Article: Parvovirus B19-triggered Acute Hemolytic Anemia and Thrombocytopenia in a Child with Evans Syndrome.
Mediterranean journal of hematology and infectious diseases
2018 Volume 10, Issue 1, Page(s) e2018018
Abstract: ... standing Evans syndrome, who presented with severe anemia, reticulocytopenia and thrombocytopenia ... while serological studies and real-time PCR of whole blood were positive for acute parvovirus B19 infection ... in patients with immunologic diseases, who present reticulocytopenic hemolytic anemia and thrombocytopenia ...
| Abstract | Background: Human parvovirus B19 (HPV-B19) is the etiologic agent of erythema infectiosum, of transient aplastic crises in individuals with underlying chronic hemolytic disorders, and of chronic pure red cell aplasia in immunocompromised individuals. Case report: We describe a 14-year-old girl with long-standing Evans syndrome, who presented with severe anemia, reticulocytopenia and thrombocytopenia. A bone marrow aspirate revealed severe erythroid hypoplasia along with the presence of giant pronormoblasts, while serological studies and real-time PCR of whole blood were positive for acute parvovirus B19 infection. The patient was initially managed with corticosteroids, but both cytopenias resolved only after administration of intravenous gamma globulin 0.8g/kg. Conclusion: Acute parvovirus B19 infection should be suspected in patients with immunologic diseases, who present reticulocytopenic hemolytic anemia and thrombocytopenia. In this setting, intravenous gamma globulin is effective for both cytopenias. |
|---|---|
| Language | English |
| Publishing date | 2018-03-01 |
| Publishing country | Italy |
| Document type | Case Reports |
| ZDB-ID | 2674750-9 |
| ISSN | 2035-3006 |
| ISSN | 2035-3006 |
| DOI | 10.4084/MJHID.2018.018 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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