Article: Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2.
2021 Volume 8, Page(s) 585358
Abstract: ... disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 ... and intra-host evolutions. ... The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus ...
| Abstract | The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions. |
|---|---|
| Language | English |
| Publishing date | 2021-02-15 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2775999-4 |
| ISSN | 2296-858X |
| ISSN | 2296-858X |
| DOI | 10.3389/fmed.2021.585358 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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