Article ; Online: Baicalin inhibits autophagy induced by influenza A virus H3N2.
2015 Volume 113, Page(s) 62–70
Abstract: ... In this study, we found that baicalin inhibited autophagy induced by influenza virus A3/Beijing/30/95 (H3N2 ... Thus, the inhibition of autophagy induced by virus may account for the antiviral activities of baicalin against H3N2 ... in both A549 and Ana-1 cells. The results showed that H3N2 induced autophagy by suppressing mTOR ...
| Abstract | Baicalin, a natural product isolated from Scutellariaradix, has been reported to have significant in vivo and in vitro anti-influenza virus activity, but the underlying mechanism remains poorly understood. In this study, we found that baicalin inhibited autophagy induced by influenza virus A3/Beijing/30/95 (H3N2) in both A549 and Ana-1 cells. The results showed that H3N2 induced autophagy by suppressing mTOR signaling pathway, which however could be significantly inhibited by baicalin. Baicalin could suppress the expression of Atg5-Atg12 complex and LC3-II, and attenuate autophagy induced by starvation. Thus, the inhibition of autophagy induced by virus may account for the antiviral activities of baicalin against H3N2. Autophagy may be a potential marker in developing novel anti-influenza drugs. |
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| MeSH term(s) | Animals ; Antiviral Agents/pharmacology ; Autophagy/drug effects ; Cell Line ; Cell Line, Tumor ; Dogs ; Flavonoids/pharmacology ; Flavonoids/toxicity ; Humans ; Influenza A Virus, H3N2 Subtype/physiology ; Macrophages/virology ; Madin Darby Canine Kidney Cells ; Mice ; Real-Time Polymerase Chain Reaction ; Scutellaria ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/metabolism | |||||
| Chemical Substances | Antiviral Agents ; Flavonoids ; baicalin (347Q89U4M5) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) | |||||
| Language | English | |||||
| Publishing date | 2015-01 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 306628-9 | |||||
| ISSN | 1872-9096 ; 0166-3542 | |||||
| ISSN (online) | 1872-9096 | |||||
| ISSN | 0166-3542 | |||||
| DOI | 10.1016/j.antiviral.2014.11.003 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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