Article ; Online: Lactobacillus fermentum CJL-112 protects mice against influenza virus infection by activating T-helper 1 and eliciting a protective immune response.
International immunopharmacology
2014 Volume 18, Issue 1, Page(s) 50–54
Abstract: ... Therefore, CJL-112 likely protects the mice against lethal IFV infection via stimulation ... efficiently improves resistance against lethal influenza infection in both mice and chicken. The aim of the present ... for 21 days prior to influenza A/NWS/33 (H1N1) virus (IFV) infection. Significant up-regulation of T ...
| Abstract | We have previously reported that nasally administered Lactobacillus fermentum CJL-112 (CJL-112) efficiently improves resistance against lethal influenza infection in both mice and chicken. The aim of the present study was to understand the underlying mechanisms of the significant anti-influenza activity of this lactobacilli strain. In vitro, co-culturing of the chicken macrophage cell line HD-11 with CJL-112 significantly increased nitric oxide (NO) production. In vivo, CJL-112 was nasally administered to BALB/c mice for 21 days prior to influenza A/NWS/33 (H1N1) virus (IFV) infection. Significant up-regulation of T-helper 1 (Th1) cytokines (IL-2, IFN-γ) was observed, while the levels of T-helper 2 (Th2) cytokines (IL-4, IL-5, IL-10) was either reduced or unchanged than that in control mice were. Furthermore, IgA and specific anti-influenza IgA levels increased significantly in the treated mice than those in untreated mice. Therefore, CJL-112 likely protects the mice against lethal IFV infection via stimulation of macrophages, activation of Th1 and augmentation of IgA production, when directly delivered into the respiratory tract. |
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| MeSH term(s) | Administration, Intranasal ; Animals ; Antibodies, Viral/metabolism ; Cell Line ; Chickens ; Coinfection ; Cytokines/metabolism ; Female ; Gram-Positive Bacterial Infections/immunology ; Immunity, Humoral ; Influenza A Virus, H1N1 Subtype/immunology ; Lactobacillus fermentum/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; Orthomyxoviridae Infections/immunology ; Th1 Cells/immunology ; Th1 Cells/microbiology ; Th1 Cells/virology | |||||
| Chemical Substances | Antibodies, Viral ; Cytokines | |||||
| Language | English | |||||
| Publishing date | 2014-01 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2043785-7 | |||||
| ISSN | 1878-1705 ; 1567-5769 | |||||
| ISSN (online) | 1878-1705 | |||||
| ISSN | 1567-5769 | |||||
| DOI | 10.1016/j.intimp.2013.10.020 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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