Article ; Online: Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.
Science immunology
2021 Volume 6, Issue 56
Abstract: ... By tracking T cell clones across tissues, we identified clonally expanded tissue-resident memory-like Th17 ... ARDS) with high mortality in patients with severe coronavirus disease 2019 (COVID-19). To understand ... immune response. We profiled immune cells in bronchoalveolar lavage fluid and blood collected from COVID-19 ...
| Abstract | Hyperinflammation contributes to lung injury and subsequent acute respiratory distress syndrome (ARDS) with high mortality in patients with severe coronavirus disease 2019 (COVID-19). To understand the underlying mechanisms involved in lung pathology, we investigated the role of the lung-specific immune response. We profiled immune cells in bronchoalveolar lavage fluid and blood collected from COVID-19 patients with severe disease and bacterial pneumonia patients not associated with viral infection. By tracking T cell clones across tissues, we identified clonally expanded tissue-resident memory-like Th17 cells (Trm17 cells) in the lungs even after viral clearance. These Trm17 cells were characterized by a a potentially pathogenic cytokine expression profile of |
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| MeSH term(s) | Bronchoalveolar Lavage Fluid/cytology ; Bronchoalveolar Lavage Fluid/immunology ; COVID-19/complications ; COVID-19/immunology ; COVID-19/pathology ; Clone Cells ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Humans ; Immunologic Memory ; Inflammation/etiology ; Inflammation/immunology ; Lung/immunology ; Lung/pathology ; Myeloid Cells ; Pneumonia, Bacterial/immunology ; Th17 Cells/immunology ; Th17 Cells/metabolism |
| Chemical Substances | Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) |
| Language | English |
| Publishing date | 2021-02-20 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 2470-9468 |
| ISSN (online) | 2470-9468 |
| DOI | 10.1126/sciimmunol.abf6692 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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