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  1. Article: Pipeline of Known Chemical Classes of Antibiotics.

    de Souza Mendes, Cristina d'Urso / de Souza Antunes, Adelaide Maria

    Antibiotics (Basel, Switzerland)

    2013  Volume 2, Issue 4, Page(s) 500–534

    Abstract: ... the chemical modification of antibiotics in known classes is still widely used to discover new antibiotics ... antibiotics in the pipeline belong to the following chemical classes: quinolones, aminoglycosides, macrolides ... in known classes of antibiotics, from discovery to clinical trial, in order to map out the technological ...

    Abstract Many approaches are used to discover new antibiotic compounds, one of the most widespread being the chemical modification of known antibiotics. This type of discovery has been so important in the development of new antibiotics that most antibiotics used today belong to the same chemical classes as antibiotics discovered in the 1950s and 1960s. Even though the discovery of new classes of antibiotics is urgently needed, the chemical modification of antibiotics in known classes is still widely used to discover new antibiotics, resulting in a great number of compounds in the discovery and clinical pipeline that belong to existing classes. In this scenario, the present article presents an overview of the R&D pipeline of new antibiotics in known classes of antibiotics, from discovery to clinical trial, in order to map out the technological trends in this type of antibiotic R&D, aiming to identify the chemical classes attracting most interest, their spectrum of activity, and the new subclasses under development. The result of the study shows that the new antibiotics in the pipeline belong to the following chemical classes: quinolones, aminoglycosides, macrolides, oxazolidinones, tetracyclines, pleuromutilins, beta-lactams, lipoglycopeptides, polymyxins and cyclic lipopeptides.
    Language English
    Publishing date 2013-12-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics2040500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pipeline of Known Chemical Classes of Antibiotics

    Cristina d'Urso de Souza Mendes / Adelaide Maria de Souza Antunes

    Antibiotics, Vol 2, Iss 4, Pp 500-

    2013  Volume 534

    Abstract: ... the chemical modification of antibiotics in known classes is still widely used to discover new antibiotics ... antibiotics in the pipeline belong to the following chemical classes: quinolones, aminoglycosides, macrolides ... in known classes of antibiotics, from discovery to clinical trial, in order to map out the technological ...

    Abstract Many approaches are used to discover new antibiotic compounds, one of the most widespread being the chemical modification of known antibiotics. This type of discovery has been so important in the development of new antibiotics that most antibiotics used today belong to the same chemical classes as antibiotics discovered in the 1950s and 1960s. Even though the discovery of new classes of antibiotics is urgently needed, the chemical modification of antibiotics in known classes is still widely used to discover new antibiotics, resulting in a great number of compounds in the discovery and clinical pipeline that belong to existing classes. In this scenario, the present article presents an overview of the R&D pipeline of new antibiotics in known classes of antibiotics, from discovery to clinical trial, in order to map out the technological trends in this type of antibiotic R&D, aiming to identify the chemical classes attracting most interest, their spectrum of activity, and the new subclasses under development. The result of the study shows that the new antibiotics in the pipeline belong to the following chemical classes: quinolones, aminoglycosides, macrolides, oxazolidinones, tetracyclines, pleuromutilins, beta-lactams, lipoglycopeptides, polymyxins and cyclic lipopeptides.
    Keywords antibacterial ; antibiotic ; clinical trials ; R& ; D ; Therapeutics. Pharmacology ; RM1-950 ; Medicine ; R ; DOAJ:Therapeutics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 540
    Language English
    Publishing date 2013-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Multidrug-resistant gram-negative organisms: a review of recently approved antibiotics and novel pipeline agents.

    Provenzani, A / Hospodar, A R / Meyer, A L / Leonardi Vinci, D / Hwang, E Y / Butrus, C M / Polidori, P

    International journal of clinical pharmacy

    2020  Volume 42, Issue 4, Page(s) 1016–1025

    Abstract: ... classes or to antibiotic classes already known but with new chemical structure were defined as "novel ... negative infections in the pipeline. Providers must be vigilant with the use of current antibiotics ... by the Food and Drug Administration (FDA) mostly belong to existing classes of antibiotics and have specific indications, limiting ...

    Abstract Background The discovery of antibiotics several decades ago was a defining moment in history. They were used to treat previously incurable diseases and save many lives. However, the use of antibiotics is not benign. Antibiotic resistance occurs due to the natural evolution of bacteria and gene transfer between bacteria via vertical and horizontal routes, resulting in protective mechanisms that render antibacterial agents ineffective. Aim of the review To list and describe current, novel pipeline antibiotics indicated for multidrug-resistant gram-negative bacteria. This review discusses the limited number of novel pipeline drugs available to combat the rapidly increasing number of multidrug-resistant bacteria and the need for initiatives to research and discover more novel antibiotics. Method A search of MEDLINE/PubMed using the search terms antibacterial pipeline OR antibiotic pipeline including publications between 1 January 2018 through 23 January 2020 resulted in 230 items. The results obtained were narrowed by adding the search term AND multi-drug resistant which resulted in 12 items. Then, ClinicalTrials.gov was searched for phase 2-3 "interventional" trials registered between 1 January 2018 and 23 January 2020 with the status "recruiting" or "completed" function and including World Health Organization-defined priority pathogens in the "condition or disease" field. The search process was then completed by introducing the term antibacterial agents in the "other terms" field. The trials search and selection resulted in 13 items. Relevant English-language studies and those conducted in humans were considered. Those drugs belonging to new antibiotic classes or to antibiotic classes already known but with new chemical structure were defined as "novel antibiotics". Results The studies selected and reviewed were those referring to a novel antibiotics. Thus, from MEDLINE/PubMed, we found only 1 item referred to a novel chemical class (Murepavadin n = 1). From ClinicalTrials.gov a total of 4 citations were identified (Ftortiazinon n = 1, Zoliflodacin n = 1, Gepotidacin n = 1, ETX2514 + sulbactam n = 1). Conclusion The antibiotics annually approved by the Food and Drug Administration (FDA) mostly belong to existing classes of antibiotics and have specific indications, limiting their use in many multidrug-resistant infections. There are limited novel drug classes targeting gram-negative infections in the pipeline. Providers must be vigilant with the use of current antibiotics, especially until research and development (R&D) advancements are made.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Drug Approval ; Drug Development ; Drug Discovery ; Drug Resistance, Multiple, Bacterial ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/isolation & purification ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-07-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2601204-2
    ISSN 2210-7711 ; 2210-7703 ; 0928-1231
    ISSN (online) 2210-7711
    ISSN 2210-7703 ; 0928-1231
    DOI 10.1007/s11096-020-01089-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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