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Artikel ; Online: Prognostic Value of Electrophysiologic Study in Drug-Induced Brugada Syndrome: Caution is Always a Must.

Dendramis, Gregory / D'Onofrio, Antonio / Russo, Vincenzo

2021 Band 163, Seite(n) 143

Mesh-Begriff(e)	Brugada Syndrome/chemically induced ; Brugada Syndrome/diagnosis ; Bundle-Branch Block ; Electrophysiologic Techniques, Cardiac ; Humans ; Pharmaceutical Preparations ; Prognosis
Chemische Substanzen	Pharmaceutical Preparations
Sprache	Englisch
Erscheinungsdatum	2021-11-08
Erscheinungsland	United States
Dokumenttyp	Letter ; Comment
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2021.10.015
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Risk of arrhythmic events in drug-induced Brugada syndrome.

Lahrouchi, Najim / Talajic, Mario / Tadros, Rafik

Heart rhythm

2017 Band 14, Heft 10, Seite(n) 1434–1435

Mesh-Begriff(e)	Brugada Syndrome ; Electrocardiography ; Humans ; Risk ; Risk Factors
Sprache	Englisch
Erscheinungsdatum	2017
Erscheinungsland	United States
Dokumenttyp	Editorial ; Comment
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2017.06.033
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Long-term prognosis of drug-induced Brugada syndrome.

Sieira, Juan / Ciconte, Giuseppe / Conte, Giulio / de Asmundis, Carlo / Chierchia, Gian-Battista / Baltogiannis, Giannis / Di Giovanni, Giacomo / Saitoh, Yukio / Casado-Arroyo, Ruben / Juliá, Justo / La Meir, Mark / Wellens, Francis / Wauters, Kristel / Pappaert, Gudrun / Brugada, Pedro

Heart rhythm

2017 Band 14, Heft 10, Seite(n) 1427–1433

Abstract: Background: Patients with drug-induced Brugada syndrome (BS) are considered at a lower risk ... Methods: A consecutive cohort of 343 patients with drug-induced BS was included and compared with 78 ... asymptomatic. Patients with drug-induced BS were less frequently men (180 (52.5%) vs 63 (80.8%); P < .01), were ...

Abstract	Background: Patients with drug-induced Brugada syndrome (BS) are considered at a lower risk than those with a spontaneous type I pattern. Nevertheless, they can present arrhythmic events. Objective: The purpose of this study was to investigate their clinical characteristics, long-term prognosis and risk factors. Methods: A consecutive cohort of 343 patients with drug-induced BS was included and compared with 78 patients with a spontaneous type I pattern. Results: The mean age was 40.7 ± 18.3 years. Sudden cardiac death (SCD) was the clinical presentation in 13 (3.8%) and syncope in 86 (25.1%); 244 (71.1%) were asymptomatic. Patients with drug-induced BS were less frequently men (180 (52.5%) vs 63 (80.8%); P < .01), were more frequently asymptomatic (244 (71.1%) vs 44 (56.4%); P < .01), and had less ventricular arrhythmias (VAs) induced during electrophysiology study (41 (13.2%) vs 31 (42.4%); P < .01). An implantable cardioverter-defibrillator was implanted in 128 patients (37.3%). During a median follow-up of 62.5 months (interquartile range 28.9-115.6 months), 34 patients presented arrhythmic events. The event rate was 1.1% person-year (vs 2.3% person-year in patients with a spontaneous type I pattern; P < .01). Presentation as SCD and inducible VAs were independent risk factors significantly associated with arrhythmic events (adjusted hazard ratio 22.0 and 3.5). Drug-induced BS was related to a better prognosis only in asymptomatic individuals. Conclusion: Drug-induced BS has a good prognosis if asymptomatic; however, SCD is possible. Clinical presentation as SCD and inducible VAs during electrophysiology study are independent risk factors for arrhythmic events. In asymptomatic patients, proband status and inducible VAs can help to identify patients at higher risk, but further evidence is needed.
Mesh-Begriff(e)	Adolescent ; Adult ; Aged ; Ajmaline/administration & dosage ; Ajmaline/adverse effects ; Anti-Arrhythmia Agents/administration & dosage ; Anti-Arrhythmia Agents/adverse effects ; Belgium/epidemiology ; Brugada Syndrome/chemically induced ; Brugada Syndrome/epidemiology ; Brugada Syndrome/therapy ; Child ; Child, Preschool ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/prevention & control ; Defibrillators, Implantable ; Electrocardiography ; Female ; Follow-Up Studies ; Forecasting ; Humans ; Incidence ; Infant ; Injections, Intravenous ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Risk Factors ; Survival Rate/trends ; Time Factors ; Young Adult
Chemische Substanzen	Anti-Arrhythmia Agents ; Ajmaline (1PON08459R)
Sprache	Englisch
Erscheinungsdatum	2017
Erscheinungsland	United States
Dokumenttyp	Comparative Study ; Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2017.04.044
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Drug-induced Brugada syndrome.

