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  1. Article ; Online: Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: a case control study.

    Zhang, Hua / Du, Feng / Cao, Xiao-Jun / Feng, Xia-Long / Zhang, He-Ping / Wu, Zheng-Xia / Wang, Bao-Feng / Zhang, Hong-Juan / Liu, Rui / Yang, Jian-Jun / Ning, Bo / Chen, Kai / Huang, Zhen-Peng

    BMC infectious diseases

    2021  Volume 21, Issue 1, Page(s) 207

    Abstract: Background: A large-scale global outbreak of coronavirus disease-19 (COVID-19) out of Wuhan ... patients out of Wuhan, from China.: Methods: Thirteen patients were confirmed to be infected with novel ... from China, occurred in January 2020. To examine the clinical characteristics of COVID-19 in infected ...

    Abstract Background: A large-scale global outbreak of coronavirus disease-19 (COVID-19) out of Wuhan, from China, occurred in January 2020. To examine the clinical characteristics of COVID-19 in infected patients out of Wuhan, from China.
    Methods: Thirteen patients were confirmed to be infected with novel coronavirus-2019 (2019-nCoV) between January 27 and February 8, 2020, in Baoji city, Shannxi, northwestern China. Epidemiological and clinical information, and computed to morphology imaging data from all COVID-19 patients were collected; cases were divided into two groups according to the severity of infection (mild or severe).
    Results: Nine (9/13) COVID-19 patients exhibited mild disease severity, and defined as second-generation human-to-human transmission cases. Most patients (11/13) had a history of travel to or from Wuhan. There were no differences in sex and age between the mild and severe cases (all P > 0.05). A moderate degree of fever (11/13), cough (13/13), and fatigue (8/13) were common symptoms; however, there was no statistical difference between mild and severe cases in this regard (all P > 0.05). Oxyhemoglobin saturation and oxygenation index decreased, and C-reactive protein (CRP) and serum amyloid A (SAA) levels were elevated in all patients with COVID-19 infection, with statistically significant differences between those with severe disease and mild infection (all P < 0.05). Twelve of 13 COVID-19 patients exhibited changes in chest CT imaging features, and time course changes were different between mild and severe cases (all P < 0.05).
    Conclusion: Most cases of COVID-19 infection were second-generation human-to-human transmissions from Wuhan and were mild in severity. The clinical characteristics of COVID-19 varied. Oxyhemoglobin saturation, oxygenation index, CRP and SAA levels, and CT features were reliable parameters to evaluate the severity of COVID-19 infection. However, a few patients with mild COVID-19 disease lacked typical characteristics such as fever and changes in CT imaging features.
    MeSH term(s) Adult ; Aged ; C-Reactive Protein/analysis ; COVID-19/blood ; COVID-19/complications ; COVID-19/epidemiology ; Case-Control Studies ; China/epidemiology ; Female ; Humans ; Male ; Middle Aged ; SARS-CoV-2 ; Serum Amyloid A Protein/analysis ; Tomography, X-Ray Computed
    Chemical Substances Serum Amyloid A Protein ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-021-05897-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A case series describing the epidemiology and clinical characteristics of COVID-19 infection in Jilin Province.

    Du, Na / Chen, Haiying / Zhang, Qing / Che, Lihe / Lou, Lixin / Li, Xiaohua / Zhang, Kaiyu / Bao, Wanguo

    Virulence

    2020  Volume 11, Issue 1, Page(s) 482–485

    Abstract: Since its outbreak in Wuhan, Hubei Province China, 2019-coronavirus infected disease (COVID-19) had ... of its epidemiology and clinical characteristics. We included 12 confirmed cases of COVID-19 in First Affiliated ... sore throat (4/12), headache (3/12), and diarrhea (2/12). Only three out of eight patients had pneumonia ...

