Article ; Online: Hypermetabolism and Coronavirus Disease 2019.
JPEN. Journal of parenteral and enteral nutrition
2020 Volume 44, Issue 7, Page(s) 1234–1236
Abstract: ... respiratory distress syndrome, and severe burn injuries. We hypothesize that patients with Coronavirus disease ... 2019 (COVID-19) may develop a hypermetabolic state, which may be a major contributing factor ... to the extraordinary ventilatory and oxygenation demands in patients with COVID-19.: Method: Resting ...
Abstract | Background: Hypermetabolism has been described in stress states such as trauma, sepsis, acute respiratory distress syndrome, and severe burn injuries. We hypothesize that patients with Coronavirus disease 2019 (COVID-19) may develop a hypermetabolic state, which may be a major contributing factor to the extraordinary ventilatory and oxygenation demands in patients with COVID-19. Method: Resting energy expenditure (REE), carbon dioxide production (VCO Results: The median measured REE was 4044 kcal/d, which was 235.7% ± 51.7% of predicted. The median VCO Conclusion: Critically ill patients with COVID-19 are in an extreme hypermetabolic state. This may explain the high failure rates for mechanical ventilation for these patients and highlights the potential need for increased nutrition requirements for such patients. |
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MeSH term(s) | Adult ; Basal Metabolism ; COVID-19/metabolism ; COVID-19/virology ; Calorimetry, Indirect/methods ; Carbon Dioxide/metabolism ; Critical Illness ; Energy Metabolism ; Humans ; Nutritional Requirements ; Oxygen Consumption ; Respiration, Artificial ; Respiratory Distress Syndrome ; Rest ; SARS-CoV-2 |
Chemical Substances | Carbon Dioxide (142M471B3J) |
Keywords | covid19 |
Language | English |
Publishing date | 2020-07-12 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 800861-9 |
ISSN | 1941-2444 ; 0148-6071 |
ISSN (online) | 1941-2444 |
ISSN | 0148-6071 |
DOI | 10.1002/jpen.1948 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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