Yap, Yee Guan / Behr, Elijah R / Camm, A John

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2009 Band 11, Heft 8, Seite(n) 989–994

Abstract: ... possible that drug-induced Brugada syndrome may be due to an individual susceptibility that favours drug ... In this paper, we will review the cases and evidence of drug-induced Brugada syndrome reported in the literature. ... to that in drug-induced long QT syndrome. However, further evidence is needed to confirm this postulation ...

Abstract	Brugada syndrome is an inherited cardiac arrhythmia condition characterized by (i) coved ST-elevation and J point elevation of at least 2 mm in at least two of the right precordial ECG leads (V1-V3) and (ii) ventricular arrhythmias, syncope, and sudden death. Patients with Brugada syndrome or suspected mutation carriers can have normal ECG recordings at other times. In these cases, a diagnostic challenge with a sodium channel blocker such as ajmaline, flecainide, or pilsicainide may induce the full-blown type 1 ECG pattern and support the diagnosis. However, recently, many other pharmacological agents not related to class I anti-arrhythmic agents have been reported to induce Brugada ECG patterns including tricyclic antidepressants, fluoxetine, lithium, trifluoperazine, antihistamines, and cocaine. As published reports of the drug-induced Brugada sign have become increasingly prevalent, there is growing interest in the mechanisms responsible for this acquired ECG pattern and its clinical significance. It is possible that drug-induced Brugada syndrome may be due to an individual susceptibility that favours drug-induced ECG abnormalities, possibly as a result of an increase in a latent ion channel dysfunction similar to that in drug-induced long QT syndrome. However, further evidence is needed to confirm this postulation. In this paper, we will review the cases and evidence of drug-induced Brugada syndrome reported in the literature.
Mesh-Begriff(e)	Anti-Arrhythmia Agents/adverse effects ; Brugada Syndrome/chemically induced ; Brugada Syndrome/prevention & control ; Cardiotonic Agents/adverse effects ; Heart Conduction System/drug effects ; Humans
Chemische Substanzen	Anti-Arrhythmia Agents ; Cardiotonic Agents
Sprache	Englisch
Erscheinungsdatum	2009-08
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/eup114
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Drug-induced Brugada syndrome: Clinical characteristics and risk factors.

Konigstein, Maayan / Rosso, Raphael / Topaz, Guy / Postema, Pieter G / Friedensohn, Limor / Heller, Karin / Zeltser, David / Belhassen, Bernard / Adler, Arnon / Viskin, Sami

Heart rhythm

2016 Band 13, Heft 5, Seite(n) 1083–1087

Abstract: ... but not necessarily less important form of drug-induced proarrhythmia is the drug-induced Brugada syndrome ... Brugada syndrome.: Methods: Reports of drug-induced Brugada syndrome recounted by an international database ... to developing this complication. For each patient with drug-induced Brugada syndrome who had an ECG recorded ...

Abstract	Background: Cardiac arrest may result from seemingly innocuous medications that do not necessarily have cardiac indications. The best-known example is the drug-induced long QT syndrome. A less known but not necessarily less important form of drug-induced proarrhythmia is the drug-induced Brugada syndrome. Objective: The purpose of this study was to identify clinical and ECG risk markers for drug-induced Brugada syndrome. Methods: Reports of drug-induced Brugada syndrome recounted by an international database (http://www.brugadadrugs.org) were reviewed to define characteristics that identify patients prone to developing this complication. For each patient with drug-induced Brugada syndrome who had an ECG recorded in the absence of drugs, we included 5 healthy controls matched by gender and age. All ECGs were evaluated for Brugada-like abnormalities. Results: Seventy-four cases of drug-induced Brugada syndrome from noncardiac medications were identified: 77% were male, and drug toxicity was involved in 46%. Drug-induced Brugada syndrome from oral medications generally occurred weeks after the initiation of therapy. Mortality was 13%. By definition, all cases had a type I Brugada pattern during drug therapy. Nevertheless, their ECG in the absence of drugs was more frequently abnormal than the ECG of controls (56% vs 33%, P = .04). Conclusion: Drug-induced Brugada syndrome from noncardiac drugs occurs predominantly in adult males, is frequently due to drug toxicity, and occurs late after the onset of therapy. Minor changes are frequently noticeable on baseline ECG, but screening is impractical because of a prohibitive false-positive rate.
Mesh-Begriff(e)	Adult ; Age Factors ; Brugada Syndrome/chemically induced ; Brugada Syndrome/diagnosis ; Brugada Syndrome/epidemiology ; Dose-Response Relationship, Drug ; Drug Administration Routes ; Drug Interactions ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Electrocardiography/methods ; Female ; Heart Conduction System/drug effects ; Heart Diseases/epidemiology ; Humans ; Male ; Mass Screening/methods ; Middle Aged ; Risk Factors ; Sex Factors
Sprache	Englisch
Erscheinungsdatum	2016-03-24
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2016.03.016
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Drug-induced Brugada syndrome by noncardiac agents.

