Article ; Online: Ultrafast Surface Plasmon Resonance Imaging Sensor via the High-Precision Four-Parameter-Based Spectral Curve Readjusting Method.
2020 Volume 93, Issue 2, Page(s) 828–833
Abstract: ... implemented as the SPR excitation source. Especially, we developed a novel four-parameter-based spectral curve ... readjusting (4-PSCR) method for data processing, which offered us a faster and more accurate spectral data ... A variety of surface plasmon resonance (SPR) sensing devices have been extensively used ...
| Abstract | A variety of surface plasmon resonance (SPR) sensing devices have been extensively used in biochemical detection for their characteristics of label-free, highly sensitive, and faster detecting. Among them, the spectrum-based SPR sensing devices have offered us great advantages in high-throughput sensing due to their large dynamic range and the possibility of detection resolution similar to that offered by angle interrogation. This paper demonstrates a spectrum-based SPR imaging sensing system with fast wavelength scanning capability achieved by an acousto-optic tunable filter (AOTF) and a low-cost and speckle-free halogen lamp implemented as the SPR excitation source. Especially, we developed a novel four-parameter-based spectral curve readjusting (4-PSCR) method for data processing, which offered us a faster and more accurate spectral data curve fitting process than the traditional polynomial fitting method. With the configuration, we have also conducted an SPR high-throughput detection of the novel coronavirus (COVID-19) spike protein, proving its application possibility in the screening of COVID-19 with high accuracy. We believe that the higher sensitivity and accuracy of the system have made it readily used in biochemical imaging and detecting applications. |
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| MeSH term(s) | Algorithms ; COVID-19/diagnosis ; COVID-19/virology ; Humans ; Limit of Detection ; Optics and Photonics ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/analysis ; Spike Glycoprotein, Coronavirus/metabolism ; Surface Plasmon Resonance/instrumentation ; Surface Plasmon Resonance/methods ; Temperature | |||||
| Chemical Substances | Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 | |||||
| Language | English | |||||
| Publishing date | 2020-12-15 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 1508-8 | |||||
| ISSN | 1520-6882 ; 0003-2700 | |||||
| ISSN (online) | 1520-6882 | |||||
| ISSN | 0003-2700 | |||||
| DOI | 10.1021/acs.analchem.0c03347 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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