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  1. Article ; Online: Caries-preventive effect of glass ionomer and resin-based fissure sealants on permanent teeth: a meta analysis.

    Yengopal, Veerasamy / Mickenautsch, Steffen / Bezerra, Ana C / Leal, Soraya C

    Journal of oral science

    2009  Volume 51, Issue 3, Page(s) 373–382

    Abstract: ... preventive effect of glass ionomer cement (GIC) in relation to resin-based fissure sealants. Nine English and ... of GIC and resin-based fissure sealant material. This systematic review with meta-analysis found no ... preventive effect was caries absence on sealed teeth. Of the 112 identified articles, 25 were selected ...

    Abstract The purpose of this quantitative systematic review was to appraise the evidence on the caries-preventive effect of glass ionomer cement (GIC) in relation to resin-based fissure sealants. Nine English and two Portuguese databases were searched (15 January 2008). Randomized clinical trials and systematic reviews were considered for inclusion. Trial exclusion criteria were: drop-out rates > 33%; no randomization; baseline differences in groups not statistically adjusted; and no clinically important outcomes were presented. Two authors reviewed the articles independently. The outcome measure for the caries preventive effect was caries absence on sealed teeth. Of the 112 identified articles, 25 were selected for review. Of these, 14 were excluded and 11 accepted (8 trials; 3 systematic reviews). The accepted reviews provided no evidence of superiority of either sealant material. Six trials were included for meta-analysis. The pooled odds ratio was 0.96, 95% CI 0.62-1.49, indicating no difference in the caries-preventive effect of GIC and resin-based fissure sealant material. This systematic review with meta-analysis found no evidence that either material was superior to the other in the prevention of dental caries. Thus, both materials appear equally suitable for clinical application as a fissure sealant material.
    MeSH term(s) Dental Caries/prevention & control ; Glass Ionomer Cements ; Humans ; Pit and Fissure Sealants/chemistry ; Pit and Fissure Sealants/therapeutic use ; Resin Cements
    Chemical Substances Glass Ionomer Cements ; Pit and Fissure Sealants ; Resin Cements
    Language English
    Publishing date 2009-07-15
    Publishing country Japan
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 1434462-2
    ISSN 1880-4926 ; 1343-4934
    ISSN (online) 1880-4926
    ISSN 1343-4934
    DOI 10.2334/josnusd.51.373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 189: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Effectiveness of Pit and Fissure Sealants for Preventing and Arresting Occlusal Caries in Primary Molars: A Systematic Review and Meta-Analysis.

    Lam, Phoebe P Y / Sardana, Divesh / Ekambaram, Manikandan / Lee, Gillian H M / Yiu, Cynthia K Y

    The journal of evidence-based dental practice

    2020  Volume 20, Issue 2, Page(s) 101404

    Abstract: ... when evaluated over 24 months between (1) resin-based sealant (RBS) and glass ionomer sealants (GIS) or resin ... Objective: The use of pit and fissure sealants have been well supported in permanent teeth, but no ... sealants in prevention and arrest of the pit and fissure occlusal caries in primary molars of children ...

    Abstract Objective: The use of pit and fissure sealants have been well supported in permanent teeth, but no concrete evidence is available to support this procedure in primary molars. This review aims to systematically assess randomized controlled trials and summarize the evidence on the effectiveness of different sealants in prevention and arrest of the pit and fissure occlusal caries in primary molars of children.
    Materials and methods: Four electronic databases were searched from inception to March 2018. Seven studies were included in the qualitative and quantitative syntheses. Two reviewers independently selected studies, extracted data, assessed risk of bias using the revised Cochrane risk of bias tool, and evaluated the certainty in the evidence adopting the Grading of Recommendations Assessment Development and Evaluation approach. Odds ratio and retention rate of different sealants were recalculated and analyzed.
    Results: This review identified no significant difference in the overall caries incidence and progression when evaluated over 24 months between (1) resin-based sealant (RBS) and glass ionomer sealants (GIS) or resin-modified GIS; (2) conventional and newly developed RBS; (3) autopolymerized and light-polymerized RBS; (4) RBS with topical fluoride application and topical fluoride alone; and (5) RBS with topical fluoride application and resin infiltration with topical fluoride application. The pooled estimates of the mean retention rates of RBS and GIS on primary molars over an 18-months period were 85.94% and 23.18%, respectively. The certainty in the evidence of each outcome was determined as low or very low mainly because of high risk of overall bias and imprecision.
    Conclusion: There are currently insufficient well-controlled randomized controlled clinical trials to determine whether sealants are beneficial in preventing or arresting noncavitated occlusal caries in the primary molars.
    MeSH term(s) Child ; Dental Caries ; Dentition, Permanent ; Fluorides, Topical ; Humans ; Molar ; Pit and Fissure Sealants
    Chemical Substances Fluorides, Topical ; Pit and Fissure Sealants
    Language English
    Publishing date 2020-01-29
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2056058-8
    ISSN 1532-3390 ; 1532-3382
    ISSN (online) 1532-3390
    ISSN 1532-3382
    DOI 10.1016/j.jebdp.2020.101404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5561: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Caries-Preventive Effect of High-Viscosity Glass Ionomer and Resin-Based Fissure Sealants on Permanent Teeth: A Systematic Review of Clinical Trials.

