Article ; Online: CD4+ and CD8+ cell counts are significantly correlated with absolute lymphocyte count in hospitalized COVID-19 patients: a retrospective study.
2023 Volume 11, Page(s) e15509
Abstract: ... of this study, there is a correlation between CD4+ and CD8+ cell counts and ALC in COVID-19 patients ... cell counts and absolute lymphocyte count (ALC) in COVID-19 patients and analyze its difference based ... in COVID-19 patients. Such findings are frequently associated with substantial changes in T-cell counts ...
| Abstract | Background: Coronavirus disease 2019 (COVID-19) is a contagious respiratory illness that was declared a pandemic in March 2020. Lymphopenia is one of the specific laboratory results disturbance in COVID-19 patients. Such findings are frequently associated with substantial changes in T-cell counts, particularly CD4+ and CD8+ T-cells. This study aimed to examine the correlation between CD4+ and CD8+ cell counts and absolute lymphocyte count (ALC) in COVID-19 patients and analyze its difference based on the COVID-19 patients' severity. Methods: From March 2022 to May 2022, we conducted a retrospective cohort study using medical records and laboratory data from patients diagnosed with COVID-19 at our hospital who met the inclusion and exclusion criteria. The total sampling method was used to recruit study participants. We conducted bivariate analysis, which consisted of correlation and comparative analysis. Results: Thirty-five patients met the inclusion and exclusion criteria and were divided into two severity groups (mild-moderate and severe-critical). The findings of this study revealed a significant correlation between CD4+ cell count and ALC on admission (r = 0.69, Conclusion: According to the findings of this study, there is a correlation between CD4+ and CD8+ cell counts and ALC in COVID-19 patients. All lymphocyte subsets also showed a lower value in severe forms of the disease. |
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| MeSH term(s) | Humans ; COVID-19 ; Retrospective Studies ; CD8-Positive T-Lymphocytes ; Lymphocyte Count ; CD4-Positive T-Lymphocytes |
| Language | English |
| Publishing date | 2023-06-23 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2703241-3 |
| ISSN | 2167-8359 ; 2167-8359 |
| ISSN (online) | 2167-8359 |
| ISSN | 2167-8359 |
| DOI | 10.7717/peerj.15509 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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