Article ; Online: Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.
ACS infectious diseases
2020 Volume 6, Issue 5, Page(s) 909–915
Abstract: ... as an antiviral agent. In this brief review, we summarize the broad antiviral activity of niclosamide and highlight ... potency such as SARS-CoV, MERS-CoV, ZIKV, HCV, and human adenovirus, indicating its potential ... for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved ...
| Abstract | The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various viral infections with nanomolar to micromolar potency such as SARS-CoV, MERS-CoV, ZIKV, HCV, and human adenovirus, indicating its potential as an antiviral agent. In this brief review, we summarize the broad antiviral activity of niclosamide and highlight its potential clinical use in the treatment of COVID-19. |
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| MeSH term(s) | Antiviral Agents/pharmacology ; Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Drug Repositioning ; Humans ; Middle East Respiratory Syndrome Coronavirus/drug effects ; Niclosamide/pharmacology ; Pandemics ; Pneumonia, Viral/drug therapy ; Severe acute respiratory syndrome-related coronavirus/drug effects ; SARS-CoV-2 ; COVID-19 Drug Treatment |
| Chemical Substances | Antiviral Agents ; Niclosamide (8KK8CQ2K8G) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-03-10 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Review |
| ISSN | 2373-8227 |
| ISSN (online) | 2373-8227 |
| DOI | 10.1021/acsinfecdis.0c00052 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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