Article ; Online: SARS-CoV-2 restructures host chromatin architecture.
Nature microbiology
2023 Volume 8, Issue 4, Page(s) 679–694
Abstract: ... These findings show that SARS-CoV-2 acutely rewires host chromatin, facilitating future studies of the long-term ... we characterized the 3D genome and epigenome of human cells after SARS-CoV-2 infection, finding widespread host ... Some viruses restructure host chromatin, influencing gene expression, with implications for disease ...
| Abstract | Some viruses restructure host chromatin, influencing gene expression, with implications for disease outcome. Whether this occurs for SARS-CoV-2, the virus causing COVID-19, is largely unknown. Here we characterized the 3D genome and epigenome of human cells after SARS-CoV-2 infection, finding widespread host chromatin restructuring that features widespread compartment A weakening, A-B mixing, reduced intra-TAD contacts and decreased H3K27ac euchromatin modification levels. Such changes were not found following common-cold-virus HCoV-OC43 infection. Intriguingly, the cohesin complex was notably depleted from intra-TAD regions, indicating that SARS-CoV-2 disrupts cohesin loop extrusion. These altered 3D genome/epigenome structures correlated with transcriptional suppression of interferon response genes by the virus, while increased H3K4me3 was found in the promoters of pro-inflammatory genes highly induced during severe COVID-19. These findings show that SARS-CoV-2 acutely rewires host chromatin, facilitating future studies of the long-term epigenomic impacts of its infection. |
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| MeSH term(s) | Humans ; SARS-CoV-2/genetics ; Chromatin ; COVID-19 |
| Chemical Substances | Chromatin |
| Language | English |
| Publishing date | 2023-03-23 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. |
| ISSN | 2058-5276 |
| ISSN (online) | 2058-5276 |
| DOI | 10.1038/s41564-023-01344-8 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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