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  1. Article ; Online: AngiomiRs--key regulators of angiogenesis.

    Wang, Shusheng / Olson, Eric N

    Current opinion in genetics & development

    2009  Volume 19, Issue 3, Page(s) 205–211

    Abstract: ... especially angiogenesis. Mice with EC-specific deletion of Dicer, a key enzyme for generating miRNAs, display ... defective postnatal angiogenesis. Specific miRNAs (angiomiRs) have recently been shown to regulate ... The formation of new blood vessels through the process of angiogenesis is critical in vascular ...

    Abstract The formation of new blood vessels through the process of angiogenesis is critical in vascular development and homeostasis. Aberrant angiogenesis leads to a variety of diseases, such as ischemia and cancer. Recent studies have revealed important roles for miRNAs in regulating endothelial cell (EC) function, especially angiogenesis. Mice with EC-specific deletion of Dicer, a key enzyme for generating miRNAs, display defective postnatal angiogenesis. Specific miRNAs (angiomiRs) have recently been shown to regulate angiogenesis in vivo. miRNA-126, an EC-restricted miRNA, regulates vascular integrity and developmental angiogenesis. miR-378, miR-296, and the miR-17-92 cluster contribute to tumor angiogenesis. Manipulating angiomiRs in the settings of pathological vascularization represents a new therapeutic approach.
    MeSH term(s) Animals ; Blood Vessels/physiology ; Endothelial Cells/physiology ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Models, Biological ; Mutation ; Neovascularization, Physiologic/genetics ; Neovascularization, Physiologic/physiology ; Ribonuclease III/genetics ; Ribonuclease III/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances MicroRNAs ; Vascular Endothelial Growth Factor A ; Ribonuclease III (EC 3.1.26.3)
    Language English
    Publishing date 2009-05-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2009.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3240: Show issues Location:
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  2. Article ; Online: AngiomiRs: MicroRNAs driving angiogenesis in cancer (Review).

    Salinas-Vera, Yarely M / Marchat, Laurence A / Gallardo-Rincón, Dolores / Ruiz-García, Erika / Astudillo-De La Vega, Horacio / Echavarría-Zepeda, Raquel / López-Camarillo, César

    International journal of molecular medicine

    2018  Volume 43, Issue 2, Page(s) 657–670

    Abstract: Angiogenesis is an important hallmark of cancer serving a key role in tumor growth and metastasis ... been dubbed as angiomiRs, may target regulatory molecules driving angiogenesis, such as cytokines ... Therefore, tumor angiogenesis has become an attractive target for development of novel drug therapies. An increased ...

    Abstract Angiogenesis is an important hallmark of cancer serving a key role in tumor growth and metastasis. Therefore, tumor angiogenesis has become an attractive target for development of novel drug therapies. An increased amount of anti‑angiogenic compounds is currently in preclinical and clinical development for personalized therapies. However, resistance to current angiogenesis inhibitors is emerging, indicating that there is a need to identify novel anti‑angiogenic agents. In the last decade, the field of microRNA biology has exploded revealing unsuspected functions in tumor angiogenesis. These small non‑coding RNAs, which have been dubbed as angiomiRs, may target regulatory molecules driving angiogenesis, such as cytokines, metalloproteinases and growth factors, including vascular endothelial growth factor, platelet‑derived growth factor, fibroblast growth factor, epidermal growth factor, hypoxia inducible factor‑1, as well as mitogen‑activated protein kinase, phosphoinositide 3‑kinase and transforming growth factor signaling pathways. The present review discusses the current progress towards understanding the functions of miRNAs in tumor angiogenesis regulation in diverse types of human cancer. Furthermore, the potential clinical application of angiomiRs towards anti‑angiogenic tumor therapy was explored.
    MeSH term(s) Angiogenesis Inhibitors/genetics ; Angiogenesis Inhibitors/therapeutic use ; Animals ; Female ; Humans ; Mice ; MicroRNAs/genetics ; MicroRNAs/therapeutic use ; Molecular Targeted Therapy ; Neoplasms/blood supply ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/genetics ; Tumor Microenvironment/drug effects
    Chemical Substances Angiogenesis Inhibitors ; MicroRNAs
    Language English
    Publishing date 2018-11-27
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 1444428-8
    ISSN 1791-244X ; 1107-3756
    ISSN (online) 1791-244X
    ISSN 1107-3756
    DOI 10.3892/ijmm.2018.4003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Identification of Key microRNAs and Genes in Infantile Hemangiomas.

