Article ; Online: Recovery of TRIM25-Mediated RIG-I Ubiquitination through Suppression of NS1 by RNA Aptamers.
2019 Volume 42, Issue 10, Page(s) 721–728
Abstract: ... aptamers specific to NS1 with ... Non-structural protein 1 (NS1) of influenza virus has been shown to inhibit ... the innate immune response by blocking the induction of interferon (IFN). In this study, we isolated two single-stranded RNA ...
| Abstract | Non-structural protein 1 (NS1) of influenza virus has been shown to inhibit the innate immune response by blocking the induction of interferon (IFN). In this study, we isolated two single-stranded RNA aptamers specific to NS1 with |
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| MeSH term(s) | Animals ; Aptamers, Nucleotide/metabolism ; DEAD Box Protein 58/metabolism ; HEK293 Cells ; Humans ; Interferons/metabolism ; Mice ; Protein Binding ; RAW 264.7 Cells ; Receptors, Immunologic ; Transcription Factors/metabolism ; Tripartite Motif Proteins/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; Viral Nonstructural Proteins/metabolism ; Virus Replication | |||||
| Chemical Substances | Aptamers, Nucleotide ; Receptors, Immunologic ; Transcription Factors ; Tripartite Motif Proteins ; Viral Nonstructural Proteins ; Interferons (9008-11-1) ; TRIM25 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; RIGI protein, human (EC 3.6.1.-) ; DEAD Box Protein 58 (EC 3.6.4.13) | |||||
| Keywords | covid19 | |||||
| Language | English | |||||
| Publishing date | 2019-07-08 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1148964-9 | |||||
| ISSN | 0219-1032 ; 1016-8478 | |||||
| ISSN (online) | 0219-1032 | |||||
| ISSN | 1016-8478 | |||||
| DOI | 10.14348/molcells.2019.0157 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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