Article: TRPM channels in the vasculature.
Advances in experimental medicine and biology
2011 Volume 704, Page(s) 707–729
Abstract: Recent studies show that mammalian melastatin TRPM nonselective cation channels (TRPM1-8), members ... vascular smooth muscles. When activated, these channels similarly to other TRPs permit the entry of sodium, calcium and ... voltage-gated Ca(2+) channels the predominant functional effect is an increase in intracellular Ca(2+ ...
| Abstract | Recent studies show that mammalian melastatin TRPM nonselective cation channels (TRPM1-8), members of the largest and most diverse TRP subfamily, are widely expressed in the endothelium and vascular smooth muscles. When activated, these channels similarly to other TRPs permit the entry of sodium, calcium and magnesium, thus causing membrane depolarisation. Although membrane depolarisation reduces the driving force for calcium entry via TRPMs as well as other pathways for calcium entry, in smooth muscle myocytes expressing voltage-gated Ca(2+) channels the predominant functional effect is an increase in intracellular Ca(2+) concentration and myocyte contraction. This review focuses on several best documented aspects of vascular functions of TRPMs, including the role of TRPM2 in oxidant stress, regulation of endothelial permeability and cell death, the connection between TRPM4 and myogenic response, significance of TRPM7 for magnesium homeostasis, vessel injury and hypertension, and emerging evidence that the cold and menthol receptor TRPM8 is involved in the regulation of vascular tone. |
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| MeSH term(s) | Blood Vessels/metabolism ; Calcium Channels/metabolism ; Humans ; Ion Channel Gating ; Oxidative Stress ; TRPM Cation Channels/metabolism |
| Chemical Substances | Calcium Channels ; TRPM Cation Channels |
| Language | English |
| Publishing date | 2011-02-03 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review |
| ISSN | 2214-8019 ; 0065-2598 |
| ISSN (online) | 2214-8019 |
| ISSN | 0065-2598 |
| DOI | 10.1007/978-94-007-0265-3_37 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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