Article ; Online: Colon ischemia in patients with severe COVID-19: a single-center retrospective cohort study of 20 patients.
International journal of colorectal disease
2021 Volume 36, Issue 12, Page(s) 2769–2773
Abstract: ... Conclusion: In this cohort study of patients with severe COVID-19 and colonic ischemia, clinical ... included of whom 20 (10.5%) patients underwent surgery for colon ischemia. Preoperatively, D-dimer was ... with severe COVID-19, requiring critical care and surgical treatment of colonic ischemia, were included ...
| Abstract | Purpose: Thromboembolic complications due to COVID-19 are common in patients requiring critical care and are associated with high morbidity and mortality rates. The aim of this study was to evaluate clinical manifestations and postoperative outcomes after colectomy for COVID-19-associated colonic ischemia in the first versus the second wave of the pandemic. Methods: A retrospective cohort study of patients with severe COVID-19 at our institution between 1 March 2020 and 31 January 2021 was performed. All patients with severe COVID-19, requiring critical care and surgical treatment of colonic ischemia, were included. The main outcomes were surgical complications and mortality rate. Results: A total of 190 patients were included of whom 20 (10.5%) patients underwent surgery for colon ischemia. Preoperatively, D-dimer was elevated, especially in the first wave (median 15.24 (interquartile range 6.00-32.00) vs. 2.09 (1.42-4.28) mg/L, p = 0.025). Twelve (60%) patients underwent a (sub)total colectomy, 7 (35%) a right hemicolectomy, and one patient (5%) an ileocecal resection. Grade 3b complications occurred in one of 5 patients (20%) in the first and in 9 of 15 patients (60%) in the second wave. The overall in-hospital mortality was similar in both waves (40% vs. 47%), with death occurring after a median stay of 21 days. Conclusion: In this cohort study of patients with severe COVID-19 and colonic ischemia, clinical presentation and laboratory findings varied. However, the majority of patients required (sub)total colectomy. Despite a lower threshold to surgery in the second wave, mortality remained high. |
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| MeSH term(s) | COVID-19 ; Cohort Studies ; Colectomy ; Colon/surgery ; Humans ; Ischemia/surgery ; Retrospective Studies ; SARS-CoV-2 | |||||
| Language | English | |||||
| Publishing date | 2021-07-29 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 84975-3 | |||||
| ISSN | 1432-1262 ; 0179-1958 | |||||
| ISSN (online) | 1432-1262 | |||||
| ISSN | 0179-1958 | |||||
| DOI | 10.1007/s00384-021-03999-3 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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