Article ; Online: Effects of Corticosteroid Treatment for Non-Severe COVID-19 Pneumonia: A Propensity Score-Based Analysis.
2020 Volume 54, Issue 5, Page(s) 638–643
Abstract: Background and objective: The effects of corticosteroid treatment on non-severe COVID-19 pneumonia ... with non-severe COVID-19 pneumonia.: Method: A retrospective cohort study based on propensity score ... a negative effect on lung injury recovery in non-severe COVID-19 pneumonia patients; however, the results ...
| Abstract | Background and objective: The effects of corticosteroid treatment on non-severe COVID-19 pneumonia patients are unknown. To determine the impacts of adjuvant corticosteroid administrated to patients with non-severe COVID-19 pneumonia. Method: A retrospective cohort study based on propensity score analysis was designed to explore the effects of corticosteroid on several clinical outcomes. Results: One hundred thirty-two patients satisfied the inclusion criteria and 35 pairs were generated according to propensity score matching. Compared to non-corticosteroid group, the CT score on day 7 was significantly higher in corticosteroid group (8.6 (interquartile range [IQR], 2.8-11.5) versus 12.0 (IQR, 5.0-19.3), P = 0.046). In corticosteroid group, more patients progressed to severe cases (11.4% versus 2.9%, P = 0.353), hospital stay (23.5 days (IQR, 19-29 d) versus 20.2 days (IQR, 14-25.3 d), P = 0.079) and duration of viral shedding (20.3 days (IQR, 15.2-24.8 d) versus 19.4 days (IQR, 11.5-28.3 d), P = 0.669) were prolonged, while fever time (9.5 days (IQR, 6.5-12.2 d) versus 10.2 days (IQR, 6.8-14 d), P = 0.28) was shortened; however, all these data revealed no statistically significant differences. Conclusion: Corticosteroid might have a negative effect on lung injury recovery in non-severe COVID-19 pneumonia patients; however, the results of this study must be interpreted with caution because of confounding factors. |
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| MeSH term(s) | Adrenal Cortex Hormones/adverse effects ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Betacoronavirus/drug effects ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Disease Progression ; Female ; Host-Pathogen Interactions ; Humans ; Length of Stay ; Lung/diagnostic imaging ; Lung/drug effects ; Lung/virology ; Male ; Middle Aged ; Multidetector Computed Tomography ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Propensity Score ; Retrospective Studies ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Time Factors ; Treatment Outcome ; Virus Shedding |
| Chemical Substances | Adrenal Cortex Hormones |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-06-04 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1185432-7 |
| ISSN | 1540-0514 ; 1073-2322 |
| ISSN (online) | 1540-0514 |
| ISSN | 1073-2322 |
| DOI | 10.1097/SHK.0000000000001574 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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