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  1. Article: Is there possibility of vertical transmission of COVID-19: a systematic review.

    Yuan, Jiajun / Qian, Han / Cao, Shiyan / Dong, Bin / Yan, Xiaoyu / Luo, Shuanghong / Zhou, Min / Zhou, Sha / Ning, Botao / Zhao, Liebin

    Translational pediatrics

    2021  Volume 10, Issue 2, Page(s) 423–434

    Abstract: ... disease 2019 (COVID-19) and the evidence of vertical transmission of COVID-19, we retrieved studies ... terms, such as 'COVID-19', 'vertical transmission' ...

    Abstract In order to investigate the clinical features of pregnant women and their neonates with coronavirus disease 2019 (COVID-19) and the evidence of vertical transmission of COVID-19, we retrieved studies included in PubMed, Medline and Chinese databases from January 1, 2000 to October 25, 2020 using relevant terms, such as 'COVID-19', 'vertical transmission'
    Language English
    Publishing date 2021-03-08
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-20-144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Is SARS-CoV-2 Vertically Transmitted?

    Simões E Silva, Ana Cristina / Leal, Caio Ribeiro Vieira

    Frontiers in pediatrics

    2020  Volume 8, Page(s) 276

    Abstract: ... databases using the Medical Subject Heading terms "coronavirus," "COVID-19," and "vertical transmission ... by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed. The disease, named COVID-19, has a wide spectrum ... for adverse outcomes. The purpose of this mini-review was to investigate what is in the scientific literature ...

    Abstract At the end of 2019, in Wuhan (China), the onset of a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed. The disease, named COVID-19, has a wide spectrum of clinical presentations, ranging from asymptomatic or mild to critical, and for some patients the disease is even fatal. Apparently, being a child or being pregnant does not represent an additional risk for adverse outcomes. The purpose of this mini-review was to investigate what is in the scientific literature, so far, in regard to vertical transmission of SARS-CoV-2. Data were obtained independently by the two authors, who carried out a systematic search in the PubMed, Embase, LILACS, Cochrane, Scopus and SciELO databases using the Medical Subject Heading terms "coronavirus," "COVID-19," and "vertical transmission." Few studies about the vertical transmission of SARS-CoV-2 are found in the literature. In all case reports and case series, the mothers' infection occurred in the third trimester of pregnancy, there were no maternal deaths, and most neonates had a favorable clinical course. The virus was not detected in the neonate nasopharyngeal swab samples at birth, in the placenta, in the umbilical cord, in the amniotic fluid, in the breast milk or in the maternal vaginal swab samples in any of these articles. Only three papers reported neonatal SARS-CoV-2 infection, but there is a bias that positive pharyngeal swab samples were collected at 36 h and on the 2nd, 4th, and 17th days of life. The possibility of intrauterine infection has been based mainly on the detection of IgM and IL-6 in the neonates' serum. In conclusion, to date, no convincing evidence has been found for vertical transmission of SARS-CoV-2.
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.00276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is SARS-CoV-2 Vertically Transmitted?

    Ana Cristina Simões e Silva / Caio Ribeiro Vieira Leal

    Frontiers in Pediatrics, Vol

    2020  Volume 8

    Abstract: ... databases using the Medical Subject Heading terms “coronavirus,” “COVID-19,” and “vertical transmission ... by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed. The disease, named COVID-19, has a wide spectrum ... for adverse outcomes. The purpose of this mini-review was to investigate what is in the scientific literature ...

    Abstract At the end of 2019, in Wuhan (China), the onset of a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed. The disease, named COVID-19, has a wide spectrum of clinical presentations, ranging from asymptomatic or mild to critical, and for some patients the disease is even fatal. Apparently, being a child or being pregnant does not represent an additional risk for adverse outcomes. The purpose of this mini-review was to investigate what is in the scientific literature, so far, in regard to vertical transmission of SARS-CoV-2. Data were obtained independently by the two authors, who carried out a systematic search in the PubMed, Embase, LILACS, Cochrane, Scopus and SciELO databases using the Medical Subject Heading terms “coronavirus,” “COVID-19,” and “vertical transmission.” Few studies about the vertical transmission of SARS-CoV-2 are found in the literature. In all case reports and case series, the mothers' infection occurred in the third trimester of pregnancy, there were no maternal deaths, and most neonates had a favorable clinical course. The virus was not detected in the neonate nasopharyngeal swab samples at birth, in the placenta, in the umbilical cord, in the amniotic fluid, in the breast milk or in the maternal vaginal swab samples in any of these articles. Only three papers reported neonatal SARS-CoV-2 infection, but there is a bias that positive pharyngeal swab samples were collected at 36 h and on the 2nd, 4th, and 17th days of life. The possibility of intrauterine infection has been based mainly on the detection of IgM and IL-6 in the neonates' serum. In conclusion, to date, no convincing evidence has been found for vertical transmission of SARS-CoV-2.
    Keywords SARS-CoV-2 ; COVID-19 ; vertical transmission ; pregnant women ; neonate ; intrauterine infection ; Pediatrics ; RJ1-570 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Is SARS-CoV-2 Vertically Transmitted?

    Simões e Silva, Ana Cristina / Leal, Caio Ribeiro Vieira

    Front. Pediatr.

    Abstract: ... databases using the Medical Subject Heading terms “coronavirus,” “COVID-19,” and “vertical transmission ... by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed. The disease, named COVID-19, has a wide spectrum ... for adverse outcomes. The purpose of this mini-review was to investigate what is in the scientific literature ...

