Article ; Online: ncRNA-regulated immune response and its role in inflammatory lung diseases.
American journal of physiology. Lung cellular and molecular physiology
2015 Volume 309, Issue 10, Page(s) L1076–87
Abstract: ... of this regulatory network. Abnormal immune response serves a central role in the initiation, progression, and ... of inflammatory lung diseases via their regulation of pulmonary immunity. We also discussed therapeutic potentials ... exacerbation of inflammatory lung diseases, such as asthma, chronic obstructive pulmonary disease ...
| Abstract | Despite the greatly expanded knowledge on the regulation of immune response by protein molecules, there is increasing understanding that noncoding RNAs (ncRNAs) are also an integral component of this regulatory network. Abnormal immune response serves a central role in the initiation, progression, and exacerbation of inflammatory lung diseases, such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, and acute respiratory distress syndrome/acute lung injury. Dysregulation of ncRNAs has been linked to various immunopathologies. In this review, we highlighted the role of ncRNAs in the regulation of innate and adaptive immunity and summarized recent findings that ncRNAs participate in the pathogenesis of inflammatory lung diseases via their regulation of pulmonary immunity. We also discussed therapeutic potentials for targeting ncRNAs to treat these lung disorders. |
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| MeSH term(s) | Adaptive Immunity ; Animals ; Asthma/genetics ; Asthma/immunology ; Asthma/metabolism ; Cystic Fibrosis/genetics ; Cystic Fibrosis/immunology ; Cystic Fibrosis/metabolism ; Humans ; Immunity, Innate ; Lung/immunology ; Lung/metabolism ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/immunology ; Pulmonary Disease, Chronic Obstructive/metabolism ; RNA Interference ; RNA, Untranslated/physiology ; Respiratory Distress Syndrome/genetics ; Respiratory Distress Syndrome/immunology ; Respiratory Distress Syndrome/metabolism | ||||||||||
| Chemical Substances | RNA, Untranslated | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2015-10-02 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Review | ||||||||||
| ZDB-ID | 1013184-x | ||||||||||
| ISSN | 1522-1504 ; 1040-0605 | ||||||||||
| ISSN (online) | 1522-1504 | ||||||||||
| ISSN | 1040-0605 | ||||||||||
| DOI | 10.1152/ajplung.00286.2015 | ||||||||||
| Shelf mark |
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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