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  1. Book: Covid-19 molecular testing and clinical correlates

    Kanjilal, Sanjat

    (Clinics in laboratory medicine ; volume 42, number 2 (June 2022))

    2022  

    Author's details editors Sanjat Kanjilal, Yi-Wei Tang
    Series title Clinics in laboratory medicine ; volume 42, number 2 (June 2022)
    Collection
    Language English
    Size xv Seiten, Seite 130-307, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT021430235
    ISBN 978-0-323-84952-4 ; 0-323-84952-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 1695 -42,2- not available for loan Lesesaal EG

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  2. Book ; Online ; E-Book: Point-of-care testing of COVID-19

    Gangula, Abilash

    current status, clinical impact, and future therapeutic perspectives

    (SpringerBriefs in Applied Sciences and Technology)

    2022  

    Author's details Abilash Gangula, [and five others]
    Series title SpringerBriefs in Applied Sciences and Technology
    Keywords COVID-19 (Disease)
    Subject code 929.605
    Language English
    Size 1 online resource (79 pages)
    Publisher Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-19-4957-3 ; 9789811949562 ; 978-981-19-4957-9 ; 9811949565
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Clinical testing for COVID-19.

    Ward, Stephanie / Lindsley, Andrew / Courter, Josh / Assa'ad, Amal

    The Journal of allergy and clinical immunology

    2020  Volume 146, Issue 1, Page(s) 23–34

    Abstract: ... clinical and commercial laboratories to develop tests to detect the presence of the virus ... turnaround time. As the illnesses turned into a pandemic, testing became more crucial. The test supply became ... tests and discuss the basis for new serologic tests. We discuss the testing guidance for prioritization ...

    Abstract As the novel coronavirus severe acute respiratory syndrome coronavirus 2 caused coronavirus disease 2019 cases in the United States, the initial test was developed and performed at the Centers for Disease Control and Prevention. As the number of cases increased, the demand for tests multiplied, leading the Centers for Disease Control and Prevention to use the Emergency Utilization Authorization to allow clinical and commercial laboratories to develop tests to detect the presence of the virus. Many nucleic acid tests based on RT-PCR were developed, each with different techniques, specifications, and turnaround time. As the illnesses turned into a pandemic, testing became more crucial. The test supply became inadequate to meet the need and so it had to be prioritized according to guidance. For surveillance, the need for serologic tests emerged. Here, we review the timeline of test development, the turnaround times, and the various approved tests, and compare them as regards the genes they detect. We concentrate on the point-of-care tests and discuss the basis for new serologic tests. We discuss the testing guidance for prioritization and their application in a hospital setting.
    MeSH term(s) Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Point-of-Care Testing ; Real-Time Polymerase Chain Reaction/methods ; SARS-CoV-2 ; Serologic Tests/methods ; Viral Proteins/analysis
    Chemical Substances Viral Proteins
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2020.05.012
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  4. Article ; Online: Testing an Intervention to Improve Health Care Worker Well-Being During the COVID-19 Pandemic: A Cluster Randomized Clinical Trial.

    Meredith, Lisa S / Ahluwalia, Sangeeta / Chen, Peggy G / Dong, Lu / Farmer, Carrie M / Bouskill, Kathryn E / Dalton, Sarah / Qureshi, Nabeel / Blagg, Tara / Timmins, George / Schulson, Lucy B / Huilgol, Shreya S / Han, Bing / Williamson, Stephanie / Watson, Patricia / Schnurr, Paula P / Martineau, Monique / Davis, Katie / Cassells, Andrea /
    Tobin, Jonathan N / Gidengil, Courtney

    JAMA network open

    2024  Volume 7, Issue 4, Page(s) e244192

    Abstract: ... the effect of the COVID-19 pandemic on the well-being of health care workers (HCWs).: Objective ... to support HCWs' well-being at hospitals and federally qualified health centers (FQHCs) during the COVID-19 ... in the US. Participating sites were matched as pairs by type, size, and COVID-19 burden and then randomized ...

