Article ; Online: Monitoring antibody response following SARS-CoV-2 infection: diagnostic efficiency of 4 automated immunoassays.
Diagnostic microbiology and infectious disease
2020 Volume 98, Issue 3, Page(s) 115140
Abstract: ... as contact tracing.: Material and methods: The antibody response against SARS-CoV-2 was examined in 111 patients ... Introduction: SARS-CoV-2 seroconversion is important for epidemiological studies as well ... on the measurement of SARS-CoV-2 antibodies in 96 residual samples collected during a non-pandemic period.: Results ...
| Abstract | Introduction: SARS-CoV-2 seroconversion is important for epidemiological studies as well as contact tracing. Material and methods: The antibody response against SARS-CoV-2 was examined in 111 patients with a positive qRT-PCR. Seroconversion was assessed using the Elecsys from Roche, the Liaison S1/S2 IgG from Diasorin, the IgG and IgA from Euroimmun, as well as the VIDAS IgG and IgM. Specificity was estimated based on the measurement of SARS-CoV-2 antibodies in 96 residual samples collected during a non-pandemic period. Results: The highest overall sensitivity for detecting seroconversion was obtained using the Elecsys (81.1%), the Euroimmun with a combined detection of IgG/IgA (86.5%), and the VIDAS with a simultaneous measurement of IgG/IgM (78.4%).The Elecsys and the VIDAS IgG/IgM demonstrated a specificity as well as a positive predictive value of 100%. Conclusions: The Elecsys and the VIDAS methods with a combination of IgG/IgM measurement demonstrated a high sensitivity with no false positive results. |
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| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Antibody Formation/immunology ; Betacoronavirus/immunology ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Female ; Humans ; Immunoassay/methods ; Immunoglobulin A/blood ; Immunoglobulin A/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunoglobulin M/blood ; Immunoglobulin M/immunology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Polymerase Chain Reaction ; SARS-CoV-2 ; Seroconversion ; Serologic Tests/methods ; Young Adult |
| Chemical Substances | Antibodies, Viral ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-07-12 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 604920-5 |
| ISSN | 1879-0070 ; 0732-8893 |
| ISSN (online) | 1879-0070 |
| ISSN | 0732-8893 |
| DOI | 10.1016/j.diagmicrobio.2020.115140 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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