    Fu, Cong / Yang, Kun / Zou, Yuqing / Huo, Ran

    Frontiers in genetics

    2022  Volume 13, Page(s) 766561

    Abstract: ... Microribonucleic acids (miRNAs) have been demonstrated as critical regulators of gene expression in various diseases ... that DEGs were enriched in tumorigenesis- and angiogenesis-related pathways such as proteoglycans in cancer ... Infantile hemangiomas (IHs) are the most frequent vascular tumors that occur during infancy ...

    Abstract Infantile hemangiomas (IHs) are the most frequent vascular tumors that occur during infancy. Microribonucleic acids (miRNAs) have been demonstrated as critical regulators of gene expression in various diseases. However, the function of miRNAs in IH still remains largely unknown. In the present study, we performed a miRNA microarray analysis of IH and identified 68 differentially expressed miRNAs (DEMs). In addition, miRNA-gene networks and protein-protein interactions were constructed, and the hub miRNAs and genes of IH were screened out. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were used for biological analysis of DEMs and differentially expressed genes (DEGs). The pathway enrichment analysis of DEMs revealed several tumor-related pathways, including proteoglycans in cancer, signaling pathway regulating pluripotency of stem cells and TGF-beta signaling pathway. DEGs were mainly enriched in biological processes, including intracellular signal transduction, cell adhesion, and cell death. KEGG pathway analysis indicated that DEGs were enriched in tumorigenesis- and angiogenesis-related pathways such as proteoglycans in cancer, MAPK signaling pathway and Rap1 signaling pathway. Collectively, this study first established a comprehensive miRNA-gene network in IH, which should provide novel insights into IH pathogenesis and be beneficial to the understanding of neovascularization-related disorders.
    Language English
    Publishing date 2022-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.766561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: AngiomiR-126 expression and secretion from circulating CD34(+) and CD14(+) PBMCs: role for proangiogenic effects and alterations in type 2 diabetics.

    Mocharla, Pavani / Briand, Sylvie / Giannotti, Giovanna / Dörries, Carola / Jakob, Philipp / Paneni, Francesco / Lüscher, Thomas / Landmesser, Ulf

    Blood

    2012  Volume 121, Issue 1, Page(s) 226–236

    Abstract: ... subpopulations in this respect. AngiomiRs, microRNAs regulating angiogenesis, are key regulators of angiogenic ... Several peripheral blood mononuclear cell (PBMC)-derived cell populations can promote angiogenesis ... processes. The present study examines differential angiomiR expression/secretion from CD34(+)/CD14(+), CD34 ...

