Article: Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis.
Acta pharmaceutica Sinica. B
2020
Abstract: ... multiple sclerosis (MS). Herein, a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents ... to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and ... Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics ...
| Abstract | Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). Herein, a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents were designed and synthesized. 2-Acrylamidobenzoic acid analog |
|---|---|
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-10-15 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ISSN | 2211-3835 |
| ISSN | 2211-3835 |
| DOI | 10.1016/j.apsb.2020.10.008 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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