Article ; Online: Prognostic performance of troponin in COVID-19: A diagnostic meta-analysis and meta-regression.
2021 Volume 105, Page(s) 312–318
Abstract: ... COVID-19) and is associated with increased risk of mortality. Elevated troponin may signify myocardial ... meta-analysis. The mortality rate was 23% (20-26%). Elevated troponin was observed in 31% (23-38%) of patients ... in patients with COVID-19 with 55% sensitivity and 80% specificity. ...
| Abstract | Background: Cardiac injury is frequently encountered in patients with coronavirus disease 2019 (COVID-19) and is associated with increased risk of mortality. Elevated troponin may signify myocardial damage and is predictive of mortality. This study aimed to assess the prognostic value of troponin above the 99th percentile upper reference limit (URL) for mortality, and factors affecting the relationship. Methods: A comprehensive literature search of PubMed (MEDLINE), Scopus and Embase was undertaken, from inception of the databases until 16 December 2020. The key exposure was elevated serum troponin, defined as troponin (of any type) above the 99th percentile URL. The outcome was mortality due to any cause. Results: In total, 12,262 patients from 13 studies were included in this systematic review and meta-analysis. The mortality rate was 23% (20-26%). Elevated troponin was observed in 31% (23-38%) of patients. Elevated troponin was associated with increased mortality [odds ratio (OR) 4.75, 95% confidence interval (CI) 4.07-5.53; P < 0.001; I Conclusion: Elevated troponin was associated with mortality in patients with COVID-19 with 55% sensitivity and 80% specificity. |
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| MeSH term(s) | Biomarkers/blood ; COVID-19/mortality ; Female ; Humans ; Male ; Myocardium/chemistry ; Prognosis ; Reference Values ; SARS-CoV-2 ; Sensitivity and Specificity ; Troponin/blood | |||||
| Chemical Substances | Biomarkers ; Troponin | |||||
| Language | English | |||||
| Publishing date | 2021-03-02 | |||||
| Publishing country | Canada | |||||
| Document type | Journal Article ; Meta-Analysis ; Systematic Review | |||||
| ZDB-ID | 1331197-9 | |||||
| ISSN | 1878-3511 ; 1201-9712 | |||||
| ISSN (online) | 1878-3511 | |||||
| ISSN | 1201-9712 | |||||
| DOI | 10.1016/j.ijid.2021.02.113 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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