Letsas, Konstantinos P / Kavvouras, Charalampos / Kollias, George / Tsikrikas, Spyridon / Korantzopoulos, Panagiotis / Efremidis, Michalis / Sideris, Antonios

Pacing and clinical electrophysiology : PACE

2013 Band 36, Heft 12, Seite(n) 1570–1577

Abstract: Drug-induced Brugada syndrome (BrS) represents a great challenge for the prescribing clinicians ... to induce the characteristic Brugada electrocardiogram pattern predisposing to fatal ventricular arrhythmias ... responsible with monitoring drug safety. Apart from well-known cardiac agents (mainly Class I antiarrhythmics ...

Abstract	Drug-induced Brugada syndrome (BrS) represents a great challenge for the prescribing clinicians as well as for those involved in the development of novel pharmaceuticals and in the regulatory bodies responsible with monitoring drug safety. Apart from well-known cardiac agents (mainly Class I antiarrhythmics), an increasing number of noncardiac agents, including psychotropic and anesthetic drugs, have been shown to induce the characteristic Brugada electrocardiogram pattern predisposing to fatal ventricular arrhythmias. Up to now, both repolarization and depolarization abnormalities are thought to be related to the development of ventricular fibrillation in BrS patients. This review highlights the mechanisms and the noncardiac medical agents that unmask a genetic predisposition to BrS.
Mesh-Begriff(e)	Anesthetics/adverse effects ; Brugada Syndrome/chemically induced ; Brugada Syndrome/genetics ; Brugada Syndrome/prevention & control ; Cardiovascular Agents/adverse effects ; Electrocardiography/drug effects ; Genetic Predisposition to Disease/genetics ; Genetic Predisposition to Disease/prevention & control ; Humans ; Psychotropic Drugs/adverse effects
Chemische Substanzen	Anesthetics ; Cardiovascular Agents ; Psychotropic Drugs
Sprache	Englisch
Erscheinungsdatum	2013-12
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.12234
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Subcutaneous implantable cardioverter-defibrillator and drug-induced Brugada syndrome: the importance of repeat morphology analysis during ajmaline challenge.

Conte, Giulio / Regoli, Francois / Moccetti, Tiziano / Auricchio, Angelo

European heart journal

2016 Band 37, Heft 19, Seite(n) 1498

Sprache	Englisch
Erscheinungsdatum	2016-05-14
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehv572
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Drug-induced brugada syndrome in children: clinical features, device-based management, and long-term follow-up.

Conte, Giulio / Dewals, Wendy / Sieira, Juan / de Asmundis, Carlo / Ciconte, Giuseppe / Chierchia, Gian-Battista / Di Giovanni, Giacomo / Baltogiannis, Giannis / Saitoh, Yukio / Levinstein, Moises / La Meir, Mark / Wellens, Francis / Pappaert, Gudrun / Brugada, Pedro

Journal of the American College of Cardiology

2014 Band 63, Heft 21, Seite(n) 2272–2279

Abstract: ... term follow-up of children with drug-induced Brugada syndrome (BS).: Background: Patients with BS ... Data on drug-induced BS in patients <12 years of age are lacking.: Methods: Among 505 patients ... Conclusions: Drug-induced BS is associated with atrial arrhythmias and SND. Children are at higher risk ...