    Abstract Since its outbreak in Wuhan, Hubei Province China, 2019-coronavirus infected disease (COVID-19) had been widely spread all over the world, the control of which calls for a better understanding of its epidemiology and clinical characteristics. We included 12 confirmed cases of COVID-19 in First Affiliated Hospital of Jilin University from 23 January 2020 to 11 February 2020, which were retrospectively analyzed for epidemiological, demographic, clinical, laboratory, and radiological features. All the patients were confirmed by nucleic acid detection, the average age of whom was 45.25 years (range, 23-79 years). Most patients had a history of Wuhan traveling or had contact with Wuhan travelers or infected cases. Obvious family cluster was observed. Clinical manifestations included fever (12/12), fatigue (10/12), cough (6/12), sore throat (4/12), headache (3/12), and diarrhea (2/12). Only three out of eight patients had pneumonia manifestation on radiography. Most patients had a normal white blood cell (WBC) count and normal or reduced lymphocyte (LY) count. Pneumonia changes were observed in all the four patients who underwent a chest CT scan. Only one elderly patient developed severe pneumonia, while all the rest were mild disease and had a self-limiting course.
    MeSH term(s) Adult ; Aged ; Betacoronavirus/isolation & purification ; COVID-19 ; China/epidemiology ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/epidemiology ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Cough/etiology ; Diarrhea/etiology ; Fatigue/etiology ; Female ; Fever/etiology ; Headache/etiology ; Humans ; Leukocyte Count ; Male ; Middle Aged ; Pandemics ; Pharyngitis/etiology ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Retrospective Studies ; SARS-CoV-2 ; Tomography, X-Ray Computed ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2020.1767357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical characteristics of 199 discharged patients with COVID-19 in Fujian Province

    Wang, Sijiao / Chen, Zhisheng / Lin, Yijian / Lin, Li / Lin, Qunying / Fang, Sufang / Shi, Yonghong / Zhuang, Xibin / Ye, Yuming / Wang, Ting / Zhang, Hongying / Shao, Changzhou

    PLOS ONE

    A multicenter retrospective study between January 22nd and February 27th, 2020

    2020  Volume 15, Issue 11, Page(s) e0242307

    Abstract: ... to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China. Methods ... Background Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and ... the world since first broke out in Wuhan, China. The outbreak that started from January 22, 2020, in Fujian ...

    Abstract Background Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and the world since first broke out in Wuhan, China. The outbreak that started from January 22, 2020, in Fujian Province has been controlled as the number of indigenous cases has not increased since March. We aimed to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China. Methods In this retrospective, multicenter study, we collected and analyzed the epidemiological, clinical, and laboratory data of all cases confirmed by nucleic acid tests in five designated hospitals in Fujian Province between January 22 and February 27, 2020. All patients were followed up until discharge. COVID-19 severity was classified as mild, moderate, severe, or critical. Results Of 199 discharged patients with COVID-19, 105 patients were male, with a median age of 46.3 years, and 17 patients were severe, and 5 patients were critical on admission. Hypertension and diabetes were the most common comorbidities. The symptoms at illness onset were mainly fever (76.4%), cough (60.8%), and myalgia or fatigue (27.6%). A total of 96.5% of patients had abnormal imaging findings on chest computed tomography. Lymphopenia (37.2%) and hypoxemia (13.6%) were observed. Acute respiratory distress syndrome and respiratory failure occurred in 9 patients (4.5%) and 8 patients (4.0%) respectively. One patient died and the others were cured and discharged with the median hospital stay of 19 days. Old age was negatively correlated with lymphocyte count (r = - 0.296, p < 0.001) and oxygenation index (r = - 0.263, p = 0.001). Bivariate regression analysis revealed that old age (≥ 75 years), hypertension, diabetes, and lymphopenia were correlated with the severity of COVID-19. Conclusions Patients in Fujian Province were mostly nonsevere cases with mild or moderate symptoms, and had a lower mortality than patients in Wuhan (4.3%-15%). Older age, hypertension, diabetes, and lymphopenia were risk factors for severity of COVID-19.
    Keywords General Biochemistry, Genetics and Molecular Biology ; General Agricultural and Biological Sciences ; General Medicine ; covid19
    Language English
    Publisher Public Library of Science (PLoS)
    Publishing country us
    Document type Article ; Online
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0242307
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article ; Online: Clinical characteristics of 199 discharged patients with COVID-19 in Fujian Province

    Sijiao Wang / Zhisheng Chen / Yijian Lin / Li Lin / Qunying Lin / Sufang Fang / Yonghong Shi / Xibin Zhuang / Yuming Ye / Ting Wang / Hongying Zhang / Changzhou Shao

    PLoS ONE, Vol 15, Iss 11, p e

    A multicenter retrospective study between January 22nd and February 27th, 2020.

    2020  Volume 0242307

    Abstract: ... to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China. Methods ... Background Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and ... the world since first broke out in Wuhan, China. The outbreak that started from January 22, 2020, in Fujian ...

