Article: Breach of IL-12 monopoly in the initiation of type 1 immunity to intracellular infections: IL-12 is not required.
Cellular and molecular biology (Noisy-le-Grand, France)
2001 Volume 47, Issue 4, Page(s) 689–694
Abstract: ... evidence that while IL- 12 is critically required for the development of type 1 immunity to the majority ... of intracellular bacterial, parasitic and fungal infections, it is not required for anti-viral type 1 ... immune responses. These findings have provoked our re-thinking about the role of IL-12 in type 1 immunity and ...
| Abstract | IL-12 is believed to play an important role in type 1 T-cell differentiation and type 1 cytokine IFN-gamma release by T- and NK-cells and macrophages in host defense against intracellular infections by bacteria, parasites, fungi and viruses. However, recent studies by us and others have provided unequivocal evidence that while IL- 12 is critically required for the development of type 1 immunity to the majority of intracellular bacterial, parasitic and fungal infections, it is not required for anti-viral type 1 immune responses. These findings have provoked our re-thinking about the role of IL-12 in type 1 immunity and the search for additional cytokines capable of initiating anti-viral type 1 immunity. We hypothesize that there exist multiple cytokines including IL-12 which play a redundant role in the initiation of type 1 immunity against viral infection. These cytokines are likely released from not only antigen-presenting macrophages/dendritic cells but many other cell types, which suits the mode of viral infection. The existence of multiple factors capable of driving type 1 immunity endows the host with additional safeguards to cope with prevalent viral foes. |
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| MeSH term(s) | Animals ; Bacterial Infections/immunology ; Humans ; Influenza, Human/immunology ; Interferon-gamma/biosynthesis ; Interleukin-12/immunology ; Lymphocytic Choriomeningitis/immunology ; Mycoses/immunology ; Parasitic Diseases/immunology ; Th1 Cells/immunology ; Virus Diseases/immunology | |||||
| Chemical Substances | Interleukin-12 (187348-17-0) ; Interferon-gamma (82115-62-6) | |||||
| Language | English | |||||
| Publishing date | 2001-06 | |||||
| Publishing country | France | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 1161779-2 | |||||
| ISSN | 0145-5680 | |||||
| ISSN | 0145-5680 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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