Article ; Online: Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2.
Biochemical and biophysical research communications
2020 Volume 538, Page(s) 116–124
Abstract: ... Among those, the ORF8 gene encodes for the homonymous multifunctional, highly immunogenic, immunoglobulin-like protein ... ORF8 protein in perspective to its potential as antiviral target and with special emphasis ... The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains nine open reading ...
| Abstract | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains nine open reading frames (ORFs) that encode for accessory proteins which, although dispensable for viral replication, are important for the modulation of the host infected cell metabolism and innate immunity evasion. Among those, the ORF8 gene encodes for the homonymous multifunctional, highly immunogenic, immunoglobulin-like protein that was recently found to inhibit presentation of viral antigens by class I major histocompatibility complex, suppress the type I interferon antiviral response and interact with host factors involved in pulmonary inflammation and fibrogenesis. Moreover, the ORF8 is a hypervariable gene rapidly evolving among SARS-related coronaviruses, with a tendency to recombine and undergo deletions that are deemed to facilitate the virus adaptation to the human host. Intriguingly, SARS-CoV-2 variants isolated in the beginning of the coronavirus disease 2019 (Covid-19) pandemic that were deleted of the ORF8 gene have been associated to milder symptoms and better disease outcome. This minireview summarizes the current knowledge on the SARS-CoV-2 ORF8 protein in perspective to its potential as antiviral target and with special emphasis on the biochemical, biophysical and structural aspects of its molecular biology. |
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| MeSH term(s) | Antiviral Agents/pharmacology ; Host-Pathogen Interactions/physiology ; Humans ; Immunity, Innate ; Mutation ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Viral Proteins/metabolism |
| Chemical Substances | Antiviral Agents ; ORF8 protein, SARS-CoV-2 ; Viral Proteins |
| Language | English |
| Publishing date | 2020-10-21 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 205723-2 |
| ISSN | 1090-2104 ; 0006-291X ; 0006-291X |
| ISSN (online) | 1090-2104 ; 0006-291X |
| ISSN | 0006-291X |
| DOI | 10.1016/j.bbrc.2020.10.045 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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