    Abstract Background Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and the world since first broke out in Wuhan, China. The outbreak that started from January 22, 2020, in Fujian Province has been controlled as the number of indigenous cases has not increased since March. We aimed to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China. Methods In this retrospective, multicenter study, we collected and analyzed the epidemiological, clinical, and laboratory data of all cases confirmed by nucleic acid tests in five designated hospitals in Fujian Province between January 22 and February 27, 2020. All patients were followed up until discharge. COVID-19 severity was classified as mild, moderate, severe, or critical. Results Of 199 discharged patients with COVID-19, 105 patients were male, with a median age of 46.3 years, and 17 patients were severe, and 5 patients were critical on admission. Hypertension and diabetes were the most common comorbidities. The symptoms at illness onset were mainly fever (76.4%), cough (60.8%), and myalgia or fatigue (27.6%). A total of 96.5% of patients had abnormal imaging findings on chest computed tomography. Lymphopenia (37.2%) and hypoxemia (13.6%) were observed. Acute respiratory distress syndrome and respiratory failure occurred in 9 patients (4.5%) and 8 patients (4.0%) respectively. One patient died and the others were cured and discharged with the median hospital stay of 19 days. Old age was negatively correlated with lymphocyte count (r = - 0.296, p < 0.001) and oxygenation index (r = - 0.263, p = 0.001). Bivariate regression analysis revealed that old age (≥ 75 years), hypertension, diabetes, and lymphopenia were correlated with the severity of COVID-19. Conclusions Patients in Fujian Province were mostly nonsevere cases with mild or moderate symptoms, and had a lower mortality than patients in Wuhan (4.3%-15%). Older age, hypertension, diabetes, and lymphopenia were risk factors for severity of COVID-19.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Clinical characteristics of 199 discharged patients with COVID-19 in Fujian Province: A multicenter retrospective study between January 22nd and February 27th, 2020.

    Wang, Sijiao / Chen, Zhisheng / Lin, Yijian / Lin, Li / Lin, Qunying / Fang, Sufang / Shi, Yonghong / Zhuang, Xibin / Ye, Yuming / Wang, Ting / Zhang, Hongying / Shao, Changzhou

    PloS one

    2020  Volume 15, Issue 11, Page(s) e0242307

    Abstract: ... to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China.: Methods ... Background: Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and ... with the severity of COVID-19.: Conclusions: Patients in Fujian Province were mostly nonsevere cases with mild or ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and the world since first broke out in Wuhan, China. The outbreak that started from January 22, 2020, in Fujian Province has been controlled as the number of indigenous cases has not increased since March. We aimed to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China.
    Methods: In this retrospective, multicenter study, we collected and analyzed the epidemiological, clinical, and laboratory data of all cases confirmed by nucleic acid tests in five designated hospitals in Fujian Province between January 22 and February 27, 2020. All patients were followed up until discharge. COVID-19 severity was classified as mild, moderate, severe, or critical.
    Results: Of 199 discharged patients with COVID-19, 105 patients were male, with a median age of 46.3 years, and 17 patients were severe, and 5 patients were critical on admission. Hypertension and diabetes were the most common comorbidities. The symptoms at illness onset were mainly fever (76.4%), cough (60.8%), and myalgia or fatigue (27.6%). A total of 96.5% of patients had abnormal imaging findings on chest computed tomography. Lymphopenia (37.2%) and hypoxemia (13.6%) were observed. Acute respiratory distress syndrome and respiratory failure occurred in 9 patients (4.5%) and 8 patients (4.0%) respectively. One patient died and the others were cured and discharged with the median hospital stay of 19 days. Old age was negatively correlated with lymphocyte count (r = - 0.296, p < 0.001) and oxygenation index (r = - 0.263, p = 0.001). Bivariate regression analysis revealed that old age (≥ 75 years), hypertension, diabetes, and lymphopenia were correlated with the severity of COVID-19.
    Conclusions: Patients in Fujian Province were mostly nonsevere cases with mild or moderate symptoms, and had a lower mortality than patients in Wuhan (4.3%-15%). Older age, hypertension, diabetes, and lymphopenia were risk factors for severity of COVID-19.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; China/epidemiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Coronavirus Infections/pathology ; Diabetes Mellitus/epidemiology ; Female ; Humans ; Hypertension/epidemiology ; Lymphopenia/epidemiology ; Male ; Middle Aged ; Pandemics ; Patient Discharge ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/pathology ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-11-12
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0242307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Clinical characteristics of coronavirus disease 2019 (COVID-19) patients with hypertension on renin-angiotensin system inhibitors

    Zhou, Xian / Zhu, Jingkang / Xu, Tao

    Clin Exp Hypertens

    Abstract: ... study, we recruited 110 discharged patients with COVID-19 at Wuhan Fourth Hospital in Wuhan, China ... In December 2019, COVID-19 outbroke in Wuhan, China. The current study aimed to explore ... and the crude mortality rate [2/15 (13.3%) vs 5/21 (23.8%)]. In conclusions, the COVID-19 patients ...

