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  1. Article ; Online: Hypermetabolism and Coronavirus Disease 2019.

    Yu, Pey-Jen / Cassiere, Hugh / DeRosa, Sarah / Bocchieri, Karl / Yar, Shiraz / Hartman, Alan

    JPEN. Journal of parenteral and enteral nutrition

    2020  Volume 44, Issue 7, Page(s) 1234–1236

    Abstract: ... respiratory distress syndrome, and severe burn injuries. We hypothesize that patients with Coronavirus disease ... 2019 (COVID-19) may develop a hypermetabolic state, which may be a major contributing factor ... to the extraordinary ventilatory and oxygenation demands in patients with COVID-19.: Method: Resting ...

    Abstract Background: Hypermetabolism has been described in stress states such as trauma, sepsis, acute respiratory distress syndrome, and severe burn injuries. We hypothesize that patients with Coronavirus disease 2019 (COVID-19) may develop a hypermetabolic state, which may be a major contributing factor to the extraordinary ventilatory and oxygenation demands in patients with COVID-19.
    Method: Resting energy expenditure (REE), carbon dioxide production (VCO
    Results: The median measured REE was 4044 kcal/d, which was 235.7% ± 51.7% of predicted. The median VCO
    Conclusion: Critically ill patients with COVID-19 are in an extreme hypermetabolic state. This may explain the high failure rates for mechanical ventilation for these patients and highlights the potential need for increased nutrition requirements for such patients.
    MeSH term(s) Adult ; Basal Metabolism ; COVID-19/metabolism ; COVID-19/virology ; Calorimetry, Indirect/methods ; Carbon Dioxide/metabolism ; Critical Illness ; Energy Metabolism ; Humans ; Nutritional Requirements ; Oxygen Consumption ; Respiration, Artificial ; Respiratory Distress Syndrome ; Rest ; SARS-CoV-2
    Chemical Substances Carbon Dioxide (142M471B3J)
    Keywords covid19
    Language English
    Publishing date 2020-07-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800861-9
    ISSN 1941-2444 ; 0148-6071
    ISSN (online) 1941-2444
    ISSN 0148-6071
    DOI 10.1002/jpen.1948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Hypermetabolism and Coronavirus Disease 2019

    Yu, Pey-Jen / Cassiere, Hugh / DeRosa, Sarah / Bocchieri, Karl / Yar, Shiraz / Hartman, Alan

    JPEN J. parenter. enteral nutr

    Abstract: ... respiratory distress syndrome, and severe burn injuries. We hypothesize that patients with Coronavirus disease ... 2019 (COVID-19) may develop a hypermetabolic state, which may be a major contributing factor ... to the extraordinary ventilatory and oxygenation demands in patients with COVID-19. METHOD: Resting energy expenditure ...

    Abstract BACKGROUND: Hypermetabolism has been described in stress states such as trauma, sepsis, acute respiratory distress syndrome, and severe burn injuries. We hypothesize that patients with Coronavirus disease 2019 (COVID-19) may develop a hypermetabolic state, which may be a major contributing factor to the extraordinary ventilatory and oxygenation demands in patients with COVID-19. METHOD: Resting energy expenditure (REE), carbon dioxide production (VCO2 ), and oxygen consumption (VO2 ) were measured by indirect calorimetry on 7 critically ill patients with COVID-19. RESULTS: The median measured REE was 4044 kcal/d, which was 235.7% ± 51.7% of predicted. The median VCO2 was 452 mL/min (range, 295-582 mL/min), and the median VO2 was 585 mL/min (range, 416-798 mL/min). CONCLUSION: Critically ill patients with COVID-19 are in an extreme hypermetabolic state. This may explain the high failure rates for mechanical ventilation for these patients and highlights the potential need for increased nutrition requirements for such patients.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #607575
    Database COVID19

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  3. Article ; Online: Cardiopulmonary Exercise Testing in Critically Ill Coronavirus Disease 2019 Survivors: Evidence of a Sustained Exercise Intolerance and Hypermetabolism.

    Joris, Maurice / Minguet, Pauline / Colson, Camille / Joris, Jean / Fadeur, Marjorie / Minguet, Gregory / Guiot, Julien / Misset, Benoit / Rousseau, Anne-Françoise

    Critical care explorations

    2021  Volume 3, Issue 7, Page(s) e0491

    Abstract: ... coronavirus disease 2019 pneumonia and attending our post-ICU follow-up clinic.: Measurements and main ... exercise capacity was observed up to 6 months in critically ill coronavirus disease 2019 survivors ... characterized by a sustained hypermetabolism and an impaired oxygen utilization. ...

