Article ; Online: Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid.
Mayo Clinic proceedings. Innovations, quality & outcomes
2019 Volume 3, Issue 4, Page(s) 448–460
Abstract: ... health associate with urinary magnesium and calcium excretion. ... strong evidence of an association with urinary magnesium excretion. The strongest signal in this region ... and uric acid excretion; total urine volume).: Results: One region on chromosome 9q21.13 showed ...
| Abstract | Objectives: The urinary excretion of organic and inorganic substances and their concentrations have attracted extensive attention for their role in the pathogenesis of urinary stone disease. The urinary excretion of specific factors associates with sex and age and seems to have a hereditary component, but the precise genomic determinants remain ill-defined. Methods: Genome-wide association studies previously conducted in 3 cohorts (Genetic Epidemiology Network of Arteriopathy study, January 1, 2006, through December 31, 2012; the combined Nurses' Health Study (NHS), NHS II, and Health Professionals Follow-up Study, January 1, 1994, through December 31, 2003; and the Prevention of Renal and Vascular End-stage Disease study, January 1, 1997, through December 31, 1998) were combined into meta-analyses to evaluate genetic associations with available urinary phenotypes relevant to stone pathogenesis (calcium, magnesium, and uric acid excretion; total urine volume). Results: One region on chromosome 9q21.13 showed strong evidence of an association with urinary magnesium excretion. The strongest signal in this region was near Conclusion: Common variants near genes important for magnesium metabolism and bone health associate with urinary magnesium and calcium excretion. |
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| Language | English |
| Publishing date | 2019-11-22 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ISSN | 2542-4548 |
| ISSN (online) | 2542-4548 |
| DOI | 10.1016/j.mayocpiqo.2019.08.007 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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