Article ; Online: TRPM7 Regulates AKT/FOXO1-Dependent Tumor Growth and Is an Independent Prognostic Indicator in Renal Cell Carcinoma.
Molecular cancer research : MCR
2018 Volume 16, Issue 6, Page(s) 1013–1023
Abstract: ... in clear cell renal cell carcinoma (ccRCC). The expression dynamics of TRPM7 was examined in a clinical cohort of RCC specimens ... Transient receptor potential melastatin 7 (TRPM7) is important for the tumorigenesis and ... progression of several cancers. However, little is known about TRPM7 expression and its clinical significance ...
| Abstract | Transient receptor potential melastatin 7 (TRPM7) is important for the tumorigenesis and progression of several cancers. However, little is known about TRPM7 expression and its clinical significance in clear cell renal cell carcinoma (ccRCC). The expression dynamics of TRPM7 was examined in a clinical cohort of RCC specimens by qPCR, immunoblotting, and IHC staining. A series of |
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| MeSH term(s) | Animals ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; Cell Proliferation/physiology ; Forkhead Box Protein O1/genetics ; Forkhead Box Protein O1/metabolism ; Heterografts ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Male ; Mice ; Mice, SCID ; Middle Aged ; Prognosis ; Protein-Serine-Threonine Kinases/biosynthesis ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; TRPM Cation Channels/biosynthesis ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism | |||||
| Chemical Substances | FOXO1 protein, human ; Forkhead Box Protein O1 ; TRPM Cation Channels ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TRPM7 protein, human (EC 2.7.11.1) | |||||
| Language | English | |||||
| Publishing date | 2018-03-15 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 2098788-2 | |||||
| ISSN | 1557-3125 ; 1541-7786 | |||||
| ISSN (online) | 1557-3125 | |||||
| ISSN | 1541-7786 | |||||
| DOI | 10.1158/1541-7786.MCR-17-0767 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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