    Abstract Several peripheral blood mononuclear cell (PBMC)-derived cell populations can promote angiogenesis, and differences in CD34(+) or CD14(+) surface expression have been used to separate PBMC subpopulations in this respect. AngiomiRs, microRNAs regulating angiogenesis, are key regulators of angiogenic processes. The present study examines differential angiomiR expression/secretion from CD34(+)/CD14(+), CD34(+)/CD14(-), CD34(-)/CD14(+), and CD34(-)/CD14(-) PBMC subsets and their relevance for different proangiogenic properties. Notably, both circulating human CD34(+)/14(+) and CD34(+)/14(-) PBMC subsets and their supernatants exerted more potent proangiogenic effects compared with CD34(-) PBMC subsets. MiR-126 was identified as most differentially expressed angiomiR in CD34(+) compared with CD34(-) PBMC subsets, determined by miR-array and RT-PCR validation. Modulation of miR-126 by anti-miR-126 or miR-mimic-126 treatment resulted in significant loss or increase of proangiogenic effects of CD34(+) PBMCs. MiR-126 levels in supernatants of CD34(+) PBMC subsets were substantially higher compared with CD34(-) PBMC subsets. MiR-126 was secreted in microvesicles/exosomes, and inhibition of their release impaired CD34(+) PBMCs proangiogenic effects. Notably, high-glucose treatment or diabetes reduced miR-126 levels of CD34(+) PBMCs, associated with impaired proangiogenic properties that could be rescued by miR-mimic-126 treatment. The present findings provide a novel molecular mechanism underlying increased proangiogenic effects of CD34(+) PBMCs, that is, angiomiR-126 expression/secretion. Moreover, an alteration of angiomiR-126 expression in CD34(+) PBMCs in diabetes provides a novel pathway causing impaired proangiogenic effects.
    MeSH term(s) Animals ; Antigens, CD34/analysis ; Cells, Cultured/cytology ; Cells, Cultured/drug effects ; Culture Media, Conditioned/pharmacology ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Endothelial Cells/cytology ; Exosomes/metabolism ; Gene Expression Regulation/drug effects ; Glucose/pharmacology ; Hemangioblasts/cytology ; Hemangioblasts/metabolism ; Humans ; Leukocytes, Mononuclear/classification ; Leukocytes, Mononuclear/physiology ; Lipopolysaccharide Receptors/analysis ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Nude ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; MicroRNAs/metabolism ; MicroRNAs/physiology ; Middle Aged ; Neovascularization, Physiologic/genetics ; Neovascularization, Physiologic/physiology ; Specific Pathogen-Free Organisms ; Transfection
    Chemical Substances Antigens, CD34 ; Culture Media, Conditioned ; Lipopolysaccharide Receptors ; MIRN126 microRNA, human ; MicroRNAs ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2012-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2012-01-407106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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  5. Article ; Online: Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure: role for impaired in vivo neovascularization and cardiac repair capacity.

    Jakob, Philipp / Doerries, Carola / Briand, Sylvie / Mocharla, Pavani / Kränkel, Nicolle / Besler, Christian / Mueller, Maja / Manes, Costantina / Templin, Christian / Baltes, Christof / Rudin, Markus / Adams, Heiner / Wolfrum, Mathias / Noll, Georg / Ruschitzka, Frank / Lüscher, Thomas F / Landmesser, Ulf

    Circulation

    2012  Volume 126, Issue 25, Page(s) 2962–2975

    Abstract: Background: MicroRNAs are key regulators of angiogenic processes. Administration of angiogenic ... regulation of angiomiRs, microRNAs involved in angiogenesis, in angiogenic EOCs and circulating CD34(+) cells ... angiomiRs, expressed in angiogenic EOCs, revealed a pronounced loss of angiomiR-126 and -130a in angiogenic ...

