Article: Molecular processes that handle -- and mishandle -- dietary lipids.
The Journal of clinical investigation
2008 Volume 118, Issue 10, Page(s) 3247–3259
Abstract: Overconsumption of lipid-rich diets, in conjunction with physical inactivity, disables and kills ... staggering numbers of people worldwide. Recent advances in our molecular understanding of cholesterol and ... fasted and active/sedentary states. Key surprises include the unexpected nature of many pivotal molecular ...
| Abstract | Overconsumption of lipid-rich diets, in conjunction with physical inactivity, disables and kills staggering numbers of people worldwide. Recent advances in our molecular understanding of cholesterol and triglyceride transport from the small intestine to the rest of the body provide a detailed picture of the fed/fasted and active/sedentary states. Key surprises include the unexpected nature of many pivotal molecular mediators, as well as their dysregulation - but possible reversibility - in obesity, diabetes, inactivity, and related conditions. These mechanistic insights provide new opportunities to correct dyslipoproteinemia, accelerated atherosclerosis, insulin resistance, and other deadly sequelae of overnutrition and underexertion. |
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| MeSH term(s) | Animals ; Chylomicrons/metabolism ; Dietary Fats/metabolism ; Humans ; Intestine, Small/metabolism ; Lipid Metabolism ; Lipoproteins/metabolism ; Liver/metabolism | |||||
| Chemical Substances | Chylomicrons ; Dietary Fats ; Lipoproteins | |||||
| Language | English | |||||
| Publishing date | 2008-10 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 3067-3 | |||||
| ISSN | 1558-8238 ; 0021-9738 | |||||
| ISSN (online) | 1558-8238 | |||||
| ISSN | 0021-9738 | |||||
| DOI | 10.1172/JCI35206 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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