Article: Interferon production by leukocytes infiltrating the lungs of mice during primary influenza virus infection.
1982 Volume 38, Issue 3, Page(s) 1249–1255
Abstract: ... after infection with influenza A/Hong Kong/68 virus and were tested for interferon activity. Lavage ... leukocytes from lungs of uninfected mice, washed leukocytes obtained from the lungs of mice infected 2 to 6 ... presence and significant numbers of interferon-producing leukocytes in infected lungs suggests ...
| Abstract | Lung fluids and leukocytes were obtained from unprimed C3H mice by transpleural lavage at intervals after infection with influenza A/Hong Kong/68 virus and were tested for interferon activity. Lavage fluid interferon titers correlated directly with lung virus titers and with initial increases in leukocyte yields from infected lungs. In contrast to cultured lymph node cells from infected animals or leukocytes from lungs of uninfected mice, washed leukocytes obtained from the lungs of mice infected 2 to 6 days earlier produced interferon spontaneously in culture. The physiochemical, biological, and antigenic properties of both the interferon in lavage fluids and that produced by lung lavage leukocytes were similar and characteristics of alpha interferon. Fractionation studies indicated that macrophages and T lymphocytes were primarily responsible for the interferon produced in culture. The early presence and significant numbers of interferon-producing leukocytes in infected lungs suggests that these cells have an early role in defense against influenza virus infection. |
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| MeSH term(s) | Animals ; Cytopathogenic Effect, Viral ; Influenza A virus/growth & development ; Interferon Type I/analysis ; Interferon Type I/biosynthesis ; L Cells ; Leukocytes/metabolism ; Lung/analysis ; Lung/pathology ; Macrophages/metabolism ; Mice ; Mice, Inbred C3H ; Orthomyxoviridae/growth & development ; Orthomyxoviridae Infections/metabolism ; Orthomyxoviridae Infections/pathology ; T-Lymphocytes/metabolism ; Vesicular stomatitis Indiana virus/physiology | |||||
| Chemical Substances | Interferon Type I | |||||
| Language | English | |||||
| Publishing date | 1982-12 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, U.S. Gov't, P.H.S. | |||||
| ZDB-ID | 218698-6 | |||||
| ISSN | 1098-5522 ; 0019-9567 | |||||
| ISSN (online) | 1098-5522 | |||||
| ISSN | 0019-9567 | |||||
| DOI | 10.1128/iai.38.3.1249-1255.1982 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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