Article ; Online: Salvianolic acid B protects against acute lung injury by decreasing TRPM6 and TRPM7 expressions in a rat model of sepsis.
Journal of cellular biochemistry
2017 Volume 119, Issue 1, Page(s) 701–711
Abstract: ... on acute lung injury (ALI) through decreasing the expressions of channel kinase's TRPM6 and TRPM7. Wistar Septic rat ... lipopolysaccharide (LPS), SA-B, SA-B + si-TRPM6, SA-B + si-TRPM7, si-TRPM6, and si-TRPM7 groups. Arterial blood gas ... and SOD kit. The mRNA expressions of TRPM6 and TRPM7 were detected by qRT-PCR. Compared ...
| Abstract | This study aimed to investigate the protective effects of salvianolic acid B (SA-B) on acute lung injury (ALI) through decreasing the expressions of channel kinase's TRPM6 and TRPM7. Wistar Septic rat models were established by lipopolysaccharide (LPS), which were separated into the control, lipopolysaccharide (LPS), SA-B, SA-B + si-TRPM6, SA-B + si-TRPM7, si-TRPM6, and si-TRPM7 groups. Arterial blood gas, protein content, total white blood cell (WBC) count and the percentage of polymorphonuclear neutrophils (PMN%) were measured. Levels of TNF-α and IL-6 levels in bronchoalveolar lavage fluid (BALF) were monitored. Lung coefficient, myeloperoxidase (MPO) and superoxide dismutase (SOD) activity were conducted by MPO and SOD kit. The mRNA expressions of TRPM6 and TRPM7 were detected by qRT-PCR. Compared with the control group, the PaO |
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| MeSH term(s) | Acute Lung Injury/etiology ; Acute Lung Injury/prevention & control ; Animals ; Benzofurans/administration & dosage ; Benzofurans/pharmacology ; Bronchoalveolar Lavage Fluid/immunology ; Disease Models, Animal ; Down-Regulation ; Gene Expression Regulation/drug effects ; Interleukin-6/metabolism ; Lipopolysaccharides/adverse effects ; Male ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Rats ; Rats, Wistar ; Sepsis/chemically induced ; Sepsis/drug therapy ; Sepsis/genetics ; Sepsis/metabolism ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism ; Tumor Necrosis Factor-alpha/metabolism | |||||
| Chemical Substances | Benzofurans ; Interleukin-6 ; Lipopolysaccharides ; TRPM Cation Channels ; TRPM6 protein, human ; Tumor Necrosis Factor-alpha ; interleukin-6, mouse ; salvianolic acid B (C1GQ844199) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; TRPM7 protein, human (EC 2.7.11.1) | |||||
| Language | English | |||||
| Publishing date | 2017-08-02 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 392402-6 | |||||
| ISSN | 1097-4644 ; 0730-2312 | |||||
| ISSN (online) | 1097-4644 | |||||
| ISSN | 0730-2312 | |||||
| DOI | 10.1002/jcb.26233 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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