    Abstract At the end of 2019, in Wuhan (China), the onset of a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed. The disease, named COVID-19, has a wide spectrum of clinical presentations, ranging from asymptomatic or mild to critical, and for some patients the disease is even fatal. Apparently, being a child or being pregnant does not represent an additional risk for adverse outcomes. The purpose of this mini-review was to investigate what is in the scientific literature, so far, in regard to vertical transmission of SARS-CoV-2. Data were obtained independently by the two authors, who carried out a systematic search in the PubMed, Embase, LILACS, Cochrane, Scopus and SciELO databases using the Medical Subject Heading terms “coronavirus,” “COVID-19,” and “vertical transmission.” Few studies about the vertical transmission of SARS-CoV-2 are found in the literature. In all case reports and case series, the mothers' infection occurred in the third trimester of pregnancy, there were no maternal deaths, and most neonates had a favorable clinical course. The virus was not detected in the neonate nasopharyngeal swab samples at birth, in the placenta, in the umbilical cord, in the amniotic fluid, in the breast milk or in the maternal vaginal swab samples in any of these articles. Only three papers reported neonatal SARS-CoV-2 infection, but there is a bias that positive pharyngeal swab samples were collected at 36 h and on the 2nd, 4th, and 17th days of life. The possibility of intrauterine infection has been based mainly on the detection of IgM and IL-6 in the neonates' serum. In conclusion, to date, no convincing evidence has been found for vertical transmission of SARS-CoV-2.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #547965
    Database COVID19

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  5. Article ; Online: Outcome of SARS-CoV-2 in pregnancy and newborns – is there a new kid in the TORCH block?

    Andreia Florina Nita / Sabina Cornelia Manolescu / Mircea Ioan Popa / Loredana Gabriela Popa

    Romanian Journal of Infectious Diseases, Vol 24, Iss 1, Pp 5-

    2021  Volume 13

    Abstract: ... the outcomes of pregnancy in women with COVID-19 infection and their newborns while estimating the possibility ... with COVID-19 and 7 case reports of neonates with congenital transmission of COVID-19. Overall, the rate ... Vertical transmission is possible and it seems to occur in about 3% of cases. Overall maternal and perinatal outcome is ...

    Abstract Objective. This study aimed to perform a systematic review of existing literature to assess the outcomes of pregnancy in women with COVID-19 infection and their newborns while estimating the possibility of vertical transmission. Materials and methods. We conducted a systematic literature research using Pubmed and Google Scholar covering the period from December 2019 to 20th of November 2020. The review was conducted in accordance with PRISMA guidelines. Outcomes. We included 16 studies – systematic reviews and meta-analyses published between May 2020 and November 2020 – which focused on perinatal outcomes of pregnant women with COVID-19 and 7 case reports of neonates with congenital transmission of COVID-19. Overall, the rate of COVID-19 cases in neonates of COVID-19 positive mothers was 3% with 95% CI [1.86, 4.24]). The preterm birth rate was 16.4% with 95% CI [10.5, 22.3] and the rate of stillbirths and foetal deaths was 1.4% (11 studies, 0 to 4.8%). From the 7 newborns with proved vertical transmission, majority were born preterm, with good birth weight and APGAR score and heterogenous symptoms; 4 developed severe symptoms. Overall progress and evolution for both mother and newborn was good. Conclusions. COVID-19 impact on pregnancy outcome is similar to general population in regard to preterm rate and stillbirth rate. Vertical transmission is possible and it seems to occur in about 3% of cases. Overall maternal and perinatal outcome is favourable and clinical presentation of in utero transmission of SARSCoV-2 in newborns is heterogenous.
    Keywords covid-19 ; vertical transmission ; neonates ; congenital infection ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Subject code 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Amaltea Medical Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: EFFECTS OF COVID-19 INFECTION DURING PREGNANCY AND NEONATAL PROGNOSIS: WHAT IS THE EVIDENCE?

    de Sousa, Alvaro Francisco Lopes / Carvalho, Herica Emilia Felix de / Oliveira, Layze Braz de / Schneider, Guilherme / Camargo, Emerson Lucas Silva / Watanabe, Evandro / Andrade, Denise / Carvalho, Ana Fatima / Mendes, Isabel Amelia Costa / Fronteira, Ines

    Abstract: Background: Little is known about how COVID-19 infection affects pregnant women, as well ... as about the possibility of vertical transmission or that of premature labor. Thus, this studys objective was to identify ... existing evidence to directive public policies. Method: Systematic literature review assessing papers ...

    Abstract Background: Little is known about how COVID-19 infection affects pregnant women, as well as about the possibility of vertical transmission or that of premature labor. Thus, this studys objective was to identify existing evidence to directive public policies. Method: Systematic literature review assessing papers published in the most comprehensive databases in the field of health. Results: 12 papers were eligible. A total of 119 pregnant women aged between 22 and 42 years old and between the 12th and 41st weeks were analyzed; 90 children were born. Most pregnant women acquired the infection in the third trimester of pregnancy, 97.4% were diagnosed before hospitalization based on signs and symptoms. There was no maternal death and no vertical transmission was confirmed. Conclusions: pregnant women must be cautious and vigilant because their exposure to the virus, even if at the end of a pregnancy, has important repercussions, especially for the type of labor.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.04.17.20069435
    Database COVID19

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