Article ; Online: Acute graft-versus-host disease after liver transplantation in a close contact with COVID-19: A case report.
2021 Volume 68, Page(s) 101435
Abstract: Acute graft-versus-host disease (aGVHD) is a rare complication after liver transplantation ... Fortunately, He was excluded from COVID-19 after nucleic acid and antibody tests. Though closely contact ... this is the first case report of a patient recovered from aGVHD as a close contact. ...
| Abstract | Acute graft-versus-host disease (aGVHD) is a rare complication after liver transplantation that characterized by high mortality. We presented a case of aGVHD after orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC). The patient suffered from fever, oral ulcer, rashes and diarrhea and had a co-infection with Cytomegalovirus (CMV). Short tandem repeat (STR) analysis for cluster of differentiation (CD3) cells and skin biopsy indicated aGVHD. His regimens included high dose of steroids, ruxolitinib, basiliximab, local liver radiotherapy and antibiotics prophylaxis, with the withdrawal of tacrolimus and MMF. Unfortunately, he developed an acute rejection followed by cytomegalovirus infection and lung infection. Soon afterwards he was sent to "isolation ward" due to high suspicion for clinical coronavirus disease 2019 (COVID-19). Fortunately, He was excluded from COVID-19 after nucleic acid and antibody tests. Though closely contact with other COVID-19 patients for a month, the patient was not affected with COVID-19 through his careful protective measures. Finally, the patient recovered after antiviral and antifungal treatment. To our knowledge, this is the first case report of a patient recovered from aGVHD as a close contact. |
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| MeSH term(s) | Acute Disease ; Antifungal Agents/administration & dosage ; Antiviral Agents/administration & dosage ; COVID-19/diagnosis ; COVID-19 Nucleic Acid Testing ; Carcinoma, Hepatocellular/therapy ; Cytomegalovirus ; Cytomegalovirus Infections/drug therapy ; Graft vs Host Disease/diagnosis ; Graft vs Host Disease/drug therapy ; Graft vs Host Disease/etiology ; Graft vs Host Disease/virology ; Humans ; Liver Neoplasms/therapy ; Liver Transplantation ; Male ; Middle Aged ; SARS-CoV-2 | |||||
| Chemical Substances | Antifungal Agents ; Antiviral Agents | |||||
| Language | English | |||||
| Publishing date | 2021-07-01 | |||||
| Publishing country | Netherlands | |||||
| Document type | Case Reports ; Journal Article | |||||
| ZDB-ID | 1160846-8 | |||||
| ISSN | 1878-5492 ; 0966-3274 | |||||
| ISSN (online) | 1878-5492 | |||||
| ISSN | 0966-3274 | |||||
| DOI | 10.1016/j.trim.2021.101435 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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