Article ; Online: Identification of COVID-19 Infection-Related Human Genes Based on a Random Walk Model in a Virus-Human Protein Interaction Network.
2020 Volume 2020, Page(s) 4256301
Abstract: ... the potential pathological mechanisms of COVID-19 on a virus-human protein interaction network, and ... in the prevention and treatment of infectious diseases. In this study, we proposed a random walk model to identify ... for COVID-19 infection and for similar SARS infections, which help further developing drugs and targeted ...
| Abstract | Coronaviruses are specific crown-shaped viruses that were first identified in the 1960s, and three typical examples of the most recent coronavirus disease outbreaks include severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19. Particularly, COVID-19 is currently causing a worldwide pandemic, threatening the health of human beings globally. The identification of viral pathogenic mechanisms is important for further developing effective drugs and targeted clinical treatment methods. The delayed revelation of viral infectious mechanisms is currently one of the technical obstacles in the prevention and treatment of infectious diseases. In this study, we proposed a random walk model to identify the potential pathological mechanisms of COVID-19 on a virus-human protein interaction network, and we effectively identified a group of proteins that have already been determined to be potentially important for COVID-19 infection and for similar SARS infections, which help further developing drugs and targeted therapeutic methods against COVID-19. Moreover, we constructed a standard computational workflow for predicting the pathological biomarkers and related pharmacological targets of infectious diseases. |
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| MeSH term(s) | Betacoronavirus/isolation & purification ; Biomarkers/analysis ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/genetics ; Coronavirus Infections/virology ; Humans ; Models, Genetic ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/genetics ; Pneumonia, Viral/virology ; Protein Interaction Maps ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/diagnosis ; Severe Acute Respiratory Syndrome/genetics ; Severe Acute Respiratory Syndrome/virology |
| Chemical Substances | Biomarkers |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-07-08 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2698540-8 |
| ISSN | 2314-6141 ; 2314-6133 |
| ISSN (online) | 2314-6141 |
| ISSN | 2314-6133 |
| DOI | 10.1155/2020/4256301 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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