Article: Association Between the Concentration and Rangeability of Cystatin C and Mortality of COVID-19 Patients With or Without Type 2 Diabetes Mellitus: A Retrospective Analysis.
2021 Volume 12, Page(s) 642452
Abstract: ... from, type 2 diabetes mellitus (T2DM).: Methods: A total of 675 T2DM patients and 572 non-T2DM patients ... Background: We investigated if the concentration and "rangeability" of cystatin C (CysC ... with those with a low level or low rangeability of CysC. Patients with a higher level and rangeability of CysC had more ...
| Abstract | Background: We investigated if the concentration and "rangeability" of cystatin C (CysC) influenced the prognosis of coronavirus disease 2019 (COVID-19) in patients suffering from, or not suffering from, type 2 diabetes mellitus (T2DM). Methods: A total of 675 T2DM patients and 572 non-T2DM patients were divided into "low" and "high" CysC groups and low and high CysC-rangeability groups according to serum CysC level and range of change of CysC level, respectively. Demographic characteristics, clinical data, and laboratory results of the four groups were analyzed. Results: COVID-19 patients with a high level and rangeability of CysC had more organ damage and a higher risk of death compared with those with a low level or low rangeability of CysC. Patients with a higher level and rangeability of CysC had more blood lymphocytes and higher levels of C-reactive protein, alanine aminotransferase, and aspartate aminotransferase. After adjustment for possible confounders, multivariate analysis revealed that CysC >0.93 mg/dL was significantly associated with the risk of heart failure (OR = 2.231, 95% CI: 1.125-5.312) and all-cause death (2.694, 1.161-6.252). CysC rangeability >0 was significantly associated with all-cause death (OR = 4.217, 95% CI: 1.953-9.106). These associations were stronger in patients suffering from T2DM than in those not suffering from T2DM. Conclusions: The level and rangeability of CysC may influence the prognosis of COVID-19. Special care and appropriate intervention should be undertaken in COVID-19 patients with an increased CysC level during hospitalization and follow-up, especially for those with T2DM. |
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| MeSH term(s) | Aged ; Biomarkers/blood ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19/virology ; Case-Control Studies ; Cystatin C/blood ; Diabetes Mellitus, Type 2/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Factors ; SARS-CoV-2/isolation & purification |
| Chemical Substances | Biomarkers ; CST3 protein, human ; Cystatin C |
| Language | English |
| Publishing date | 2021-06-21 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2592084-4 |
| ISSN | 1664-2392 |
| ISSN | 1664-2392 |
| DOI | 10.3389/fendo.2021.642452 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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