    Mickenautsch, Steffen / Yengopal, Veerasamy

    PloS one

    2016  Volume 11, Issue 1, Page(s) e0146512

    Abstract: ... preventive efficacy of HVGIC and resin-based sealants after a period of 48 months in permanent molar teeth ... to protect against dental carious lesions in occlusal pits and fissures than resin-based fissure sealants ... Background: Glass-ionomers are traditionally regarded to be inferior to resin as fissure sealants ...

    Abstract Background: Glass-ionomers are traditionally regarded to be inferior to resin as fissure sealants in protecting teeth from dental caries, due to their comparatively lower retention rate. Unlike low-viscosity glass-ionomers, high-viscosity glass-ionomer cements (HVGIC) are placed as sealants by pressing the material into pits and fissures with a petroleum-jelly-coated index finger. Hence, HVGIC sealants are assumed to penetrate pits and fissures deeper, resulting in a higher material retention rate, which may increase its caries-preventive effect.
    Methods: The aim of this review was to answer the question as to whether, in patients with fully erupted permanent molar teeth, HVGIC based fissure sealants are less effective to protect against dental carious lesions in occlusal pits and fissures than resin-based fissure sealants? A systematic literature search in eight databases was conducted. Heterogeneity of accepted trials and imprecision of the established evidence were assessed. Extracted sufficiently homogenous datasets were pooled by use of a random-effects meta-analysis. Internal trial validity was evaluated. The protocol of this systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO / Nr.: CRD42015016007).
    Results: Seven clinical trials were provisionally included for further review. Of these, one was excluded. Seven trial reports reporting on six trials were accepted. From these, 11 datasets were extracted and pooled in four meta-analyses. The results suggest no statistically significant differences after up to 48 months and borderline significant differences in favour of HVGIC sealants after 60 months (RR 0.29; 95% CI: 0.09-0.95; p = 0.04 / RD -0.07; 95% CI: -0.14, -0.01). The point estimates and upper confidence levels after 24, 36, 48 and 60 months of RR 1.36; RR 0.90; RR 0.62; RR 0.29 and 2.78; 1.67; 1.21; 0.95, respectively, further suggest a chronological trend in favour of HVGIC above resin-based sealants. The internal trial validity was judged to be low and the bias risk high for all trials. Imprecision of results was considered too high for clinical guidance.
    Conclusion: It can be concluded that: (i) Inferiority claims against HVGIC in comparison to resin-based sealants as current gold-standard are not supported by the clinical evidence; (ii) The clinical evidence suggests similar caries-preventive efficacy of HVGIC and resin-based sealants after a period of 48 months in permanent molar teeth but remains challenged by high bias risk; (iii) Evidence concerning a possible superiority of HVGIC above resin-based sealants after 60 months is poor (even if the high bias risk is disregarded) due to imprecision and requires corroboration through future research.
    MeSH term(s) Acrylic Resins/therapeutic use ; Child ; Dental Caries/prevention & control ; Female ; Glass Ionomer Cements/therapeutic use ; Humans ; Male ; Outcome Assessment, Health Care ; Pit and Fissure Sealants/therapeutic use ; Resin Cements/therapeutic use ; Silicon Dioxide/therapeutic use ; Tooth/pathology
    Chemical Substances Acrylic Resins ; Glass Ionomer Cements ; Pit and Fissure Sealants ; Resin Cements ; glass ionomer ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2016-01-22
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0146512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Caries-Preventive Effect of High-Viscosity Glass Ionomer and Resin-Based Fissure Sealants on Permanent Teeth

    Steffen Mickenautsch / Veerasamy Yengopal

    PLoS ONE, Vol 11, Iss 1, p e

    A Systematic Review of Clinical Trials.

    2016  Volume 0146512

    Abstract: ... to protect against dental carious lesions in occlusal pits and fissures than resin-based fissure sealants ... BACKGROUND:Glass-ionomers are traditionally regarded to be inferior to resin as fissure sealants ... as to whether, in patients with fully erupted permanent molar teeth, HVGIC based fissure sealants are less effective ...

