Article: Inflammatory response and antigen localization following immunization with influenza virus ISCOMs.
1989 Volume 13, Issue 6, Page(s) 641–649
Abstract: ... immunization with influenza virus glycoproteins presented in two physically defined forms--micelles and ISCOMS ... The inflammatory response, antigen retention, and antigen localization was studied in mice after ... At all times tested, animals given ISCOMs had significantly more radioactive antigen in their spleens ...
| Abstract | The inflammatory response, antigen retention, and antigen localization was studied in mice after immunization with influenza virus glycoproteins presented in two physically defined forms--micelles and ISCOMS (immunostimulating complexes). Two hours after intraperitoneal injection, the proportion of polymorphonuclear leukocytes (PMNs) in peritoneal lavage cells increased from less than 1% to 82% in ISCOM-treated mice and from less than 1% to 41% of the total cell count in micelle-treated mice. For both treatment groups, the proportion of PMNs returned to around zero 24 h postimmunization. Total recovery of radioactive antigen was significantly greater (P less than 0.05) in ISCOM-treated than in micelle-treated mice at one, two, and eight days postinjection. At all times tested, animals given ISCOMs had significantly more radioactive antigen in their spleens than animals given micelles. By electron microscopy ISCOMs were found to attach externally to the plasma membrane or within phagosomes of macrophages in close association with the membranes. |
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| MeSH term(s) | Animals ; Antigen-Antibody Complex ; Antigens/analysis ; Ascitic Fluid/immunology ; Female ; Glycoproteins/analysis ; Glycoproteins/immunology ; Immunization ; Inflammation/immunology ; Inflammation/pathology ; Mice ; Mice, Inbred Strains ; Micelles ; Microscopy, Electron ; Orthomyxoviridae/immunology ; Peritoneal Cavity/pathology | |||||
| Chemical Substances | Antigen-Antibody Complex ; Antigens ; Glycoproteins ; Micelles | |||||
| Language | English | |||||
| Publishing date | 1989-12 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 434408-x | |||||
| ISSN | 0360-3997 | |||||
| ISSN | 0360-3997 | |||||
| DOI | 10.1007/bf00914308 | |||||
| Shelf mark |
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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