Article ; Online: Broad-Spectrum Coronavirus Fusion Inhibitors to Combat COVID-19 and Other Emerging Coronavirus Diseases.
International journal of molecular sciences
2020 Volume 21, Issue 11
Abstract: ... Middle East respiratory syndrome (MERS), and the coronavirus disease 2019 (COVID-19 ... a conserved target site. This review will systematically describe potential broad-spectrum coronavirus fusion ... inhibitors, including antibodies, protease inhibitors, and peptide fusion inhibitors, along with a discussion ...
| Abstract | In the past 17 years, three novel coronaviruses have caused severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the coronavirus disease 2019 (COVID-19). As emerging infectious diseases, they were characterized by their novel pathogens and transmissibility without available clinical drugs or vaccines. This is especially true for the newly identified COVID-19 caused by SARS coronavirus 2 (SARS-CoV-2) for which, to date, no specific antiviral drugs or vaccines have been approved. Similar to SARS and MERS, the lag time in the development of therapeutics is likely to take months to years. These facts call for the development of broad-spectrum anti-coronavirus drugs targeting a conserved target site. This review will systematically describe potential broad-spectrum coronavirus fusion inhibitors, including antibodies, protease inhibitors, and peptide fusion inhibitors, along with a discussion of their advantages and disadvantages. |
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| MeSH term(s) | Animals ; Betacoronavirus/drug effects ; Betacoronavirus/physiology ; Coronavirus Infections/drug therapy ; Humans ; Protease Inhibitors/adverse effects ; Protease Inhibitors/pharmacology ; Protease Inhibitors/therapeutic use ; SARS-CoV-2 ; Viral Fusion Protein Inhibitors/adverse effects ; Viral Fusion Protein Inhibitors/pharmacology ; Viral Fusion Protein Inhibitors/therapeutic use ; Virus Internalization/drug effects |
| Chemical Substances | Protease Inhibitors ; Viral Fusion Protein Inhibitors |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-05-28 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms21113843 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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