed extensive expression of tissue factor (F3) and prominent deposition of neutrophil elastase on endothelial and epithelial cells in co-infected mice. Lung sections of SP-positive 1918 autopsy cases showed extensive thrombi and prominent staining for F3 in alveolar macrophages, monocytes, neutrophils, endothelial and epithelial cells, in contrast to co-infection-positive 2009 pandemic H1N1 autopsy cases. This study reveals that a distinctive feature of 1918 influenza virus and SP co-infection in mice and humans is extensive expression of tissue factor and activation of the extrinsic coagulation pathway leading to widespread pulmonary thrombosis. |
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| Mesh-Begriff(e) | Animals ; Blood Coagulation ; Coinfection/complications ; Disease Models, Animal ; Female ; Humans ; Immunohistochemistry ; Influenza A Virus, H1N1 Subtype ; Influenza Pandemic, 1918-1919 ; Influenza, Human/complications ; Influenza, Human/microbiology ; Influenza, Human/pathology ; Mice ; Mice, Inbred BALB C ; Oligonucleotide Array Sequence Analysis ; Orthomyxoviridae Infections/complications ; Orthomyxoviridae Infections/microbiology ; Orthomyxoviridae Infections/pathology ; Pneumococcal Infections/complications ; Pneumococcal Infections/microbiology ; Pneumococcal Infections/pathology ; Pulmonary Embolism/microbiology ; Pulmonary Embolism/pathology ; Reverse Transcriptase Polymerase Chain Reaction ; Streptococcus pneumoniae | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2015-10-14 | |||||
| Erscheinungsland | England | |||||
| Dokumenttyp | Journal Article ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S. | |||||
| ZDB-ID | 3119-7 | |||||
| ISSN | 1096-9896 ; 0022-3417 | |||||
| ISSN (online) | 1096-9896 | |||||
| ISSN | 0022-3417 | |||||
| DOI | 10.1002/path.4638 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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