Abstract	Objectives: The goal of this study was to investigate the clinical features, management, and long-term follow-up of children with drug-induced Brugada syndrome (BS). Background: Patients with BS <12 years of age with a spontaneous type I electrocardiogram have a higher risk of arrhythmic events. Data on drug-induced BS in patients <12 years of age are lacking. Methods: Among 505 patients with ajmaline-induced BS, subjects ≤12 years of age at the time of diagnosis were considered as children and eligible for this study. Results: Forty children (60% male; age 8 ± 2.8 years) were included. Twenty-four children (60%) had a family history of sudden death. Two (5%) had a previous episode of aborted sudden death, and 8 (20%) had syncope. Children experienced more frequent episodes of sinus node dysfunction (SND) compared with older subjects (7.5% vs. 1.5%; p = 0.04) and had a comparable incidence of atrial tachyarrhythmias. Children more frequently experienced episodes of ajmaline-induced sustained ventricular arrhythmias (VAs) compared with older patients (10.0% vs. 1.3%; p = 0.005). Twelve children (30%) received an implantable cardioverter-defibrillator (ICD). After a mean follow-up time of 83 ± 51 months, none of the children died suddenly. Spontaneous sustained VAs were documented in 1 child (2%). Among children with ICD, 1 (8%) experienced an appropriate shock, 4 (33%) had inappropriate ICD shocks, and 4 (33%) experienced device-related complications. Conclusions: Drug-induced BS is associated with atrial arrhythmias and SND. Children are at higher risk of ajmaline-induced VAs. The rate of device-related complications, leading to lead replacement or inappropriate shocks, is considerable and even higher than with appropriate interventions. Based on these findings, the optimal management of BS in childhood should remain individualized, taking into consideration the patient's clinical history and family's wishes.
Mesh-Begriff(e)	Ajmaline/adverse effects ; Anti-Arrhythmia Agents/adverse effects ; Brugada Syndrome/chemically induced ; Brugada Syndrome/diagnosis ; Brugada Syndrome/therapy ; Child ; Defibrillators, Implantable/trends ; Disease Management ; Female ; Follow-Up Studies ; Humans ; Male ; Prospective Studies ; Registries ; Time Factors ; Treatment Outcome
Chemische Substanzen	Anti-Arrhythmia Agents ; Ajmaline (1PON08459R)
Sprache	Englisch
Erscheinungsdatum	2014-06-03
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2014.02.574
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Drug-induced Brugada syndrome.

Goethals, P / Debruyne, P / Saffarian, M

Acta cardiologica

1998 Band 53, Heft 3, Seite(n) 157–160

Abstract: ... right bundle-branch block (RBBB) and ST-segment elevation in the precordial leads V1-V3. This syndrome is named after ... for intermittent RBBB and ST-segment elevation. Because the syndrome is mostly familial and inherited ... Brugada who first described a clinical series. This paper stresses the dynamic changes and the spontaneous ...

Abstract	Survivors of sudden death without structural heart disease and a normal coronary angiogram are often diagnosed with idiopathic ventricular fibrillation (VF). The criteria for idiopathic VF have been reviewed elsewhere. However, a careful analysis of the electrocardiogram (ECG) is essential in the differential diagnosis of unexplained sudden cardiac death. We report two patients with unexplained VF, intermittent right bundle-branch block (RBBB) and ST-segment elevation in the precordial leads V1-V3. This syndrome is named after Brugada who first described a clinical series. This paper stresses the dynamic changes and the spontaneous normalization of the ECG. Class I drugs can unmask this peculiar ECG-pattern and can sometimes precipitate an arrhythmia if they are given chronically. Patients with the diagnosis of idiopathic VF should be screened for intermittent RBBB and ST-segment elevation. Because the syndrome is mostly familial and inherited as an autosomal dominant trait, diagnosis of this entity in a patient has an implication for the screening of family members.
Mesh-Begriff(e)	Aged ; Bundle-Branch Block/complications ; Bundle-Branch Block/diagnosis ; Death, Sudden, Cardiac ; Electrocardiography ; Heart Arrest/diagnosis ; Heart Arrest/etiology ; Heart Function Tests ; Humans ; Male ; Middle Aged ; Syncope/etiology ; Syndrome ; Ventricular Fibrillation/complications ; Ventricular Fibrillation/diagnosis
Sprache	Englisch
Erscheinungsdatum	1998
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	390197-x
ISSN	0001-5385
ISSN	0001-5385
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Case report: Lamin A/C gene mutation in patient with drug-induced type 1 Brugada syndrome at high arrhythmic risk.

Russo, Vincenzo / Papaccioli, Giovanni / Maddaloni, Valeria / Caputo, Adriano / Pepe, Nicola / Rago, Anna / Maiorino, Michele / Golino, Paolo / Nigro, Gerardo

Frontiers in cardiovascular medicine

2023 Band 9, Seite(n) 1099508

Abstract: We report the case of drug-induced type 1 Brugada syndrome at high arrhythmic risk associated ...

Abstract	We report the case of drug-induced type 1 Brugada syndrome at high arrhythmic risk associated with Lamin A/C gene mutation.
Sprache	Englisch
Erscheinungsdatum	2023-01-10
Erscheinungsland	Switzerland
Dokumenttyp	Case Reports
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1099508
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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