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  1. Article: Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1.

    Zhu, Donghui / You, Jing / Zhao, Nan / Xu, Huaxi

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2019  Volume 6, Issue 18, Page(s) 1901166

    Abstract: ... ...

    Abstract Mg
    Language English
    Publishing date 2019-07-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.201901166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1

    Donghui Zhu / Jing You / Nan Zhao / Huaxi Xu

    Advanced Science, Vol 6, Iss 18, Pp n/a-n/a (2019)

    2019  

    Abstract: ... that extracellular Mg2+ enters endothelium mainly through the TRPM7 channel and MagT1 transporter. Mg2+ can act ... growth, adhesion, and migration. Endothelial barrier integrity is significantly enhanced with Mg2+ ... Moreover, Mg2+‐deficiency enhances endothelial barrier permeability in mice, and Mg2+‐treatment rescues ...

    Abstract Abstract Mg2+‐deficiency is linked to hypertension, Alzheimer's disease, stroke, migraine headaches, cardiovascular diseases, and diabetes, etc., but its exact role in these pathophysiological conditions remains elusive. Mg2+ can regulate vascular functions, yet the mechanistic insight remains ill‐defined. Data show that extracellular Mg2+ enters endothelium mainly through the TRPM7 channel and MagT1 transporter. Mg2+ can act as an antagonist to reduce Ca2+ signaling in endothelium. Mg2+ also reduces the intracellular reactive oxygen species (ROS) level and inflammation. In addition, Mg2+‐signaling increases endothelial survival and growth, adhesion, and migration. Endothelial barrier integrity is significantly enhanced with Mg2+‐treatment through S1P1‐Rac1 pathways and barrier‐stabilizing mediators including cAMP, FGF1/2, and eNOS. Mg2+ also promotes cytoskeletal reorganization and junction proteins to tighten up the barrier. Moreover, Mg2+‐deficiency enhances endothelial barrier permeability in mice, and Mg2+‐treatment rescues histamine‐induced transient vessel hyper‐permeability in vivo. In summary, Mg2+‐deficiency can cause deleterious effects in endothelium integrity, and Mg2+‐treatment may be effective in the prevention or treatment of vascular dysfunction.
    Keywords endothelial dysfunction ; Mg‐deficiency ; vascular biology ; vascular endothelium ; vascular permeability ; Science ; Q
    Subject code 572
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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