    Abstract Background: MicroRNAs are key regulators of angiogenic processes. Administration of angiogenic early outgrowth cells (EOCs) or CD34(+) cells has been suggested to improve cardiac function after ischemic injury, in particular by promoting neovascularization. The present study therefore examines regulation of angiomiRs, microRNAs involved in angiogenesis, in angiogenic EOCs and circulating CD34(+) cells from patients with chronic heart failure (CHF) and the role for their cardiac repair capacity.
    Methods and results: Angiogenic EOCs and CD34(+) cells were isolated from patients with CHF caused by ischemic cardiomyopathy (n=45) and healthy subjects (n=35). In flow cytometry analyses, angiogenic EOCs were largely myeloid and positive for alternatively activated M2 macrophage markers. In vivo cardiac neovascularization and functional repair capacity were examined after transplantation into nude mice with myocardial infarction. Cardiac transplantation of angiogenic EOCs from healthy subjects markedly increased neovascularization and improved cardiac function, whereas no such effect was observed after transplantation of angiogenic EOCs from patients with CHF. Real-time polymerase chain reaction analysis of 14 candidate angiomiRs, expressed in angiogenic EOCs, revealed a pronounced loss of angiomiR-126 and -130a in angiogenic EOCs from patients with CHF that was also observed in circulating CD34(+) cells. Anti-miR-126 transfection markedly impaired the capacity of angiogenic EOCs from healthy subjects to improve cardiac function. miR-126 mimic transfection increased the capacity of angiogenic EOCs from patients with CHF to improve cardiac neovascularization and function.
    Conclusions: The present study reveals a loss of angiomiR-126 and -130a in angiogenic EOCs and circulating CD34(+) cells from patients with CHF. Reduced miR-126 expression was identified as a novel mechanism limiting their capacity to improve cardiac neovascularization and function that can be targeted by miR-126 mimic transfection.
    MeSH term(s) Animals ; Antigens, CD34/analysis ; Chronic Disease ; Female ; Heart/physiopathology ; Heart Failure/physiopathology ; Homeodomain Proteins/physiology ; Humans ; Intracellular Signaling Peptides and Proteins/physiology ; Male ; Membrane Proteins/physiology ; Mice ; MicroRNAs/analysis ; MicroRNAs/physiology ; Middle Aged ; Myocardial Ischemia/complications ; Myocardial Ischemia/physiopathology ; Neovascularization, Physiologic
    Chemical Substances Antigens, CD34 ; HOXA5 protein, human ; Homeodomain Proteins ; Intracellular Signaling Peptides and Proteins ; MIRN126 microRNA, human ; MIRN130 microRNA, human ; Membrane Proteins ; MicroRNAs ; SPRED1 protein, human
    Language English
    Publishing date 2012-12-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.112.093906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The pathogenesis of hemangiomas: a review.

    Bauland, Constantijn G / van Steensel, Maurice A M / Steijlen, Peter M / Rieu, Paul N M A / Spauwen, Paul H M

    Plastic and reconstructive surgery

    2006  Volume 117, Issue 2, Page(s) 29e–35e

    Abstract: ... of hemangiomas. 3. Give arguments for the angioblast theory for the origin of hemangiomas. 4. Identify key genes ... defects as the cause of the deranged angiogenesis of hemangiomas.: Conclusions: To date, no single ... Differentiate between hemangiomas and vascular malformations. 2. Describe arguments for the trophoblast origin ...

    Abstract Learning objectives: After reading this article, the participant should be able to: 1. Differentiate between hemangiomas and vascular malformations. 2. Describe arguments for the trophoblast origin of hemangiomas. 3. Give arguments for the angioblast theory for the origin of hemangiomas. 4. Identify key genes involved in the origin of hemangiomas.
    Background: Hemangiomas of infancy are common endothelial tumors. They differ from vascular malformations in their tissue architecture and biological properties. To date, there is no universally accepted theory that explains the pathogenesis and pathophysiology of hemangiomas.
    Methods: Theories from the medical literature from 1981 to 2004 were gathered, categorized, and reviewed.
    Results: Current research is mostly on the cellular and genetic levels. The most authoritative theories focus on angioblast origins, trophoblast origins, mutations in cytokine regulatory pathways, and field defects as the cause of the deranged angiogenesis of hemangiomas.
    Conclusions: To date, no single theory can easily explain all the characteristics of hemangiomas, such as predilection for the female sex, usual occurrence after birth, spontaneous involution, abnormal tissue architecture, and distribution within a developmental field. Hemangiomas are probably the final common expression of several pathophysiological mechanisms taking effect alone or in combination.
    MeSH term(s) Cytokines/metabolism ; Endothelial Cells/physiology ; Glucose Transporter Type 1/metabolism ; Hemangioma/diagnosis ; Hemangioma/embryology ; Hemangioma/etiology ; Hemangioma/physiopathology ; Humans ; Neovascularization, Pathologic ; Placental Hormones/metabolism ; Receptor, TIE-2/physiology
    Chemical Substances Cytokines ; Glucose Transporter Type 1 ; Placental Hormones ; Receptor, TIE-2 (EC 2.7.10.1)
    Language English
    Publishing date 2006-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/01.prs.0000197134.72984.cb
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 293: Show issues

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