    Abstract BACKGROUND:Glass-ionomers are traditionally regarded to be inferior to resin as fissure sealants in protecting teeth from dental caries, due to their comparatively lower retention rate. Unlike low-viscosity glass-ionomers, high-viscosity glass-ionomer cements (HVGIC) are placed as sealants by pressing the material into pits and fissures with a petroleum-jelly-coated index finger. Hence, HVGIC sealants are assumed to penetrate pits and fissures deeper, resulting in a higher material retention rate, which may increase its caries-preventive effect. METHODS:The aim of this review was to answer the question as to whether, in patients with fully erupted permanent molar teeth, HVGIC based fissure sealants are less effective to protect against dental carious lesions in occlusal pits and fissures than resin-based fissure sealants? A systematic literature search in eight databases was conducted. Heterogeneity of accepted trials and imprecision of the established evidence were assessed. Extracted sufficiently homogenous datasets were pooled by use of a random-effects meta-analysis. Internal trial validity was evaluated. The protocol of this systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO / Nr.: CRD42015016007). RESULTS:Seven clinical trials were provisionally included for further review. Of these, one was excluded. Seven trial reports reporting on six trials were accepted. From these, 11 datasets were extracted and pooled in four meta-analyses. The results suggest no statistically significant differences after up to 48 months and borderline significant differences in favour of HVGIC sealants after 60 months (RR 0.29; 95% CI: 0.09-0.95; p = 0.04 / RD -0.07; 95% CI: -0.14, -0.01). The point estimates and upper confidence levels after 24, 36, 48 and 60 months of RR 1.36; RR 0.90; RR 0.62; RR 0.29 and 2.78; 1.67; 1.21; 0.95, respectively, further suggest a chronological trend in favour of HVGIC above resin-based sealants. The internal trial validity was judged to be ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Caries-preventive effect of glass ionomer and resin-based fissure sealants on permanent teeth: An update of systematic review evidence.

    Mickenautsch, Steffen / Yengopal, Veerasamy

    BMC research notes

    2011  Volume 4, Page(s) 22

    Abstract: ... resin-based fissure sealants.: Conclusions: This overall outcome is in agreement with the conclusions ... outcome of the computed datasets suggest no difference between the caries-preventive effects of GIC- and ... from the English literature as to whether caries occurrence on pits and fissures of teeth sealed with either GIC or ...

    Abstract Background: This article constitutes a partial update of the original systematic review evidence by Yengopal et al. from 15 January 2008 (published in the Journal of Oral Science in 2009) with primary focus on research quality in regard to bias risk in trials. Its aim is to update the existing systematic review evidence from the English literature as to whether caries occurrence on pits and fissures of teeth sealed with either GIC or resin is the same.
    Methods: In addition to the 12 trials included during the original systematic review, 5 new trials were identified during the database search (up to 26 August 2010) and 2 further trials were included from a hand search and reference check. Of these, 3 trials were excluded and 16 were accepted for data extraction and quality assessment. The quality of accepted trials was assessed, using updated quality criteria, and the risk of bias was investigated in more depth than previously reported. In addition, the focus of quantitative synthesis was shifted to single datasets that were extracted from the accepted trials.
    Results: Twenty-six dichotomous and 4 continuous datasets were extracted. Meta-analysis and cumulative meta-analysis were used in combining clinically homogenous datasets. The overall outcome of the computed datasets suggest no difference between the caries-preventive effects of GIC- and resin-based fissure sealants.
    Conclusions: This overall outcome is in agreement with the conclusions of the original systematic review. Although the findings of the trials identified in this update may be considered to be less affected by attrition- and publication bias, their risk of selection- and detection-/performance bias is high. Thus, verification of the currently available results requires further high quality randomised control trials.
    Language English
    Publishing date 2011-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/1756-0500-4-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Caries-preventive effect of glass ionomer and resin-based fissure sealants on permanent teeth

    Yengopal Veerasamy / Mickenautsch Steffen

    BMC Research Notes, Vol 4, Iss 1, p

    An update of systematic review evidence

    2011  Volume 22

    Abstract: ... of GIC- and resin-based fissure sealants. Conclusions This overall outcome is in agreement ... extracted. Meta-analysis and cumulative meta-analysis were used in combining clinically homogenous datasets ... of teeth sealed with either GIC or resin is the same. Methods In addition to the 12 trials included during ...

    Abstract Abstract Background This article constitutes a partial update of the original systematic review evidence by Yengopal et al. from 15 January 2008 (published in the Journal of Oral Science in 2009) with primary focus on research quality in regard to bias risk in trials. Its aim is to update the existing systematic review evidence from the English literature as to whether caries occurrence on pits and fissures of teeth sealed with either GIC or resin is the same. Methods In addition to the 12 trials included during the original systematic review, 5 new trials were identified during the database search (up to 26 August 2010) and 2 further trials were included from a hand search and reference check. Of these, 3 trials were excluded and 16 were accepted for data extraction and quality assessment. The quality of accepted trials was assessed, using updated quality criteria, and the risk of bias was investigated in more depth than previously reported. In addition, the focus of quantitative synthesis was shifted to single datasets that were extracted from the accepted trials. Results Twenty-six dichotomous and 4 continuous datasets were extracted. Meta-analysis and cumulative meta-analysis were used in combining clinically homogenous datasets. The overall outcome of the computed datasets suggest no difference between the caries-preventive effects of GIC- and resin-based fissure sealants. Conclusions This overall outcome is in agreement with the conclusions of the original systematic review. Although the findings of the trials identified in this update may be considered to be less affected by attrition- and publication bias, their risk of selection- and detection-/performance bias is high. Thus, verification of the currently available results requires further high quality randomised control trials.
    Keywords Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
    Subject code 610
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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