Article ; Online: SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.
2017 Volume 6
Abstract: ... that a novel posttranslational mechanism, reversible lysine fatty acylation, regulates R-Ras2, a member ... of the Ras family. SIRT6, a sirtuin with established tumor suppressor function, regulates the lysine fatty ... acylation of R-Ras2. In mouse embryonic fibroblasts (MEFs), ...
| Abstract | The Ras family of GTPases are important in cell signaling and frequently mutated in human tumors. Understanding their regulation is thus important for studying biology and human diseases. Here, we report that a novel posttranslational mechanism, reversible lysine fatty acylation, regulates R-Ras2, a member of the Ras family. SIRT6, a sirtuin with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2. In mouse embryonic fibroblasts (MEFs), |
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| MeSH term(s) | Acylation ; Animals ; Fibroblasts/metabolism ; Lysine/metabolism ; Mice ; Mice, Knockout ; Protein Processing, Post-Translational ; Sirtuins/metabolism ; ras Proteins/metabolism |
| Chemical Substances | Sirt6 protein, mouse (EC 2.4.2.31) ; Sirtuins (EC 3.5.1.-) ; Rras protein, mouse (EC 3.6.1.-) ; ras Proteins (EC 3.6.5.2) ; Lysine (K3Z4F929H6) |
| Language | English |
| Publishing date | 2017-04-13 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2687154-3 |
| ISSN | 2050-084X ; 2050-084X |
| ISSN (online) | 2050-084X |
| ISSN | 2050-084X |
| DOI | 10.7554/eLife.25158 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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