Article ; Online: Characteristics and outcomes of hospitalised adults with COVID-19 in a Global Health Research Network: a cohort study.
2021 Volume 11, Issue 8, Page(s) e051588
Abstract: ... clinical outcomes of adult patients hospitalised with COVID-19.: Design: A cohort study using ... of characteristics and outcomes of hospitalised adult COVID-19 patients in both USA and ex-USA. It also described ... patients hospitalised with COVID-19 from the USA; 7306 from Europe, Latin America and Asia-Pacific between ...
| Abstract | Objective: To examine age, gender, and temporal differences in baseline characteristics and clinical outcomes of adult patients hospitalised with COVID-19. Design: A cohort study using deidentified electronic medical records from a Global Research Network. Setting/participants: 67 456 adult patients hospitalised with COVID-19 from the USA; 7306 from Europe, Latin America and Asia-Pacific between February 2020 and January 2021. Results: In the US cohort, compared with patients 18-34 years old, patients ≥65 had a greater risk of intensive care unit (ICU) admission (adjusted HR (aHR) 1.73, 95% CI 1.58 to 1.90), acute respiratory distress syndrome(ARDS)/respiratory failure (aHR 1.86, 95% CI 1.76 to 1.96), invasive mechanical ventilation (IMV, aHR 1.93, 95% CI, 1.73 to 2.15), and all-cause mortality (aHR 5.6, 95% CI 4.36 to 7.18). Men appeared to be at a greater risk for ICU admission (aHR 1.34, 95% CI 1.29 to 1.39), ARDS/respiratory failure (aHR 1.24, 95% CI1.21 to 1.27), IMV (aHR 1.38, 95% CI 1.32 to 1.45), and all-cause mortality (aHR 1.16, 95% CI 1.08 to 1.24) compared with women. Moreover, we observed a greater risk of adverse outcomes during the early pandemic (ie, February-April 2020) compared with later periods. In the ex-US cohort, the age and gender trends were similar; for the temporal trend, the highest proportion of patients with all-cause mortality were also in February-April 2020; however, the highest percentages of patients with IMV and ARDS/respiratory failure were in August-October 2020 followed by February-April 2020. Conclusions: This study provided valuable information on the temporal trends of characteristics and outcomes of hospitalised adult COVID-19 patients in both USA and ex-USA. It also described the population at a potentially greater risk for worse clinical outcomes by identifying the age and gender differences. Together, the information could inform the prevention and treatment strategies of COVID-19. Furthermore, it can be used to raise public awareness of COVID-19's impact on vulnerable populations. |
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| MeSH term(s) | Adolescent ; Adult ; COVID-19 ; Cohort Studies ; Female ; Global Health ; Hospitalization ; Humans ; Intensive Care Units ; Male ; Pandemics ; Respiration, Artificial ; SARS-CoV-2 ; Young Adult |
| Language | English |
| Publishing date | 2021-08-06 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2599832-8 |
| ISSN | 2044-6055 ; 2044-6055 |
| ISSN (online) | 2044-6055 |
| ISSN | 2044-6055 |
| DOI | 10.1136/bmjopen-2021-051588 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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