Article: Deciphering the pathway from the TCR to NF-kappaB.
Cell death and differentiation
2006 Volume 13, Issue 5, Page(s) 826–833
Abstract: ... kappaB (NF-kappaB). Controlled activation of NF-kappaB is essential for the immune and inflammatory ... complex is the central integrator of most stimuli leading to NF-kappaB activation, but a detailed ... mechanisms involved in the cascade leading to NF-kappaB activation following engagement of the T-cell ...
| Abstract | A major regulator of lymphocyte survival and activation is the transcription factor nuclear factor-kappaB (NF-kappaB). Controlled activation of NF-kappaB is essential for the immune and inflammatory response as well as for cell proliferation and protection against apoptosis. The NEMO/IkappaB kinase (IKK) complex is the central integrator of most stimuli leading to NF-kappaB activation, but a detailed knowledge of the upstream events is available only for a limited number of stimuli. In particular, although most players have probably been identified, relatively little is known about the detailed molecular mechanisms involved in the cascade leading to NF-kappaB activation following engagement of the T-cell receptor by a foreign antigen. In this review, we discuss recent insights into this specific signal transduction cascade, and the way it is controlled both spatially and temporally. |
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| MeSH term(s) | Adaptor Proteins, Signal Transducing/metabolism ; Apoptosis Regulatory Proteins/metabolism ; Gene Expression Regulation ; Humans ; I-kappa B Kinase/metabolism ; Lymphoma, B-Cell, Marginal Zone/metabolism ; Models, Biological ; NF-kappa B/metabolism ; Protein Kinase C/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction | ||||||||||
| Chemical Substances | Adaptor Proteins, Signal Transducing ; Apoptosis Regulatory Proteins ; NF-kappa B ; Receptors, Antigen, T-Cell ; I-kappa B Kinase (EC 2.7.11.10) ; Protein Kinase C (EC 2.7.11.13) | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2006-05 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Journal Article ; Review | ||||||||||
| ZDB-ID | 1225672-9 | ||||||||||
| ISSN | 1350-9047 | ||||||||||
| ISSN | 1350-9047 | ||||||||||
| DOI | 10.1038/sj.cdd.4401856 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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