    Abstract To investigate exercise capacity at 3 and 6 months after a prolonged ICU stay.
    Design: Observational monocentric study.
    Setting: A post-ICU follow-up clinic in a tertiary university hospital in Liège, Belgium.
    Patients: Patients surviving an ICU stay greater than or equal to 7 days for a severe coronavirus disease 2019 pneumonia and attending our post-ICU follow-up clinic.
    Measurements and main results: Cardiopulmonary and metabolic variables provided by a cardiopulmonary exercise testing on a cycle ergometer were collected at rest, at peak exercise, and during recovery. Fourteen patients (10 males, 59 yr [52-62 yr], all obese with body mass index > 27 kg/m
    Conclusions: Prolonged reduced exercise capacity was observed up to 6 months in critically ill coronavirus disease 2019 survivors. This disability did not result from residual pulmonary or cardiac dysfunction but rather from a metabolic disorder characterized by a sustained hypermetabolism and an impaired oxygen utilization.
    Language English
    Publishing date 2021-07-13
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Inferior Colliculus's Hypermetabolism: A New Finding on Brain FDG PET and Perfusion MRI in a Patient With COVID-19.

    Chammas, Agathe / Namer, Izzie Jacques / Lersy, François / Kremer, Stéphane / Bund, Caroline

    Clinical nuclear medicine

    2021  Volume 46, Issue 5, Page(s) 413–414

    Abstract: ... performed after the confusion phase, but still in the COVID-19 (coronavirus disease 2019)-positive phase ... CoV-2 (severe acute respiratory syndrome coronavirus 2) infection with a positive oropharyngeal swab ... perfusion MRI shows hyperperfusion of the inferior colliculi, corresponding to FDG PET hypermetabolism. ...

    Abstract Abstract: We present the case of a 64-year-old man presenting an episode of confusion during SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection with a positive oropharyngeal swab polymerase chain reaction test. He was hospitalized for dyspnea related to pneumonia demonstrated on chest CT. FDG PET performed after the confusion phase, but still in the COVID-19 (coronavirus disease 2019)-positive phase, showed high glucose metabolism of the inferior colliculi. Morphological MRI was normal. The first-pass perfusion MRI shows hyperperfusion of the inferior colliculi, corresponding to FDG PET hypermetabolism.
    MeSH term(s) COVID-19/diagnostic imaging ; COVID-19/metabolism ; Fluorodeoxyglucose F18 ; Humans ; Inferior Colliculi/diagnostic imaging ; Inferior Colliculi/metabolism ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Perfusion Imaging ; Positron-Emission Tomography
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hypermetabolic lymphadenopathy following the administration of COVID-19 vaccine and immunotherapy in a lung cancer patient: a case report.

    Tripathy, Shreya / Alvarez, Nathaniel / Jaiswal, Shubham / Williams, Ryan / Al-Khadimi, Munaf / Hackman, Sarah / Phillips, William / Kaur, Supreet / Cervantez, Sherri / Kelly, William / Taverna, Josephine

    Journal of medical case reports

    2022  Volume 16, Issue 1, Page(s) 445

    Abstract: ... population group, these patients are strongly advised to receive coronavirus disease 2019 vaccination in accordance ... her coronavirus disease 2019 booster vaccination. At the time, she had been receiving long-term immunotherapy ... with Center for Disease Control and Prevention guidelines to minimize morbidity and mortality. In recent years ...

    Abstract Background: Given the current climate of the pandemic, lung cancer patients are especially vulnerable to complications from severe acute respiratory syndrome coronavirus 2 infection. As a high-risk population group, these patients are strongly advised to receive coronavirus disease 2019 vaccination in accordance with Center for Disease Control and Prevention guidelines to minimize morbidity and mortality. In recent years, immunotherapy has taken a preeminent role in the treatment of non-small cell lung cancer with dramatic improvement in overall survival. Reactive lymphadenopathy following the administration of a coronavirus disease 2019 vaccination can confound the radiographic interpretation of positron emission tomography-computed tomography or computed tomography scans from lung cancer patients receiving immunotherapy.
    Case presentation: Here, we present a case of a 61-year-old Caucasian female and former smoker who developed cervical, hilar, supraclavicular, mediastinal, and left retroauricular lymphadenopathy following her coronavirus disease 2019 booster vaccination. At the time, she had been receiving long-term immunotherapy for the treatment of advanced lung adenocarcinoma. Biopsy was pursued owing to concerns of treatment failure and confirmed recurrent malignancy.
    Conclusion: This case report highlights the importance of lymph node biopsies in lung cancer patients who present with contralateral lymphadenopathy following coronavirus disease 2019 vaccination to rule out tumor recurrence in this deserving patient population.
    MeSH term(s) Female ; Humans ; Middle Aged ; Carcinoma, Non-Small-Cell Lung/therapy ; Carcinoma, Non-Small-Cell Lung/pathology ; COVID-19/therapy ; COVID-19 Vaccines/adverse effects ; Immunotherapy ; Lung Neoplasms/therapy ; Lung Neoplasms/pathology ; Lymphadenopathy/etiology ; Neoplasm Recurrence, Local
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-11-25
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-022-03660-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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