Article: Immunofluorescence determination of the pathogenesis of infection with influenza virus in mice following exposure to aerosolized virus.
The Journal of infectious diseases
1979 Volume 139, Issue 4, Page(s) 458–464
Abstract: The pathogenesis of infection with influenza A virus in mice was studied by exposure ... of specific pathogen-free mice to aerosols of influenza virus and by monitoring of mortality, viral titers in lung ... alveolar cells. This semiquantitative survey of the dynamics of influenza viral infection by aerosol ...
| Abstract | The pathogenesis of infection with influenza A virus in mice was studied by exposure of specific pathogen-free mice to aerosols of influenza virus and by monitoring of mortality, viral titers in lung homogenates, and presence of viral antigens in respiratory cells as determined by immunofluorescence. In two experiments with different death rates (100% and 43%), viral antigen accumulated in the epithelial cells lining the airways, in alveolar macrophages, in alveolar cells, and in visceral pleura. By enumeration of the number of airways, alveolar macrophages, and alveolar cells containing influenza viral antigens at different intervals after exposure to the viral aerosol, it was determined that viral replication occurred initially in the epithelial cells lining the airways and later extended to the alveolar macrophages and alveolar cells. This semiquantitative survey of the dynamics of influenza viral infection by aerosol indicated that the viral infection in mice was a descending process. |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MeSH term(s) | Aerosols ; Animals ; Antigens, Viral/analysis ; Fluorescent Antibody Technique ; Germ-Free Life ; Influenza A virus/immunology ; Influenza A virus/pathogenicity ; Lung/immunology ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred Strains ; Orthomyxoviridae Infections/etiology ; Orthomyxoviridae Infections/immunology ; Pulmonary Alveoli/immunology ; Rabbits ; Time Factors | ||||||||||
| Chemical Substances | Aerosols ; Antigens, Viral | ||||||||||
| Language | English | ||||||||||
| Publishing date | 1979-04 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 3019-3 | ||||||||||
| ISSN | 1537-6613 ; 0022-1899 | ||||||||||
| ISSN (online) | 1537-6613 | ||||||||||
| ISSN | 0022-1899 | ||||||||||
| DOI | 10.1093/infdis/139.4.458 | ||||||||||
| Shelf mark |
|
||||||||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Uh II Zs.50: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
|||
| Zs.MO 445: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.