    Abstract Importance: Stress First Aid is an evidence-informed peer-to-peer support intervention to mitigate the effect of the COVID-19 pandemic on the well-being of health care workers (HCWs).
    Objective: To evaluate the effectiveness of a tailored peer-to-peer support intervention compared with usual care to support HCWs' well-being at hospitals and federally qualified health centers (FQHCs) during the COVID-19 pandemic.
    Design, setting, and participants: This cluster randomized clinical trial comprised 3 cohorts of HCWs who were enrolled from March 2021 through July 2022 at 28 hospitals and FQHCs in the US. Participating sites were matched as pairs by type, size, and COVID-19 burden and then randomized to the intervention arm or usual care arm (any programs already in place to support HCW well-being). The HCWs were surveyed before and after peer-to-peer support intervention implementation. Intention-to-treat (ITT) analysis was used to evaluate the intervention's effect on outcomes, including general psychological distress and posttraumatic stress disorder (PTSD).
    Intervention: The peer-to-peer support intervention was delivered to HCWs by site champions who received training and subsequently trained the HCWs at their site. Recipients of the intervention were taught to respond to their own and their peers' stress reactions.
    Main outcomes and measures: Primary outcomes were general psychological distress and PTSD. General psychological distress was measured with the Kessler 6 instrument, and PTSD was measured with the PTSD Checklist.
    Results: A total of 28 hospitals and FQHCs with 2077 HCWs participated. Both preintervention and postintervention surveys were completed by 2077 HCWs, for an overall response rate of 28% (41% at FQHCs and 26% at hospitals). A total of 862 individuals (696 females [80.7%]) were from sites that were randomly assigned to the intervention arm; the baseline mean (SD) psychological distress score was 5.86 (5.70) and the baseline mean (SD) PTSD score was 16.11 (16.07). A total of 1215 individuals (947 females [78.2%]) were from sites assigned to the usual care arm; the baseline mean (SD) psychological distress score was 5.98 (5.62) and the baseline mean (SD) PTSD score was 16.40 (16.43). Adherence to the intervention was 70% for FQHCs and 32% for hospitals. The ITT analyses revealed no overall treatment effect for psychological distress score (0.238 [95% CI, -0.310 to 0.785] points) or PTSD symptom score (0.189 [95% CI, -1.068 to 1.446] points). Post hoc analyses examined the heterogeneity of treatment effect by age group with consistent age effects observed across primary outcomes (psychological distress and PTSD). Among HCWs in FQHCs, there were significant and clinically meaningful treatment effects for HCWs 30 years or younger: a more than 4-point reduction for psychological distress (-4.552 [95% CI, -8.067 to -1.037]) and a nearly 7-point reduction for PTSD symptom scores (-6.771 [95% CI, -13.224 to -0.318]).
    Conclusions and relevance: This trial found that this peer-to-peer support intervention did not improve well-being outcomes for HCWs overall but had a protective effect against general psychological distress and PTSD in HCWs aged 30 years or younger in FQHCs, which had higher intervention adherence. Incorporating this peer-to-peer support intervention into medical training, with ongoing support over time, may yield beneficial results in both standard care and during public health crises.
    Trial registration: ClinicalTrials.gov Identifier: NCT04723576.
    MeSH term(s) Humans ; COVID-19/psychology ; COVID-19/epidemiology ; Female ; Male ; Adult ; Health Personnel/psychology ; SARS-CoV-2 ; Pandemics ; Stress Disorders, Post-Traumatic/therapy ; Stress Disorders, Post-Traumatic/psychology ; Middle Aged ; Peer Group ; Psychological Distress ; United States ; Stress, Psychological/therapy
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2024.4192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Proceedings of the Clinical Microbiology Open 2022-assessing clinical laboratory and industry responses to COVID-19 pandemic testing capacity challenges (part 1).

    Peaper, David R / Doern, Christopher D / Sharp, Susan

    Journal of clinical microbiology

    2024  Volume 62, Issue 3, Page(s) e0094123

    Abstract: As the COVID-19 pandemic winds down, clinical and public health laboratories, along with industry ... and better prepare for the next pandemic, the Clinical Microbiology Open (CMO) assembled key ... stakeholders including directors of clinical laboratories, industry partners, and state and federal agencies ...

    Abstract As the COVID-19 pandemic winds down, clinical and public health laboratories, along with industry partners, reflect on the successes and failures of the pandemic response. To capture the lessons learned and better prepare for the next pandemic, the Clinical Microbiology Open (CMO) assembled key stakeholders including directors of clinical laboratories, industry partners, and state and federal agencies such as the Centers for Disease Control and Prevention and the Food and Drug Administration. Participants were asked to provide their perspectives on the initial pandemic response, supply chain constraints especially during surges, staffing challenges, test triage and communication strategies, clinical informatics needs, laboratory financial impacts of SARS-CoV-2 testing, and the emergency use authorization process. This manuscript summarizes the diagnostic laboratory and industry perspectives on these issues that were presented and discussed at CMO and proposes some steps that could be taken to improve future pandemic responses.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19 Testing ; Laboratories, Clinical ; SARS-CoV-2 ; Pandemics/prevention & control
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.00941-23
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  6. Article ; Online: D-dimer Testing in COVID-19: From Basics to Clinical Application.

    Moiz, Bushra

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2022  Volume 32, Issue 1, Page(s) 2–3

    Abstract: Null. ...

    Abstract Null.
    MeSH term(s) Biomarkers ; COVID-19/diagnosis ; COVID-19 Testing ; Fibrin Fibrinogen Degradation Products/analysis ; Humans
    Chemical Substances Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D
    Language English
    Publishing date 2022-01-24
    Publishing country Pakistan
    Document type Editorial
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2022.01.2
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  7. Article ; Online: Clinical testing for COVID-19

    Ward, Stephanie / Lindsley, Andrew / Courter, Josh / Assa’ad, Amal

    Journal of Allergy and Clinical Immunology

    2020  Volume 146, Issue 1, Page(s) 23–34

    Keywords Immunology ; Immunology and Allergy ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 121011-7
    ISSN 1085-8725 ; 1097-6825 ; 0091-6749
    ISSN (online) 1085-8725 ; 1097-6825
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2020.05.012
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Clinical testing for COVID-19

    Ward, Stephanie / Lindsley, Andrew / Courter, Josh / Assa039, / ad, Amal

    J Allergy Clin Immunol

    Abstract: ... clinical and commercial laboratories to develop tests to detect the presence of the virus ... turnaround time. As the illnesses turned into a pandemic, testing became more crucial. The test supply became ... tests and discuss the basis for new serologic tests. We discuss the testing guidance for prioritization ...

