Artikel ; Online: Stationary phase lipophagy as a cellular mechanism to recycle sterols during quiescence.
2014 Band 10, Heft 11, Seite(n) 2075–2076
Abstract: ... microautophagy. Moreover, stationary phase lipophagy supplies quiescent yeast cells with sterols to sustain phase ... that the sterols boosted by LDs via stationary phase lipophagy promote the Lo microdomain maintenance that in turn ... microdomain underlying the network of vacuolar quasi-symmetrical micodomains. Stationary phase lipophagy uses ...
| Abstract | Delivery of cellular contents to yeast vacuoles/mammalian lysosomes via autophagy ensures long-term cell survival and extends life span. When cultured yeast cells are grown for a prolonged period of time to enter stationary phase, a nondividing state mimicking quiescence, vacuolar membrane proteins partition into either one of the vacuolar microdomains, liquid-ordered (Lo) or liquid-disordered (Ld). We show that during the transition to stationary phase, lipid droplets (LDs), organelles originated from the endoplasmic reticulum (ER), undergo lateral movement to reach the vacuolar surface and are confined within the specific Lo microdomain underlying the network of vacuolar quasi-symmetrical micodomains. Stationary phase lipophagy uses the autophagy machineries to modify the sterol-enriched Lo microdomain to engulf LDs and subsequently deposits the LD-containing vesicles inside the vacuole lumen, which is a pathway morphologically resembling microautophagy. Moreover, stationary phase lipophagy supplies quiescent yeast cells with sterols to sustain phase partitioning of lipids for vacuolar microdomain maintenance. A feed forward loop model was proposed to depict that the sterols boosted by LDs via stationary phase lipophagy promote the Lo microdomain maintenance that in turn stimulates lipophagy. |
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| Mesh-Begriff(e) | Autophagy ; Cell Survival ; Endoplasmic Reticulum/metabolism ; Lipid Metabolism ; Lipids/chemistry ; Lysosomes/metabolism ; Protein Structure, Tertiary ; Saccharomyces cerevisiae/metabolism ; Sterols/chemistry ; Vacuoles/metabolism | |||||
| Chemische Substanzen | Lipids ; Sterols | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2014 | |||||
| Erscheinungsland | United States | |||||
| Dokumenttyp | Journal Article | |||||
| ZDB-ID | 2454135-7 | |||||
| ISSN | 1554-8635 ; 1554-8627 | |||||
| ISSN (online) | 1554-8635 | |||||
| ISSN | 1554-8627 | |||||
| DOI | 10.4161/auto.36137 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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