    Abstract In December 2019, COVID-19 outbroke in Wuhan, China. The current study aimed to explore the clinical characteristics of COVID-19 complicated by hypertension. In this retrospective, single-center study, we recruited 110 discharged patients with COVID-19 at Wuhan Fourth Hospital in Wuhan, China, from January 25 to February 20, 2020. All study cases were grouped according to whether they had a history of hypertension. Then, a subgroup analysis for all hypertensive patients was carried out based on whether to take ACEI or ARB drugs. The mean age of 110 patients was 57.7 years (range, 25-86 years), of which 60 (54.5%) were male patients. The main underlying diseases included hypertension [36 (32.7%)] and diabetes [11 (10.0%)]. Compared with the non-hypertensive group, the lymphocyte count was significantly lower in the hypertensive group (average value, 0.96 × 109/L vs 1.26 × 109/L), and analysis of clinical outcomes showed that the crude mortality rate was higher in the hypertensive group [7/36 (19.4%) vs 2/74 (2.7%)]. Patients treated with ACEI or ARB, compared with the control group, were younger (average age, 58.5 years vs 69.2 years), but there was no statistical difference in the crude cure rate [10/15 (66.7%) vs 15/21 (71.4%)] and the crude mortality rate [2/15 (13.3%) vs 5/21 (23.8%)]. In conclusions, the COVID-19 patients with a history of hypertension had a significantly lower lymphocyte count on admission. The elderly and comorbidities such as hypertension may together constitute risk factors for poor prognosis in patients with COVID-19. Taking ACEI or ARB drugs may not change the prognosis of COVID-19 patients with hypertension.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #260541
    Database COVID19

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  7. Article: Clinical characteristics of 199 discharged patients with COVID-19 in Fujian Province: A multicenter retrospective study between January 22nd and February 27th, 2020

    Wang, Sijiao / Chen, Zhisheng / Lin, Yijian / Lin, Li / Lin, Qunying / Fang, Sufang / Shi, Yonghong / Zhuang, Xibin / Ye, Yuming / Wang, Ting / Zhang, Hongying / Shao, Changzhou

    PLoS One

    Abstract: ... to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China. METHODS ... BACKGROUND: Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and ... the world since first broke out in Wuhan, China. The outbreak that started from January 22, 2020, in Fujian ...

    Abstract BACKGROUND: Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and the world since first broke out in Wuhan, China. The outbreak that started from January 22, 2020, in Fujian Province has been controlled as the number of indigenous cases has not increased since March. We aimed to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China. METHODS: In this retrospective, multicenter study, we collected and analyzed the epidemiological, clinical, and laboratory data of all cases confirmed by nucleic acid tests in five designated hospitals in Fujian Province between January 22 and February 27, 2020. All patients were followed up until discharge. COVID-19 severity was classified as mild, moderate, severe, or critical. RESULTS: Of 199 discharged patients with COVID-19, 105 patients were male, with a median age of 46.3 years, and 17 patients were severe, and 5 patients were critical on admission. Hypertension and diabetes were the most common comorbidities. The symptoms at illness onset were mainly fever (76.4%), cough (60.8%), and myalgia or fatigue (27.6%). A total of 96.5% of patients had abnormal imaging findings on chest computed tomography. Lymphopenia (37.2%) and hypoxemia (13.6%) were observed. Acute respiratory distress syndrome and respiratory failure occurred in 9 patients (4.5%) and 8 patients (4.0%) respectively. One patient died and the others were cured and discharged with the median hospital stay of 19 days. Old age was negatively correlated with lymphocyte count (r = - 0.296, p < 0.001) and oxygenation index (r = - 0.263, p = 0.001). Bivariate regression analysis revealed that old age (≥ 75 years), hypertension, diabetes, and lymphopenia were correlated with the severity of COVID-19. CONCLUSIONS: Patients in Fujian Province were mostly nonsevere cases with mild or moderate symptoms, and had a lower mortality than patients in Wuhan (4.3%-15%). Older age, hypertension, diabetes, and lymphopenia were risk factors for severity of COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #922715
    Database COVID19

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