    Abstract As the novel coronavirus severe acute respiratory syndrome coronavirus 2 caused coronavirus disease 2019 cases in the United States, the initial test was developed and performed at the Centers for Disease Control and Prevention. As the number of cases increased, the demand for tests multiplied, leading the Centers for Disease Control and Prevention to use the Emergency Utilization Authorization to allow clinical and commercial laboratories to develop tests to detect the presence of the virus. Many nucleic acid tests based on RT-PCR were developed, each with different techniques, specifications, and turnaround time. As the illnesses turned into a pandemic, testing became more crucial. The test supply became inadequate to meet the need and so it had to be prioritized according to guidance. For surveillance, the need for serologic tests emerged. Here, we review the timeline of test development, the turnaround times, and the various approved tests, and compare them as regards the genes they detect. We concentrate on the point-of-care tests and discuss the basis for new serologic tests. We discuss the testing guidance for prioritization and their application in a hospital setting.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #324603
    Database COVID19

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  9. Article ; Online: The effect of COVID-19 on referral patterns for clinical electrophysiological testing.

    Grinton, Michael E / Yan, Peng / Wright, Tom

    Documenta ophthalmologica. Advances in ophthalmology

    2022  Volume 146, Issue 1, Page(s) 3–6

    Abstract: Purpose: To provide an overview of the effect that the COVID-19 pandemic has had on visual ... to the COVID-19 pandemic (1 September 2019 to 30 November 2019) were compared to a 3-month period after ... the start of the COVID-19 pandemic (1 September 2021 to 30 November 2021).: Results: A total of 502 ...

    Abstract Purpose: To provide an overview of the effect that the COVID-19 pandemic has had on visual electrophysiology referral patterns and the subsequent effect this may have on patients.
    Methods: All electrodiagnostic tests performed at Kensington Vision and Research Centre, Toronto Canada, in a 3-month period prior to the COVID-19 pandemic (1 September 2019 to 30 November 2019) were compared to a 3-month period after the start of the COVID-19 pandemic (1 September 2021 to 30 November 2021).
    Results: A total of 502 patients had electrodiagnostic testing carried out in the designated time periods: 292 in the time period prior to the COVID-19 pandemic and 210 patients after. There was a significant change in the reason for referral in patients pre-COVID compared to post-COVID (p = 0.004). There was a 43% reduction in referrals for drug monitoring, 25% reduction for hereditary pathology and a 27% increase in acquired pathology after the start of the COVID-19 pandemic compared to before.
    Conclusions: There was a substantial decrease in the total number of patients referred after the start of the COVID-19 pandemic compared to pre-COVID with inherited retinal pathology and drug monitoring patients being 2 populations most affected by the disruption to healthcare services.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; Electroretinography ; Referral and Consultation ; Retina
    Language English
    Publishing date 2022-12-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 212594-8
    ISSN 1573-2622 ; 0012-4486
    ISSN (online) 1573-2622
    ISSN 0012-4486
    DOI 10.1007/s10633-022-09908-5
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  10. Article ; Online: D-dimer testing in clinical practice in the era of COVID-19.

    Auditeau, Claire / Khider, Lina / Planquette, Benjamin / Sanchez, Olivier / Smadja, David M / Gendron, Nicolas

    Research and practice in thrombosis and haemostasis

    2022  Volume 6, Issue 4, Page(s) e12730

    Abstract: ... with COVID-19. This report focuses on validated applications of D-dimer testing in patients with and ... hence an indirect biomarker of the hemostatic system activation. Early in the coronavirus disease 2019 (COVID-19 ... without COVID-19. ...

    Abstract D-dimer is a fragment of crosslinked fibrin resulting from plasmin cleavage of fibrin clots and hence an indirect biomarker of the hemostatic system activation. Early in the coronavirus disease 2019 (COVID-19) pandemic, several studies described coagulation disorders in affected patients, including high D-dimer levels. Consequently, D-dimer has been widely used in not-yet-approved indications. Ruling out pulmonary embolism and deep vein thrombosis in patients with low or intermediate clinical suspicion is the main application of D-dimer. D-dimer is also used to estimate the risk of venous thromboembolism recurrence and is included in the ISTH algorithm for the diagnosis of disseminated intravascular coagulation. Finally, numerous studies identified high D-dimer levels as a biomarker of poor prognosis in hospitalized patients with COVID-19. This report focuses on validated applications of D-dimer testing in patients with and without COVID-19.
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1002/rth2.12730
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