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Article ; Online: Assessment of thirty-day readmission rate, timing, causes and predictors after hospitalization with COVID-19.

Yeo, I / Baek, S / Kim, J / Elshakh, H / Voronina, A / Lou, M S / Vapnik, J / Kaler, R / Dai, X / Goldbarg, S

Journal of internal medicine

2021  Volume 290, Issue 1, Page(s) 157–165

Abstract: ... predictors and outcomes of 30-day readmission after COVID-19 hospitalization.: Methods: From 13 March to 9 ... hospitalization with coronavirus disease 2019 (COVID-19).: Objectives: To examine the rate, timing, causes ... Conclusion: With 4.5% of the thirty-day readmission rate, COVID-19 survivors were readmitted early after ...

Abstract Background: There are limited data on the characteristics of 30-day readmission after hospitalization with coronavirus disease 2019 (COVID-19).
Objectives: To examine the rate, timing, causes, predictors and outcomes of 30-day readmission after COVID-19 hospitalization.
Methods: From 13 March to 9 April 2020, all patients hospitalized with COVID-19 and discharged alive were included in this retrospective observational study. Multivariable logistic regression was used to identify the predictors of 30-day readmission, and a restricted cubic spline function was utilized to assess the linearity of the association between continuous predictors and 30-day readmission.
Results: A total of 1062 patients were included in the analysis, with a median follow-up time of 62 days. The mean age of patients was 56.5 years, and 40.5% were women. At the end of the study, a total of 48 (4.5%) patients were readmitted within 30 days of discharge, and a median time to readmission was 5 days. The most common primary diagnosis of 30-day readmission was a hypoxic respiratory failure (68.8%) followed by thromboembolism (12.5%) and sepsis (6.3%). The patients with a peak serum creatinine level of ≥1.29 mg/dL during the index hospitalization, compared to those with a creatinine of <1.29 mg/dL, had 2.4 times increased risk of 30-day readmission (adjusted odds ratio: 2.41; 95% CI: 1.23-4.74). The mortality rate during the readmission was 22.9%.
Conclusion: With 4.5% of the thirty-day readmission rate, COVID-19 survivors were readmitted early after hospital discharge, mainly due to morbidities of COVID-19. One in five readmitted COVID-19 survivors died during their readmission.
MeSH term(s) COVID-19/therapy ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Pandemics ; Patient Readmission/statistics & numerical data ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; Prognosis ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Time Factors
Language English
Publishing date 2021-02-05
Publishing country England
Document type Journal Article ; Observational Study
ZDB-ID 96274-0
ISSN 1365-2796 ; 0954-6820
ISSN (online) 1365-2796
ISSN 0954-6820
DOI 10.1111/joim.13241
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